Conserved Protein Domain Family
7tmA_CCR1

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cd15183: 7tmA_CCR1 
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.
Statistics
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PSSM-Id: 320311
View PSSM: cd15183
Aligned: 3 rows
Threshold Bit Score: 461.648
Threshold Setting Gi: 341940323
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative chemokine binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of chemokine receptors with bound ligands (chemokines, peptides, or chemical antagonists/agonists)
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #                                                #  #                #  ##
P32246     35 QLLPPLYSLVFVIGLVGNILVVLVLVQYKRlknmTSIYLLNLAISDLLFLFTLPFWIDYKlkdDWVFGdaMCKILSGFYY 114 human
P51675     35 GLLPPLYSLVFIIGVVGNVLVILVLMQHRRlqsmTSIYLFNLAVSDLVFLFTLPFWIDYKlkdDWIFGdaMCKLLSGFYY 114 house mouse
P51676     36 TVLTPLYSLVFIIGVIGHVLVVLVLIQHKRlrnmTSIYLFNLAISDLVFLSTLPFWVDYImkgDWIFGnaMCKFVSGFYY 115 house mouse
Feature 1                                                                         ######      
P32246    115 TGLYSEIFFIILLTIDRYLAIVHavfALRARtvTFGVITSIIIWALAILASMPGLYFsktqweFTHHTCSLHFPheslre 194 human
P51675    115 LGLYSEIFFIILLTIDRYLAIVHavfALRARtvTFGIITSIITWALAILASMPALYFfkaqweFTHRTCSPHFPykslkq 194 house mouse
P51676    116 LGLYSDMFFITLLTIDRYLAVVHvvfALRARtvTFGIISSIITWVLAALVSIPCLYVfksqmeFTYHTCRAILPrkslir 195 house mouse
Feature 1      #  ##                                                      #      #  #         
P32246    195 wKLFQALKLNLFGLVLPLLVMIICYTGIIKILlrrpnEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDflftheCE 274 human
P51675    195 wKRFQALKLNLLGLILPLLVMIICYAGIIRILlrrpsEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDvlftnqCE 274 house mouse
P51676    196 fLRFQALTMNILGLILPLLAMIICYTRIINVLhrrpnKKKAKVMRLIFVITLLFFLLLAPYYLAAFVSAFEDvlftpsCL 275 house mouse
Feature 1      #   #  ##  #                         
P32246    275 QSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGeRFRKYL 312 human
P51675    275 QSKQLDLAMQVTEVIAYTHCCVNPIIYVFVGeRFWKYL 312 house mouse
P51676    276 RSQQVDLSLMITEALAYTHCCVNPVIYVFVGkRFRKYL 313 house mouse

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