Conserved Protein Domain Family
7tmA_Bradykinin_R

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cd15189: 7tmA_Bradykinin_R 
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.
Statistics
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PSSM-Id: 320317
View PSSM: cd15189
Aligned: 4 rows
Threshold Bit Score: 397.223
Threshold Setting Gi: 85681914
Created: 11-Dec-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some angiotensin receptor family (class A) members with bound ligands (agonist peptides or chemical compound agonists/antagonists)
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligands, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #                                                 #  ##   #            #  
P46663     38 RVLPTFIISICFFGLLGNLFVLLVFLLPRRqlnVAEIYLANLAASDLVFVLG-LPFWAENIwnqFNWPFGallCRVINGV 116 human
AAN77031   37 SIIPPYIFIVCLMGILGNSFVLLVFLLQRGrwsVPEIYLGNLALADLIFTSLcLPFWAMNIlnyFMWLYGefmCKVVNMS 116 zebrafish
P30411     58 TIQPPFLWVLFVLATLENIFVLSVFCLHKSsctVAEIYLGNLAAADLILACG-LPFWAITIsnnFDWLFGetlCRVVNAI 136 human
CAG10408    4 AIIPPYIFTLCLFGLLFNGFVLLVYLIHKDrltVAEIYLGNLALADFVLLSG-LPFWAMNIlneFNWPYGdalCKLVNSA 82  spotted green puff...
Feature 1     ##  #                                                  #   #                #   
P46663    117 IKANLFISIFLVVAISQDRYRVLVhpMASRRQQrrRQARVTCVLIWVVGGLLSIPTFLLRsiqavp--dlnitACILLLP 194 human
AAN77031  117 IMVNMYTSIYMLVMVNVDRYLALVltMRARWLRrkRYAKLICVILWLFGLGMGAPTAAMRklidip--ahqsvECMLNYP 194 zebrafish
P30411    137 ISMNLYSSICFLMLVSIDRYLALVktMSMGRMRgvRWAKLYSLVIWGCTLLLSSPMLVFRtmkeysdeghnvtACVISYP 216 human
CAG10408   83 IVVNFYTSSYTLVMISADRYLALVktMEAAWLRrtLYAKLICLLLWMWGLLLSTPTMLHRkvkfie--elgttACVMDYS 160 spotted green puff...
Feature 1                                                                          #  #       
P46663    195 he-aWHFARIVELNILGFLLPLAAIVFFNYHILASLRtreevsrtrcggRKDSKTTALILTLVVAFLVCWAPYHFFAFLE 273 human
AAN77031  195 nr-nWRIAHLLQLNIVGFALPFLVITFCCFNIVQALKrrrds--gywedGNDRKATILVCAVTFLFFFCWGPFHFLTFLD 271 zebrafish
P30411    217 sl-iWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRnnemq--kfkeiQTERRATVLVLVVLLLFIICWLPFQISTFLD 293 human
CAG10408  161 hgssWKLTHQVLMNVMGFLVPFLIILFSSLNILKALSerkes--sgfrdINDSKATALVYAVTLLFLLCWGPYQVVIFLD 238 spotted green puff...
Feature 1                             #   #                     
P46663    274 FLfqvqavrgcfwedFIDLGLQLANFFAFTNSSLNPVIYVFVGrlFRTKV 323 human
AAN77031  272 LLcdlkvldekewahFLNIGNQFSVYLAFSNSCLNPVLYVCSGnyFRRKV 321 zebrafish
P30411    294 TLhrlgilsscqderIIDVITQIASFMAYSNSCLNPLVYVIVGkrFRKKS 343 human
CAG10408  239 ILndvgvldearwyhALNIAAQVSVYLAFLNSALNPLLYAFSGqyFRRKV 288 spotted green pufferfish

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