2KS9


Conserved Protein Domain Family
7tmA_TACR-like

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cd15202: 7tmA_TACR-like 
Click on image for an interactive view with Cn3D
tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.
Statistics
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PSSM-Id: 320330
View PSSM: cd15202
Aligned: 4 rows
Threshold Bit Score: 383.009
Threshold Setting Gi: 310942510
Created: 24-Jul-2013
Updated: 26-Jul-2017
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 41 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                             #  ##            ###### 
2KS9_A     33 VLWAAAYTVIVVTSVVGNVVVMWIILAHKRmrtvTNYFLVNLAFAEASMAAFNTVVNFTYAvh-neWYYGlfyCKFHNFF 111 human
AAF72891   56 VLLSIFYGIISLVAVAGNFMVMWIVATSRRmqtvTNFFIANLAVADIIIGLFSIPFQFQAAll-qrWVLPefmCAFCPFV 134 southern cattle tick
Q9NYM4     72 ALLIVAYSFIIVFSLFGNVLVCHVIFKNQRmhsaTSLFIVNLAVADIMITLLNTPFTLVRFvn-stWIFGkgmCHVSRFA 150 human
P25931    106 IIVYMLYIPIFIFALIGNGTVCYIVYSTPRmrtvTNYFIASLAIGDILMSFFCVPSSFISLfilnyWPFGlalCHFVNYS 185 fruit fly
Feature 1     ##  #                                          # #####                          
2KS9_A    112 PIAAVFASIYSMTAVAFDRYMAIIHPlqpRLSATATKVVICVIWVLALLLAFPQGYYsttetm-------psrvvCMIEW 184 human
AAF72891  135 QVLSVNVSIFTLTAIALDRYRAVMSPlkaRTTKLRAKFIICGIWTLAVAAALPCALAlrvetqveshalnltkpfCHEVG 214 southern cattle tick
Q9NYM4    151 QYCSLHVSALTLTAIAVDRHQVIMHPlkpRISITKGVIYIAVIWTMATFFSLPHAICqklftfky--sedivrslCLPDF 228 human
P25931    186 QAVSVLVSAYTLVAISIDRYIAIMWPlkpRITKRYATFIIAGVWFIALATALPIPIVsgldipmspwhtkcekyiCREMW 265 fruit fly
Feature 1             #  ### ### ##                                                        #  
2KS9_A    185 PehpnkiyEKVYHICVTVLIYFLPLLVIGYAYTVVGITLwaseipgds-sdryheqvSAKRKVVKMMIVVVCTFAICWLP 263 human
AAF72891  215 Isr---kaWRIYNHVLVCLQYFFPLLTICFVYARMGLKLkeskspgnaqgardagilKNKKKVIKMLFVIVALFAFCWLP 291 southern cattle tick
Q9NYM4    229 Pepa-dlfWKYLDLATFILLYILPLLIISVAYARVAKKLwlcnmigdvtteqyfalrRKKKKTIKMLMLVVVLFALCWFP 307 human
P25931    266 Psr---tqEYYYTLSLFALQFVVPLGVLIFTYARITIRVwakrppgeaetnrdqrmaRSKRKMVKMMLTVVIVFTCCWLP 342 fruit fly
Feature 1     ## ##  #           ## ###  #  ##                     
2KS9_A    264 FHIFFLLPyinpdlylkkfIQQVYLAIMWLAMSSTMYNPIIYCCLNdrFRLGF 316 human
AAF72891  292 YQLYNILRevfpkidkykyINIIWFCTHWLAMSNSCYNPFIYAIYNerFKREF 344 southern cattle tick
Q9NYM4    308 LNCYVLLLsskv----irtNNALYFAFHWFAMSSTCYNPFIYCWLNenFRIEL 356 human
P25931    343 FNILQLLLndeef-ahwdpLPYVWFAFHWLAMSHCCYNPIIYCYMNarFRSGF 394 fruit fly

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