Conserved Protein Domain Family
7tmF_FZD1_insect

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cd15248: 7tmF_FZD1_insect 
class F insect frizzled subfamily 1, member of 7-transmembrane G protein-coupled receptors
This group includes subfamily 1 of the frizzled (FZD) family of seven transmembrane-spanning proteins, which constitute a novel and separate class of G-protein coupled receptors, found in insects such as Drosophila melanogaster. This class F protein family consists of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. The WNT pathway plays a critical role in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.
Statistics
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PSSM-Id: 320376
Aligned: 4 rows
Threshold Bit Score: 606.041
Created: 22-Jan-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to Human smoothened receptor bound to an antitumor agent.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      #        #                                                 #                   
EHJ67969    1 MFFSEDEKNFARLWIGTWATLCTVSCLFTVLTFLIDTDRFRYPERPIIFLSVCYLMVAAAYVMGWSSGDTVSCQGPFplt 80  monarch butterfly
P18537    236 MFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFppp 315 fruit fly
EFX86267  288 MFFNESEVRFSRVWIVVWGAICMASCLFTVLTFLLDVRRFRYPERPVVFLSVCYFMVALAYVIGYAMGDSVSCNAPFdpp 367 common water flea
EEC05379  228 MFFRGENLKFSRYWIGAWAVQCMVSTLFTVLTFLIDMQRFRYPERPIIFLSFCNLMVSATYFAGFVLGDQVACNEPFdpp 307 black-legged tick
Feature 1              #                                                                      
EHJ67969   81 vs--gtrlpNTSVITQGT-KHEPCTILFMVVYFFSMASSIWWVILTLTWFLAAGLKWGhEAIEANSQYFHLAAWAVPAIK 157 monarch butterfly
P18537    316 vk--lgrlqMMSTITQGHrQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGhEAIENKSHLFHLVAWAVPALQ 393 fruit fly
EFX86267  368 qdfsvdkadMVETITQGT-KRESCTILFMLLYYFEMAANLWWVVLTLTWFLAAGLKWGhEPIEAKSHYFHLVTWALPAAL 446 common water flea
EEC05379  308 gg--hanmeMVRTITQNN-KKETCTVMFMVLYFFSMAGSIWWVVLTLTWFLAAGLKWGhEAIESNSQYFHLAAWTIPAVK 384 black-legged tick
Feature 1                 #    # #  ##    #                                                   
EHJ67969  158 TISILAMGKVDGDVLSGVCYVGLWDSEALRGFVLAPLCVYLVLGTIFLFAGFVSLFRIRTVMKhDGTKTDKLEKLMIRIG 237 monarch butterfly
P18537    394 TISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKtDGKRTDKLERLMLRIG 473 fruit fly
EFX86267  447 TIAILAMGKVEGDVLSGVCSVGIWDMSALRLFVLAPLFLFLIVGTIFLLGGFISLFRVRTLMKsGGTKTDKLEKFMLRIG 526 common water flea
EEC05379  385 TITILAMGKVEGDVLSGVCYVGLWNMDALRGFVLAPLFVYLALGKVFLMAGFISLCHIRTVMKhDGTKTDKLEKLMVRIG 464 black-legged tick
Feature 1                            #  ##                                          #    #  ##
EHJ67969  238 IFGVLYTVPALIVIACLFYEQVHFDsWMLTWHRDmcskpvysi----------------pcpftphevDRPKFEMFMIKY 301 monarch butterfly
P18537    474 FFSGLFILPAVGLLGCLFYEYYNFDeWMIQWHRDickpfsipcp---------------aarapgspeARPIFQIFMVKY 538 fruit fly
EFX86267  527 IYSFLYTVPAIIVIACLLHEQAFFDsWMLRWQEDkcrdpqwikfvfacpsqslayakgaggyptaptyPKPEFAVFMIKY 606 common water flea
EEC05379  465 IFSFLYTLPALTVLCCYFYEQAHFDdWMLGWHWQvnaekrwsipcp-----------epsclrrdralRRPEFYVFMIKY 533 black-legged tick
Feature 1                                   
EHJ67969  302 LMTMIVGITSSFWIWSGKTLVSWRQFFDKI 331 monarch butterfly
P18537    539 LCSMLVGVTSSVWLYSSKTMVSWRNFVERL 568 fruit fly
EFX86267  607 LMMLIVGISSGFWVMSSKTLATWSNFYRRL 636 common water flea
EEC05379  534 LGILIVGITSGVWIWSGKTFASWRNFYARL 563 black-legged tick

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