Conserved Protein Domain Family
7tmF_FZD8

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cd15250: 7tmF_FZD8 
class F frizzled subfamily 8, member of 7-transmembrane G protein-coupled receptors
This group includes subfamily 8 of the frizzled (FZD) family of seven transmembrane-spanning proteins, which constitute a novel and separate class of GPCRs, and its closely related proteins. This class F protein family consists of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. The WNT pathway plays a critical role in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.
Statistics
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PSSM-Id: 320378
Aligned: 5 rows
Threshold Bit Score: 593.829
Created: 22-Jan-2014
Updated: 17-Oct-2022
Structure
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Aligned Rows:
  next features
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ##########################                                             
AAD05435     228 PYFTQDERTFTAFWIGLWSVLCFISTFATVATFLIDMERFKYPERPIIFLSACYMFVSIGYIVRLIAgHEKVACNre--- 304 zebrafish
O93274       226 PFFSPEERTFTEFWIGLWSVLCFASTFATVSTFLIDMERFKYPERPIIFLSACYLLVSTGYLIRLIAgHEKVACSrge-- 303 African clawed ...
AAC83940     221 PYLSQEERTFATFWIGIWSVLCFLSTFATVATFLIDIERFKYPERPIIFLSACYMFVSLGYIIRLIAgHERVACNqn--- 297 zebrafish
EAW85909     267 PFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAgHEKVACSggapg 346 human
XP_008110531 245 PTSPQXERAFTAFWIGLWTIICFLSTFATVSTFLIDMERFKYPERPIVFLAACYLFVSLGYLVRLVAgHEKVACSggaaa 324 green anole
Feature 1                                                                                        
AAD05435     305 ----------------------------------ydVEHIHYETtGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAAG 350 zebrafish
O93274       304 ---------------------------------ldlEHIIHYETtGPALCTLVFLLIYFFGMASSIWWVILSLTWFLAAG 350 African clawed ...
AAC83940     298 ----------------------------------heVDHIHYETtGPALCTLVFLLIYFFGMASAIWWVILSFTWFLAAG 343 zebrafish
EAW85909     347 aggaggaggaaagagaagagaggpggrgeyeelgavEQHVRYETtGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAG 426 human
XP_008110531 325 agpsgasgasagaaavavggrgaaggaaelqpelagAEHVRYEStGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAG 404 green anole
Feature 1                                                                                        
AAD05435     351 MKWGnEAIAGYSQYFHLAAWLIPSMKSIAVLALSSVDGDPVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAGFVS 430 zebrafish
O93274       351 MKWGnEAIAGYSQYFHLAAWLVPSIKSIAVLALSSVDGDPVAGICFVGNQNLDNLRGFVLAPLVIYLFIGSMFLLAGFVS 430 African clawed ...
AAC83940     344 LKWGnEAIARYSQYFHMAAWLIPSVKSITVLALSSVDGDSIAGICYVGNQNLDNLRGFVLAPLVIYLFIGTIFLFAGFVS 423 zebrafish
EAW85909     427 MKWGnEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVS 506 human
XP_008110531 405 MKWGnEAIASYAQYFHLAAWLLPSVKSIAVLALSSVDGDPVAGICYVGNQSLENLRGFVLAPLLIYLAIGSMFLLAGFVS 484 green anole
Feature 1                                                                                        
AAD05435     431 LFRIRSVIKQg--gTKTDKLEKLMIRIGIFTVLYTVPATIIVACYFYEQHNRQsWEITHNCSclle---qeiKRPDYAVF 505 zebrafish
O93274       431 LFRIRSVIKQg--gTKTDKLEKLMIRIGIFSVLYTVPATIVVACFFYEQHNRQgWEVAHNCNscqpe-maqpHRPDYAVF 507 African clawed ...
AAC83940     424 MFRIRSVIKQg--gTKTDKLERLMVRIGVFTVLYTVVAIMIVACYVYEHHNREaWEIAHACNcssd---kkaPKPDYAVF 498 zebrafish
EAW85909     507 LFRIRSVIKQqdgpTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPrWEATHNCPclrdlqpdqaRRPDYAVF 586 human
XP_008110531 485 LFRIRSVIKQqggpTKTHKLEKLMIRLGLFTVLYTVPAASVVACLFYEQHNRPrWEATHNCPclrdqqpdqaRRPDYAVF 564 green anole
Feature 1                                        
AAD05435     506 MLKYFMCLLVGITSGVWTWSGKTLESWRSFCT 537 zebrafish
O93274       508 MLKYFMCLVVGITSGVWIWSGKTLESWRAFCT 539 African clawed frog
AAC83940     499 MLKYLMCLLIGITSGAWTWSSKTLDSWRALCT 530 zebrafish
EAW85909     587 MLKYFMCLVVGITSGVWVWSGKTLESWRSLCT 618 human
XP_008110531 565 MLKYFMCLVVGITSGVWVWSGKTLESWKALCT 596 green anole

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