4IAR,4IAQ


Conserved Protein Domain Family
7tmA_5-HT1B_1D

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cd15333: 7tmA_5-HT1B_1D 
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serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors
The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.
Statistics
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PSSM-Id: 320455
Aligned: 10 rows
Threshold Bit Score: 432.297
Threshold Setting Gi: 2494925
Created: 13-Nov-2008
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:4IAQ: Human 5-HT1B G protein-coupled receptor binds the agonist antimigraine medication dihydroergotamine, contacts at 4A.
    View structure with Cn3D
  • Structure:4IAR: Human 5-HT1B binds ergotamine, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       #
4IAR_A        17 LPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTgRWTLGQVVCDFW 96 
XP_005017926  19 LSGKIVLAVVLALVTLATVLSNAFVIATVYQTRKLHTPANYLIASLAVTDLLVSILVMPISTVYTVTgKWTLGQIVCDIW 98  mallard
P28222        46 LPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTgRWTLGQVVCDFW 125 human
4IAQ_A        17 LPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTgRWTLGQVVCDFW 96 
XP_002936251  42 SFSKIILTVILALITLATLLSNAFVITTVYQTRKLHTPANYLIASLAFTDLLVSILVLPIAIVYTVTgKWTLGQIICDMW 121 western clawed ...
XP_003971468  36 VAVQAGVAVTLALITFATTLSNAFVIATIYQSRKLHTPANFLIASLAVTDLLVSILVMPISALYTVSqTWTLGQVMCDIW 115 torafugu
P28221        35 QALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTIThTWNFGQILCDIW 114 human
XP_003642607  35 LGLKISLSVLLSVITLATILANVFVVITIFLTRKLHTPANYLIGSLAVTDLLVSVLVMPISIAYTVThTWAFGQVLCDIW 114 chicken
XP_002938881  10 LGLKITLAVLLSIITLATLLSNVFVIITIVMTRKLHTPANYLIGSLAFTDLLVSILVMPISIAYTVThTWTFGQIVCDIW 89  western clawed ...
P79748        33 LGLQISVSVVLAIVTLATMLSNAFVIATIFLTRKLHTPANFLIGSLAVTDMLVSILVMPISIVYTVSkTWSLGQIVCDIW 112 torafugu
Feature 1        #  ##  ##                                                                #      
4IAR_A        97 LSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEevsECVVNTDH 176
XP_005017926  99 LSSDITCCTASILHLCVIALDRYWAITDAVEYSTKRTPKRAAGMIALVWVFSICISMPPLFWRQAKAEEv-sHCVVNTDH 177 mallard
P28222       126 LSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEevsECVVNTDH 205 human
4IAQ_A        97 LSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEevsECVVNTDH 176
XP_002936251 122 LSSDITCCTASILHLCVIALDRYWAITDAVEYTKKRTPKRAVVMIALVWVFSISISMPPLFWRQSKAEEi-aVCAVNTDH 200 western clawed ...
XP_003971468 116 LSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPARAAGMIATAWVIAISISLPPFFWRQVKAEEv-tSCNVNSDH 194 torafugu
P28221       115 LSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEemsDCLVNTSQ 194 human
XP_003642607 115 LSSDITCCTASILHLCVIALDRYWAITDALEYAKRRTAGRAMLMIAVVWMISISISVPPFFWRQVKAHEeiaKCNVNTDQ 194 chicken
XP_002938881  90 LLSDITCCTASILHLCVIALDRYWAITDALEYTKHRTARRAAVMILVVWIISICISIPPLFWRQAKAHEeltVCTINTDQ 169 western clawed ...
P79748       113 LSSDITFCTASILHLCVIALDRYWAITDALEYSKRRTMRRAAVMVAVVWVISISISMPPLFWRQAKAHEelkECMVNTDQ 192 torafugu
Feature 1              #   #                                                                     
4IAR_A       177 ILYTVYSTVGAFYFPTLLLIALYGRIYVEARsriadlednwetlndnlkviekadnaaqvkdaltkmraaaldaqkatpp 256
XP_005017926 178 VLYTVYSTVGAFYFPTLLLIALYGRIYVEARsrilkqtpkkagkrltraqlitdspgssssvtsin-------------- 243 mallard
P28222       206 ILYTVYSTVGAFYFPTLLLIALYGRIYVEARsrilkqtpnrtgkrltraqlitdspgstssvtsin-------------- 271 human
4IAQ_A       177 ILYTVYSTVGAFYFPTLLLIALYGRIYVEARsriadlednwetlndnlkviekadnaaqvkdaltkmraaaldaqkatpp 256
XP_002936251 201 ILYTVYSTVGAFYIPTLLLIALYGRIYVEARsrilkqspkttgkrltkahlitdspgsssvsstns-------------- 266 western clawed ...
XP_003971468 195 IFYTIYSTFGAFYIPTLLLIALYGRIYVEARkrilkqshnkpgkrltsahlitnspgsvasttslny------------- 261 torafugu
P28221       195 ISYTIYSTCGAFYIPSVLLIILYGRIYRAARnrilnppslygkrfttahlitgsagsslcslnss--------------- 259 human
XP_003642607 195 ISYTIYSTCGAFYIPTVLLLILYGRIYVAARsrilkppslygkrfttahlitgsagsslcsinas--------------- 259 chicken
XP_002938881 170 ISYTIYSTCGAFYIPTVLLILLYGKIYIAARsrilkppsiygkrfttaqlipgstgssfcsinan--------------- 234 western clawed ...
P79748       193 ISYTLYSTFGAFYVPTVLLIILYGRIYVAARsrifktpsysgkrfttaqliqtsagsslcslnsasnqe----------- 261 torafugu
Feature 1                                                                                        
4IAR_A       257 kledks--pdspemkdfrhgfdilvgqiddalklanegkvkeaqaaaeqlkttrnayiqkylaARERKATKTLGIILGAF 334
XP_005017926 244 ----------------------------skapegssetgspvymnqvkvkvsdallekkkltaARERKATKTLGIILGAF 295 mallard
P28222       272 ----------------------------srvpdvpsesgspvyvnqvkvrvsdallekkklmaARERKATKTLGIILGAF 323 human
4IAQ_A       257 kledkspdspemkdfrhgfdilvgqiddalklanegkvkeaqaaaeqlkttrnayiqkyllmaARERKATKTLGIILGAF 336
XP_002936251 267 -----------------------------rtlempsdagspvylnqvkvkvsdallekkkimaARERKATKTLGVILGAY 317 western clawed ...
XP_003971468 262 ----------------------------gtndssscdttsspnigqvkvtvsdallekkrisaARERKATKTLGIILGAY 313 torafugu
P28221       260 -----------------------------lheghshsagsplffnhvkikladsalerkrisaARERKATKILGIILGAF 310 human
XP_003642607 260 -----------------------------lheghshsggspifinhvqikladsilerkrisaARERKATKTLGIILGAF 310 chicken
XP_002938881 235 -----------------------------vhmehphtsetpvcinhikikladsiierkrlsaAREKKATKTLGIILGAF 285 western clawed ...
P79748       262 --------------------------ahlhsgaggegggsplfvnsvkvkladnvlerkrlcaARERKATKTLGIILGAF 315 torafugu
Feature 1           #  ##     #           #  ##  #   #                            
4IAR_A       335 IVCWLPFFIISLVMPICKD-ACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEd-------FKQAF 391
XP_005017926 296 IVCWLPFFIISLVLPICKD-ACWFHMAIFDFFTWLGYLNSLINPIIYTMSNEd-------FKQAF 352 mallard
P28222       324 IVCWLPFFIISLVMPICKD-ACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEd-------FKQAF 380 human
4IAQ_A       337 IVCWLPFFIISLVMPICKD-ACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEd-------FKQAF 393
XP_002936251 318 IVCWLPFFIISLVMPICKD-ACWFHPAIFDFFNWLGYLNSLINPIIYTMSNEd-------FKQAF 374 western clawed frog
XP_003971468 314 IVCWLPFFIYTLLVPVCPScFYPELFDSFTWLGYLNSLINPIIYTMSNEDFKqafhklirFKCCR 378 torafugu
P28221       311 IICWLPFFVVSLVLPICRD-SCWIHPALFDFFTWLGYLNSLINPIIYTVFNEe-------FRQAF 367 human
XP_003642607 311 IFCWLPFFVMSLVLPICQD-ACWFHPILLDFFTWLGYLNSLINPVIYTAFNEe-------FKQAF 367 chicken
XP_002938881 286 IVCWLPFFVVSLVLPICRD-ACWFDPLLFDFFTWLGYLNSLINPVIYTVFNEd-------FKKAF 342 western clawed frog
P79748       316 IICWLPFFVVTLVWAICKE-CSFDPLLFDVFTWLGYLNSLINPVIYTVFNDE--------FKQAF 371 torafugu

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