Conserved Protein Domain Family
7tmB1_Secretin_R-like

?
cd15930: 7tmB1_Secretin_R-like 
secretin receptor-like group of hormone receptors, member of the class B family of seven-transmembrane G protein-coupled receptors
This group represents G protein-coupled receptors for structurally similar peptide hormones that include secretin, growth-hormone-releasing hormone (GHRH), pituitary adenylate cyclase activating polypeptide (PACAP), and vasoactive intestinal peptide (VIP). These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. Secretin, a polypeptide secreted by entero-endocrine S cells in the small intestine, is involved in maintaining body fluid balance. This polypeptide regulates the secretion of bile and bicarbonate into the duodenum from the pancreatic and biliary ducts, as well as regulates the duodenal pH by the control of gastric acid secretion. Studies with secretin receptor-null mice indicate that secretin plays a role in regulating renal water reabsorption. Secretin mediates its biological actions by elevating intracellular cAMP via G protein-coupled secretin receptors, which are expressed in the brain, pancreas, stomach, kidney, and liver. GHRHR is a specific receptor for the growth hormone-releasing hormone (GHRH) that controls the synthesis and release of growth hormone (GH) from the anterior pituitary somatotrophs. Mutations in the gene encoding GHRHR have been connected to isolated growth hormone deficiency (IGHD), a short-stature condition caused by deficient production of GH or lack of GH action. VIP and PACAP exert their effects through three G protein-coupled receptors, PACAP-R1, VIP-R1 (vasoactive intestinal receptor type 1, also known as VPAC1) and VIP-R2 (or VPAC2). PACAP-R1 binds only PACAP with high affinity, whereas VIP-R1 and -R2 specifically bind and respond to both VIP and PACAP. VIP and PACAP and their receptors are widely expressed in the brain and periphery. They are upregulated in neurons and immune cells in responses to CNS injury and/or inflammation and exert potent anti-inflammatory effects, as well as play important roles in the control of circadian rhythms and stress responses, among many others. All B1 subfamily GPCRs are able to increase intracellular cAMP levels by coupling to adenylate cyclase via a stimulatory Gs protein. However, depending on its cellular location, some members of subfamily B1 are also capable of coupling to additional G proteins such as G(i/o) and/or G(q) proteins, thereby leading to activation of phospholipase C and intracellular calcium influx.
Statistics
?
PSSM-Id: 320596
Aligned: 6 rows
Threshold Bit Score: 439.559
Created: 3-Jul-2014
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
  next features
Feature 1:putative polypeptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on mutagenesis of human glucagon receptor (GCGR), and modeling studies of GCGR and other related class B GPCRs
  • Comment:Residues in the globular N-terminal extracellular domain and the extracellular loops of the 7TM domain may also be involved in ligand binding.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1            #   #                                         #  ##  #                   
AAA87556  139 LLKLKVMYTVGYSSSLVMLLVALGILCAFRRlhctrNYIHMHLFVSFILRALSNFIKDAVLfssddvty---cdphragC 215 human
AFM84635  137 FHTVKILYTCGYAASLTALVTAISIFSLFRKlhcprNFIHVNLFVSFILRGIAVFIKDAVLfadedvdh---ctmstvgC 213 African clawed frog
Q91085    138 YGTVKTGYTIGHTLSLIALTAAMIILCLFRKlhctrNYIHMHLFMSFIMRAIAVFIKDVTLfesgepeh---cfvssvgC 214 turkey
AAZ30048  123 FSTIKIIYTVGYSLSITSLIIAVTVLMAFRRlrcprNYIHIQLFFTFILKAIAIFIKDSVLfqeedidh---csfstteC 199 chicken
P41587    123 YILVKAIYTLGYSVSLMSLATGSIILCLFRKlhctrNYIHLNLFLSFILRAISVLVKDDVLysssgtlhcpdqpsswvgC 202 human
P70205    150 YLSVKALYTVGYSTSLVTLTTAMVILCRFRKlhctrNFIHMNLFVSFMLRAISVFIKDWILyaeqdssh---cfvstveC 226 house mouse
Feature 1     #      #                                                                      ##
AAA87556  216 KLVMVLFQYCIMANYSWLLVEGLYLHTLLAisffserKYLQGFVAFGWGSPAIFVALWAIARhfledvgCWDinaNASIW 295 human
AFM84635  214 KAAVVFFQYSVLANFSWLLVEGMYLHTLLTltftyqrKYFWWYIVIGWGAPALTVSVWIKTRiqfdntgCWDd-yESIYW 292 African clawed frog
Q91085    215 KAMMVFFQYCVMANFFWLLVEGLYLHTLLVisffserKYFWWYILIGWGAPSVFITAWTVVRiyffnvgCWEeiiESPIW 294 turkey
AAZ30048  200 KISVVFCHYFMMTNFIWLLVEALYLNCLLLsslshgrRYFWWLVLFGWGFPTLFTFIWILAKfyfedtaCWDinqDSPYW 279 chicken
P41587    203 KLSLVFLQYCIMANFFWLLVEGLYLHTLLVaml-pprRCFLAYLLIGWGLPTVCIGAWTAARlyledtgCWDtndHSVPW 281 human
P70205    227 KAVMVFFHYCVVSNYFWLFIEGLYLFTLLVetffperRYFYWYTIIGWGTPTVCVTVWAVLRlyfddagCWDmndSTALW 306 house mouse
Feature 1      # #                                                                            
AAA87556  296 WIIRGPVILSILINFILFINILRILMRKLRtqetr----------------------------gnevsHYKRLARSTLLL 347 human
AFM84635  293 WIIKTPILLAIFINFIIFLNVIRILIQKIRcpdis----------------------------knykqQYMRLAKSTLLL 344 African clawed frog
Q91085    295 WIIKTPILVSILVNFILFICIIRILVQKLHspdvg----------------------------hnetsQYSRLAKSTLLL 346 turkey
AAZ30048  280 WLIKGPIIISVGVNFVLFINIIRILLKKLDprqin----------------------------fnnssQYRRLSRSTLLL 331 chicken
P41587    282 WVIRIPILISIIVNFVLFISIIRILLQKLTspdvg----------------------------gndqsQYKRLAKSTLLL 333 human
P70205    307 WVIKGPVVGSIMVNFVLFIGIIIILVQKLQspdmggnessiyfscvqkcyckpqraqqhsckmselstITLRLARSTLLL 386 house mouse
Feature 1            #  #            #   #                               
AAA87556  348 IPLFGIHYIVFAFSPEd-aMEIQLFFELALGSFQGLVVAVLYCFLNgEVQLEVQKKWQQ 405 human
AFM84635  345 IPLFGVHYVIFALFPEhigIWARMYFELVLGSNQGFIVALLYCFLNgEVQAEIQRHWGK 403 African clawed frog
Q91085    347 IPLFGIHYIMFAFFPDnfkAQVKLVFELVVGSFQGFVVAVLYCFLNgEVQAELKRKWRR 405 turkey
AAZ30048  332 IPLFGTHYIVFNFLPEytsLGIRLYLELCIGSFQGFIVALLYCFLNqEVQTEIGRRWHG 390 chicken
P41587    334 IPLFGVHYMVFAVFPIsisSKYQILFELCLGSFQGLVVAVLYCFLNsEVQCELKRKWRS 392 human
P70205    387 IPLFGIHYTVFAFSPEnvsKRERLVFELGLGSFQGFVVAVLYCFLNgEVQAEIKRKWRS 445 house mouse

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap