Conserved Protein Domain Family

cl17068: AFD_class_I Superfamily (this model, PSSM-Id:327384 is obsolete and has been replaced by 418409)
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Adenylate forming domain, Class I superfamily
This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Accession: cl17068
PSSM Id: 327384
Name: AFD_class_I
Created: 13-Sep-2012
Updated: 5-Dec-2016
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