?cl27511: Na_Ca_ex Superfamily (this model, PSSM-Id:332332 is obsolete)
Sodium/calcium exchanger protein This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",