1HCN,1XWD


Conserved Protein Domain Family
Cys_knot

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pfam00007: Cys_knot (this model, PSSM-Id:333760 is obsolete and has been replaced by 394966)
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Cystine-knot domain
The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.
Statistics
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PSSM-Id: 333760
View PSSM: pfam00007
Aligned: 26 rows
Threshold Bit Score: 69.3589
Threshold Setting Gi: 116241320
Created: 13-Mar-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1HCN_B    6 RPRCRPIN---ATLAVEKEGCPVCITVNTTICAGYCPTMT--RVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVV 80   unidentified
Q08127   19 LSICSPVD---YTLYVEKPECDFCVAINTTICMGFCYSLDpnVVGPAVKRLVVQRGCTYQAVEYRTAELPGCPPHVDPRF 95   European eel
P37240   19 VPMCVPTD---YTLYEERRECDFCVAINTTICMGFCYSRDsnMKELAGPRFLIQRGCTYDQVEYRTVILPGCPLHANPLF 95   rainbow trout
P37205    5 SYGCHPKN---ISISVES--CGITEFILTTICEGQCYLED--PVYISHD---EQKICNG-DWSYEVKHIEGCPVG----V 69   bigeye tuna
P30971   17 CFGCHLKN---VSIPMER--CGQRVCIHTTICEGLCFSED--AVFESPDEAPEHRVCNG-DWSYEVKHIQGCPES----I 84   mummichog
Q02817 5072 RVPCSTVP---VTTEVSYAGCT--KTVLMNHCSGSCGTFV--MYSAKAQALDHSCSCCKEEKTSQREVVLSCPNGGSLTH 5144 human
P18406  281 GKKCSKTKkspEPVRFTYAGCSSVKKYRPKYC-GSCV---------DGR-------CCTPLQTRTVKMRFRCEDGEMFSK 343  house mouse
P19336  278 GKKCTKTKkspSPVRFTYAGCSSVKKYRPKYC-GSCV---------DGR-------CCTPQQTRTVKIRFRCDDGETFTK 340  chicken
P29279  253 GKKCIRTPkisKPIKFELSGCTSMKTYRAKFC-GVCT---------DGR-------CCTPHRTTTLPVEFKCPDGEVMKK 315  human
P10257   29 RYGCRLNN---MTIIVEREDCHG--SITITTCAGLCETTD--LNYQSTWLPRSQGVCNFKEWSYEKVYLEGCPSGVEP-F 100  chum salmon
1HCN_B   81 SYAVALSCQCA--LCRRSTTDCGGPKDHPLTC 110  unidentified
Q08127   96 SYPVALHCTCR--ACDPARDECTHRASADGDR 125  European eel
P37240   96 TYPVALSCHCG--TCNTDSDECAHKASSGDGA 125  rainbow trout
P37205   70 TYPVARNCECT--ACNTGNTYCGRLPGYVPSC 99   bigeye tuna
P30971   85 TYPVATNCYCS--ACNTKDTYCTRLYAHIPSC 114  mummichog
Q02817 5145 TYTHIESCQCQdtVCGLPTGTSRRARRSPRHL 5176 human
P18406  344 NVMMIQSCKCNy-NCPHPNEASFRLYSLFNDI 374  house mouse
P19336  341 SVMMIQSCRCNy-NCPHANEAYPFYRLVNDIH 371  chicken
P29279  316 NMMFIKTCACHy-NCPGDNDIFESLYYRKMYG 346  human
P10257  101 FIPVAKSCDCI--KCKTDNTDCDRISMATPSC 130  chum salmon
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