1HZ8


Conserved Protein Domain Family
EGF

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pfam00008: EGF (this model, PSSM-Id:333761 is obsolete and has been replaced by 394967)
Click on image for an interactive view with Cn3D
EGF-like domain
There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
Statistics
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PSSM-Id: 333761
Aligned: 67 rows
Threshold Bit Score: 26.9661
Created: 18-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1HZ8_A    5 CLD--NNggCSHV--CNDLK-----IGYECLCPDGfq-lVAQRR 38   human
P20736  209 CKTkeAGfvCKHG--CRSTG-----KAYECTCPSGstvaEDGIT 245  southern cattle tick
Q14766 1625 CGIl-NG--CE-NgrCVRVQ-----EGYTCDCFDG----YHLDT 1655 human
P06579  143 CFD--NN--CEYQ--CQPVGr----SEHKCICAEG----FAPVP 172  cattle
P07996  650 CTD--GThdCNKNakC-NYLghysdPMYRCECKPG----YAGNG 686  human
P14543  672 CYI--GThgCDTNaaCRPGPr----TQFTCECSIG----FRGDG 705  human
P01133  401 CPR--NVseCSHD--CVLTS-----EGPLCFCPEGsvleRDGKT 435  human
Q91VN0  298 CEE--DNggCSHL--CLLSPr---ePFYSCACPTGvqlqDNGKT 334  house mouse
Q91VN0  604 CAD--GNggCSHL--CFFTP-----RATKCGCPIGlellSDMKT 638  house mouse
P15216  256 CSQ--GTndCNENgeCVEED-----GKYWCECGEG----YEENE 288  purple sea urchin
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