1BLA,1NUN,4CJM,1QQK


Conserved Protein Domain Family
FGF

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pfam00167: FGF 
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Fibroblast growth factor
Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.
Statistics
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PSSM-Id: 333894
View PSSM: pfam00167
Aligned: 56 rows
Threshold Bit Score: 101.857
Threshold Setting Gi: 313229116
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1BLA_A        28 DPKRLYCKNg-GFFLRIHPDGRVDGVREKSDPHIKLQLQAE----ER-G--VVSIKGVSANRYLAMKEDGRLLA---S-- 94  human
Q28XC7        83 DEYVLTLKKhnDRALHINAHGKV--TAEDISLAQSFTMDSVgdalSVdF--KITIYAKDVDYYLCFHQ-GRLVG---K-- 152 Drosophila pseu...
Q6SJP8        53 RVYQLYSRTs-GKHVQIRG-HRVSATADDGNSYARLYVETD----TFgS--RVRIKGAESGRYLCMNRRGKLVG---K-- 119 zebrafish
EMP25717     374 RTYQLYSRTs-GKHVQVLDNKKINAMAEDGDAHAKLIVETD----TF-Gs-RVRIKGAETGFYICMNKKGKLIG---K-- 441 green sea turtle
CAF90913      30 RVYQLYSRTs-GQHVQIQG-RRVTATAADGSPHARLFVETD----SF-Gs-RVRIRGAESGRYLCMNRKGKLVA---K-- 96  spotted green p...
XP_001621706  53 KIAFLYSSNs-GKFVRIHS-AHADGAGNRQENKAKLIIEST----AFgG--QVRVRSFHDNKYLCITRHGDISIeesV-- 122 starlet sea ane...
XP_001628844  45 RHVRIYSRSs-KWYLRVAGSKIDARSKTTDDPNAVMVQESL----SInGtiRVRLRSLVENTYICVTKDGKLTL---E-- 114 starlet sea ane...
XP_001635198  41 RETQLYSRSs-RGHLRIFN-RQIDAEGKDGDPYAKLILESD----TFgG--RVKIKGDKTKHYLCIKKDGRLTS---R-- 107 starlet sea ane...
BAC55965      55 RYYEIYAKAt-SSRVQILG-KRVNAKGVRGNKYSKMAILST----SFgG--RIMIQGVETGRVLCMNRKGRLVG---Kvl 123 Pacific transpa...
NP_001027648  56 RYCEIYSKRt-SNHIRILG-KKVDGRGRRGSNHAKLIIHSK----GLwG--RIMIQGVQTERFLCMNKRGRLVG---Kny 124 vase tunicate
1BLA_A        95 -KSV-TD-ECFFFERLESNNYNTYRSRKYTS-WYVALKRTGQYKLGS--KTGPGQKAILF---L 149 human
Q28XC7       153 -RNA-TN-DCHFRESLDHGYYQFTHAY--NPvLHVGIKRNFRPIGPRdlERPNRMRNACF---L 208 Drosophila pseudoobscura
Q6SJP8       120 -PNG-RGrDCIFTEIVLENNYTALENARH-EgWFVAFTRKGRPIRAS--KTRQNQREVHFikrL 178 zebrafish
EMP25717     442 -SNGkGK-DCVFTEIVLENNYTALQNAKY-EgWYMAFTRKGRPRKGS--KTRQHQREVHF---M 497 green sea turtle
CAF90913      97 -PNGeSR-ECIFSEIVLENNYTAFQNAKY-EgWYVAFSRKGRPIKAS--RTRENQREVHF---I 152 spotted green pufferfish
XP_001621706 123 -LGR-SLdRCAFIQK-QQKGFTVFISKIH-KtWALGVRNDGRIKPAR--KTTSTQRAAHF---L 177 starlet sea anemone
XP_001628844 115 -DNG-ASqNCQFLEGY-RKGFTQFRSMYR-NnWYLGFKKSGNIKLPK--NTTKSQTASLF---L 169 starlet sea anemone
XP_001635198 108 -KIP-KSpKCVFKEAYTDDFFTQFISAYN-PkWMITVSKKGHTRPGF--KGRNGSRSVQF---I 163 starlet sea anemone
BAC55965     124 rRAK-HDlKCQFNDLMMPNLFDYFTNVAH-PkWYVAFNSHGRPKKGP--TTKLGQVETMF---L 180 Pacific transparent sea squirt
NP_001027648 125 rKAI-NDpKCLFFEEMLENYFDAFSNSKF-RdWHIGFHSNGRPKRGP--HTKEIGTDEMFikkc 184 vase tunicate
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