4EAZ


Conserved Protein Domain Family
Vg_Tdu
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pfam07545: Vg_Tdu (this model, PSSM-Id:336735 is obsolete and has been replaced by 462203)
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Vestigial/Tondu family
The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Scalloped (Sd) interacts with Vestigial (Vg) to form a complex, which binds DNA through the Sd TEA/ATTS domain. The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wing outgrowth when ectopically expressed. This short conserved region is needed for interaction with Sd.
Links
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Statistics
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PSSM-Id: 336735
Aligned: 18 rows
Threshold Bit Score: 53.4947
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4EAZ_C        16 TEWNAGSVIFTYFEGDINSXVDEHFSRALRN 46  house mouse
Q99NC0        21 TEWNAGSVIFTYFEGDINSMVDEHFSRALRN 51  house mouse
Q8BGW8        78 EYINSRCVLFTYFQGDISSVVDEHFSRALSH 108 house mouse
XP_002128412 108 hHISSRCVMFNYFDGETSNEVDEHFTRALNH 138 vase tunicate
XP_002128438  42 EYIRSRCYLVTYFKGHPRDKVDEHFNRSLRH 72  vase tunicate
ETE64059      20 TEWGAHYMVLTYFQGDTNSMVDEHFSRALSi 50  king cobra
XP_014740483  20 TEWGSQSVVFTYFQGDINSMVDQHFSRALGN 50  common starling
KGL72507      20 TEWGSQCVVFTYFQGDINSVVDEHFSRALSN 50  Tinamus guttatus
XP_012408758  25 tERSSRYVLFTYFQGDINSVVDEHFSRALSN 55  Tasmanian devil
XP_002932640  20 TELGSRCVVFTYYQGDINSVVDEHFSRALRT 50  western clawed frog
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