3B0O,1NF5,4L41


Conserved Protein Domain Family
LYZ_LA

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cd16898: LYZ_LA 
Click on image for an interactive view with Cn3D
alpha lactalbumin
alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.
Statistics
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PSSM-Id: 340384
View PSSM: cd16898
Aligned: 8 rows
Threshold Bit Score: 171.848
Threshold Setting Gi: 27574176
Created: 6-Sep-2016
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1: Ca binding site [ion binding site], 5 residue positions
Conserved feature residue pattern:K D [DE] D DClick to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
3B0O_A         1 MQFTKCELSQLLKdi--dGYGGIALPELICTMFHTSGYDTQaIVENNeSTEYGLFQISNKLWCKSSQvp---qsRNICDI 75  human
1NF5_A         1 TELTKCKVSHAIKdi--dGYQGISLLEWACVLFHTSGYDTQaVVNDNgSTEYGLFQISDRFWCKSSEfp---esENICGI 75  house mouse
4L41_A         2 KQFTKCELSQLLKdi--dGYGGIALPELICTMFHTSGYDTQaIVENNeSTEYGLFQISNKLWCKSSQvp---qsRNICDI 76  human
400171         1 RIFQICELSRVLKenglgGFHGVSLEEWLCVIFHESGYDSQaLNYYNgSSSHGLFQINQPYWCDDXDsestepsVNACQI 80  duckbill platypus
729922        20 IDYRKCQASQILKeh--gMDKVIPLPELVCTMFHISGLSTQaEVNNHsNKEYGIFQISNNGWCAEKQed---vaNSVCGI 94  tammar wallaby
XP_007503004  41 RELTKCELIQDLKnhgmdKYEDFHLNEMICVTFHSSGFNTQiKVSNNgNTEYGIFQISNNGWCAEKQed---vaKSTCGI 117 gray short-tail...
XP_008101885  19 IKYEKCELYDELMkhgldGFNGLGIGHWICLTLFATGYNTNhYEYTRgHPYYGLFYLSGLEWCNNERhl----sKNLCKI 94  green anole
ETE61518      33 IIFDICSFSAILKengleGFPGTTIAEWICLVFHSSGFDTSaLNVGPrATNHGIFLLSAKWWCDDFKtp---haRNYCNL 109 king cobra
Feature 1           #  # #  ##                                      
3B0O_A        76 SCDKFLDDDITDDIMCAKKILDI-KGIDYWLAHKALCTE---KLEQWL--C 120 human
1NF5_A        76 SCDKLLDDELDDDIACAKKILAI-KGIDYWKAYKPMCSE---KLEQWR--C 120 house mouse
4L41_A        77 SCDKFLDDDITDDIMCAKKILDI-KGIDYWLAHKALCTE---KLEQWL--C 121 human
400171        81 PCSKLLDDDILDDIECAKKIVKEpKGITAWEAWQPFCNS---DLDQWK--C 126 duckbill platypus
729922        95 LCSKFLDDDITDDIECAKKILQLpEGLGYWKAHETFCIE---DLDQWR--C 140 tammar wallaby
XP_007503004 118 LCSKLLDDDINDDIVCAKKIIEQpKGIDYWKAHKTFCLE---NLDQWR--C 163 gray short-tailed opossum
XP_008101885  95 HCEKFLDDDIRDDIACAKKVAASkDGMLSWKPFRDYCRHpmpEVVYWE--C 143 green anole
ETE61518     110 SCEALRDDNITDDIQCAKRVVEKsKGFAAWAAWRIHCKGq--DLKKYIagC 158 king cobra

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