Conserved Protein Domain Family
HATPase_MORC-like

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cd16931: HATPase_MORC-like 
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.
Statistics
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PSSM-Id: 340408
Aligned: 7 rows
Threshold Bit Score: 183.764
Created: 14-Sep-2016
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           #   #  #                          # # # ##                    
NP_056173      18 FLHTNSTSHt-wPFSAVAELIDNAYDPDvNAKQIWIDktvi----ndhiCLTFTDNGNGMTSDKLHKMLSFGFSDKvtmn 92   human
NP_001307140   19 YLESNSTSHt-wPFSAVAELIDNASDPGvTAKNIWIDvvtv----rdqlCLSFTDNGSGMTPSKLHKMLSFGFTEKgssk 93   zebrafish
NP_001003994   18 YLHTNSTTHe-fLFGALAELVDNSRDANaTRIDIYTEkrpdl---rggfMLCFLDDGTGMEPSEATHVIQFGKSSKrfpe 93   zebrafish
NP_498104      22 FLKSNSHTHi-gPLSAIAELVDNAYDADaRDLHIDFLdin------neqFLELRDDGLGMAREEALHAITFGHSAKcsy- 93   Caenorhabditi...
NP_173344     118 FLHSNATSHk-wAFGAVAELLDNAVDEIqNGATFVIVdkttnp-rdgatALLIQDDGGGMDPQAMRHCMGFGFSDKksd- 194  thale cress
XP_006573513  172 YLKTLGQVHsgwIFGGIAELVDNSRDAKaTKMDIFVDlinlkksgkdvpMLSVIDDGNGMNHAEVMKMVSFGHKQSdkdd 251  soybean
Q86VD1         17 FIHANSTTHs-fLFGALAELLDNARDAGaERLDVFSVdnekl---qggfMLCFLDDGCGMSPEEASDIIYFGRSKKrlst 92   human
Feature 1                  ####            # #            ## #    
NP_056173      93 g-hvpvGLYGNGFKSGSMRLGKDAIVFTKnges----msvGLLSQTYL 135  human
NP_001307140   94 sshqpiGVYGNGFKSGSMRLGRDALIFTKnggc----qsvGMLSQSFL 137  zebrafish
NP_001003994   94 --sthiGQYGNGLKSGSMRIGKDFILFTKkdek----ltcLFLSRTFH 135  zebrafish
NP_498104      94 ----kiGRYGNGLKSGAFHLGRELLLVTKkdgi----itaLLISHRFH 133  Caenorhabditis elegans
NP_173344     195 ---saiGRYGNGFKTSTMRLGADVIVFSRhsknqtltqsiGLLSYTYL 239  thale cress
XP_006573513  252 --kdhiGKFGVGFKTGAMRLGRDVLVLTQttns----rslAFLSQSLN 293  soybean
Q86VD1         93 --lkfiGQYGNGLKSGSMRIGKDFILFTKkeet----mtcVFFSQTFC 134  human

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