Conserved Protein Domain Family
DCX_DCLK3
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cd16111: DCX_DCLK3 
Doublecortin-like domain found in doublecortin-like kinase 3 (DCLK3)
DCLK3 is a member of doublecortin (DCX) protein family. It functions as a microtubule-associated protein (MAP). DCLK3 contains only one N-terminal doublecortin domain (DCX), unlike DCLK1 and DCLK2 which each have two conserved DCX domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK3 has a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases.
Links
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Statistics
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PSSM-Id: 340528
Aligned: 10 rows
Threshold Bit Score: 144.115
Created: 29-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative DCX-stabilized microtubules [polypeptide binding site]
Evidence:
  • Comment: DCX binds the corner of four tubulin dimers and stabilizes both lateral and longitudinal lattice contacts.
  • Comment:Mutations in N- and C- terminal of DCX domain cause severe neuronal migration disorders in humans.
  • Comment:based on the structural evidence that human doublecortin repeat in complex with mammalian tubulin, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #          # ##     #    ## #       #       ### ##  #                          #
Q8BWQ5         95 KPRVVTVVKLGG-QPLRKATLLLNRRSVQTFEQLLSDISEALGfPRWKNDRVRKLFTLKGREVKSVSDFFREGDAFIAMG 173  house mouse
ELT91299      145 KPKVITVVRNSG-KPRTSVKILLNRRSVQSYEQLMKDITEAFG-PKWKNNKMRKLFTVRGREVKGISDFFREDDVFIGIG 222  Capitella teleta
XP_002604088 1540 KPKVITVVRNGD-RPRTKITILLNRRSVQTFEQLIADISEALGqPRWKNNHVKKLYNLKGREVKGIGDFFREDDMFIATG 1618 Florida lancelet
XP_002130286  211 KPKVVTVVRAGQiRPHKKITILLNRRAVQTYEQLVSDISEALGqPKWKNDHIRRLYTLKGREIRSVSDFFREDDVFIAVG 290  vase tunicate
XP_007902284   84 KPKVVTVVKAGR-QPYKKITILLNRRCMQTFEQLIADISEALGhPCWKSQSVKTLYTLKGKEIRSVSDFFRGDDMFIAAG 162  elephant shark
EKC41711       95 KPKVVTIVRNGH-KPRNNVKILLNRRSVQSFEQLMADISEAFG-PKYKNNKVKKLFSIRGREVQGISDFFRDDDVFIGVG 172  Pacific oyster
XP_003207333   73 KPRIITVVRPCG-HMLRKITLLLNRRSVQTFEQLMADISEALGfPRWKNDRVRKLYSLRGREIQSVSDFFREGDAFIALG 151  turkey
OCT76043       38 KPRIITVVKPGS-HPLKKITLLLNKRSVQTFEQLVADISEALGfPRWKNDRVRKLYNLRGKEIRSISDFFRGDDIFIALG 116  African clawe...
XP_014346021    9 KPRVITVVKPGR-QSLRKIKLLLNRRSVQTFEQLVADISEALGfPQWKNDRIRKLYSLKGKEIRSISDFFRGEEVFIAAG 87   coelacanth
XP_013420903  203 KPKVITVVRYGPpGPRTTVRILLNRRSVQSYEQLMGDIAESFG-SRWRGQRIVKLYSLRGKEVNGVSDFFRDDDVFIATS 281  Lingula anatina

Feature 1               
Q8BWQ5        174 KEPLTL 179  house mouse
ELT91299      223 NEQLSS 228  Capitella teleta
XP_002604088 1619 REQITT 1624 Florida lancelet
XP_002130286  291 REQLTT 296  vase tunicate
XP_007902284  163 REKLTM 168  elephant shark
EKC41711      173 GESLTE 178  Pacific oyster
XP_003207333  152 REPLTL 157  turkey
OCT76043      117 REQLTT 122  African clawed frog
XP_014346021   88 RNSLNL 93   coelacanth
XP_013420903  282 QEMIPL 287  Lingula anatina

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