5IP4


Conserved Protein Domain Family
DCX2
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cd17069: DCX2 
Dublecortin-like domain 2
Members in doublecortin (DCX) gene family are microtubule-associated proteins (MAPs). Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its protein domains can occur in double tandem or as a single repeat. The first repeat of DCX domain has a stable ubiquitin-like tertiary fold. Proteins with DCX double tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK).
Links
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Statistics
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PSSM-Id: 340589
Aligned: 13 rows
Threshold Bit Score: 151.766
Created: 25-Jun-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DCX-stabilized microtubules [polypeptide binding site]
Evidence:
  • Comment: DCX binds the corner of four tubulin dimers and stabilizes both lateral and longitudinal lattice contacts.
  • Comment:Mutations in N- and C- terminal of DCX domain cause severe neuronal migration disorders in humans.
  • Comment:based on the structural evidence of the human doublecortin repeat in complex with mammalian tubulin, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #          ###     #    ## #       #        ##  #                          #  
5IP4_D         7 FVRPKLVTIIRSGVKPRKAVRVLLNKKTaHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLhDFFGDDDVFIACGPE 86  human
ELT89101     180 YITPRLVTVVRNGTKPRKAVRILLNKKTaHNFQQVMNDITSTIKLDTGAVRKLFTLGGKQITCLrDFFGEESMFIAYGNE 259 Capitella teleta
B4IT27       311 VVHPRIVTLIRSGTKPRRIMRLLLNKRNsPSFDHVLTAITQVVRLDTGYVRKVFTLSGISVVQLsDFFESDDVFFAYGTE 390 Drosophila yakuba
XP_002611681 178 YIRPKLITVIRHGTKPRKAVRILLNKKTaHSFNQVLNDITLAIKLDTGIVRKIFTIGGKQVTCLqDFFEDDDIFVAYGPE 257 Florida lancelet
NP_001161528 198 FIKPKLVTIIKNGPKPRKAVRILLNKKTaHSFEQVLNDITDAIKLDSGAVRKLYTVDGRQVACLqDFFKEDDVFIAYGPE 277 Saccoglossus ko...
XP_792471    182 FIKPRLVTVIKSGAKPRKAVRILLNKKTaHSFEQVLTDITEAIKLDSGAVRKLYTLDGRQIHSLqGFFKDDDVFIAYGQE 261 purple sea urchin
XP_002125182 199 FIKPKLVTIIRSGVKPRKAVRILLNKKTaHSLEQVLNDVTKAIKLDTGAVRKVYTLQGKQVQSLqDFFGNDDIFIAYGHE 278 vase tunicate
EKC37923     186 YVKPKLVTVIRNGPKPRKAVRVLLNKKTaQSFDQVLADITEAIKLDSGAVRKIFTLDGRQVSTLrDFFGEETVYIAYGQE 265 Pacific oyster
EFX77430     169 YMKPRLITIIRNGSRPRKAVRLLLNKKTaFTYEQVLSDITEAIRPDSGTVRKLYTADGRQVGCLaDFFGPDFIFIAYGNE 248 common water flea
NP_499571    336 FVFPRIIKVIRNGVKPRRISRHLLNKKTaRSFDQVLRDLTFVVKLDSGAIRKLFTLSGRPVLSLqDFFRDDDVFVAYGGN 415 Caenorhabditis ...
O15075       182 FIRPKLVTIIRSGVKPRKAVRILLNKKTaHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLqDFFGDDDIFIACGPE 261 human
Q8N568       193 FIKPKLVTVIRSGVKPRKAVRILLNKKTaHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLqDFFGDDDVFIACGPE 272 human
XP_013416369 192 YIRPKLVTIIRNGTKPRKAVRILLNKKTaHSFEQVLNDVTEAIKLDTGAVRKIFTLDGRQVTNLsDLFKDDSVFLAYGPE 271 Lingula anatina

Feature 1            
5IP4_D        87 KFRY 90  human
ELT89101     260 KYAL 263 Capitella teleta
B4IT27       391 RINT 394 Drosophila yakuba
XP_002611681 258 KYSS 261 Florida lancelet
NP_001161528 278 KYSH 281 Saccoglossus kowalevskii
XP_792471    262 RFCH 265 purple sea urchin
XP_002125182 279 KLSQ 282 vase tunicate
EKC37923     266 KLCQ 269 Pacific oyster
EFX77430     249 KFSH 252 common water flea
NP_499571    416 EKMA 419 Caenorhabditis elegans
O15075       262 KFRY 265 human
Q8N568       273 KFRY 276 human
XP_013416369 272 RYSM 275 Lingula anatina

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