Conserved Protein Domain Family
Ubl_TMUB1

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cd17131: Ubl_TMUB1 
ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)
TMUB1, also termed dendritic cell-derived ubiquitin-like protein (DULP), or hepatocyte odd protein shuttling protein, or ubiquitin-like protein SB144, or HOPS, is highly expressed in the nervous system. It is involved in the termination of liver regeneration and plays a negative role in interleukin-6-induced hepatocyte proliferation. The overexpression of Tmub1 has been shown to play a role in the inhibition of cell proliferation. TMUB1 has also been implicated in the regulation of locomotor activity and wakefulness in mice, perhaps acting through its interaction with CAMLG. It also facilitates the recycling of AMPA receptors into synaptic membrane in cultured primary neurons. TMUB1 contains transmembrane domains and a ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold.
Statistics
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PSSM-Id: 340651
Aligned: 5 rows
Threshold Bit Score: 147.282
Created: 23-Nov-2016
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
key conservedkey conserved
Feature 1: key conserved lysine K27, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K27 (Ub numbering) is a lysine conserved in the Ubl_ubiquitin_like family; it is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering); may have other functions, for example for NEDD8 it is involved in the mechanism of protein neddylation

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   #                                           
Q9BVT8       102 PLVLRLKFLNDSEQVARAWPhDTIGSLKRTQFpgrEQQVRLIYQGQLLGddtQTLGSLHLPPNCVLHCHVS 172 human
EMP26311     131 TIVLRLKFLNDTERLATVCPeDTVGSLKRAHFpgqEHQVRLIYQGQLLRddaQSLAALHLTHNSVLHCHVS 201 green sea turtle
Q6P135       148 NMVLRLKFLNDTERTAQVNPqDTIGYIKRTYFagqEHQVRLIYQGQLLQddsQTLASLNLADNSVLHCHIS 218 zebrafish
XP_005994276 162 GMVLRLKFLNDTEKLARVKLdDTIGYLKRTYFpgqEHQVRLIYQGQLLRedsQTLASLHLTDNCVLHCHIS 232 coelacanth
XP_007908933 143 YILLRLKFLNDTERIARVKAeDTVGHIKRTYFpdqEHQVRLIYQGQLLGdnhQTLASLHILNNCVIHCHIS 213 elephant shark

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