Conserved Protein Domain Family
RBD1_RGS14

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cd17137: RBD1_RGS14 
Ras-binding domain (RBD) 1 of regulator of G protein signaling 14 (RGS14)
RGS12 (regulator of G protein signaling 14) is a RGS protein with a multidomain structure that allows it to interact with binding partners from multiple signaling pathways. RGS proteins belong to a large family of GTPase-accelerating proteins (GAPs) which act as key inhibitors of G-protein-mediated cell responses in eukaryotes. RGS14 contains an N-terminal RGS domain, two tandem Ras-binding domains (RBDs) and a G protein regulatory (GPR, also referred to as a GoLoco) motif. RGS14 binds activated H-Ras-GTP through its first RBD and interacts with Rap2-GTP and RAF kinases by the second tandem RBD. RBD is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. RGS14 modulates neuronal physiology and all of its binding partners have roles in synaptic plasticity.
Statistics
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PSSM-Id: 340657
Aligned: 6 rows
Threshold Bit Score: 126.848
Created: 25-Jun-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
key conserved
Feature 1:key conserved lysines
Evidence:
  • Comment:2 (K33/R, K48/R, Ub numbering) of the 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering) are conserved for most members of this family; may have roles other than chain linkage

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #                 #                    
O43566       302 KYCCVYLPDGTASLALARpGLTIRDMLAGICEKRGLSLPDIKVYLVG-NEQALVLDQDCTvLADQEVRLEN 371 human
XP_005992461 463 KYCCVYLPDGTASLASVRpGLTIQEMLSGICEKRGISIIDVKAYLAEnDKKPLKLDQESTvLTDLEVRLEN 533 coelacanth
XP_007889710 371 KYCCIYLPDGTSSLVKVRaGLTIRDLLLNICERHGIPMAATSIYLTRnEKKPLVLDQDCMiLSDQELRVEK 441 elephant shark
NP_958461    320 KYCCVYLPDGTASLVSARaGLSLRDMISSLCEKRAFPLRDVLLYLRG-KDKPLSLDQDCSmFGDQQLSLEL 389 zebrafish
AAH73229     305 KYCCVYLPDGTASLTAVKpGLTIRDMLVGVCEKRGYCLTDVKVFLVGnEEKALALDQECLvLTDQEVRLEN 375 African clawed frog
KFV76980     271 KYCCVYLPDGTASLASVRpGQSIRDMLAGICEKRGFSLPDIKVYLVGnEQKALVLDQECSvLADQEVKLEN 341 Struthio camelus australis

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