Conserved Protein Domain Family
MFS_SLCO3_OATP3

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cd17402: MFS_SLCO3_OATP3 
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters
The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Statistics
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PSSM-Id: 340960
View PSSM: cd17402
Aligned: 6 rows
Threshold Bit Score: 806.459
Threshold Setting Gi: 113681162
Created: 15-Mar-2016
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative chemical substrate binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of MFS transporters with bound substrates, substrate analogs, and/or inhibitors
  • Comment:since MFS proteins facilitate the transport of many different substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides, the residues involved in substrate binding may not be strictly conserved among superfamily members
  • Comment:the substrate binding site or translocation pore has access to both sides of the membrane in an alternating fashion through a conformational change of the MFS transporter

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      ##  ##  #                               #                         
Q9UIG8        39 IKIFLVSECALMLAQGTVGAYLVSVLTTlerRFNLQSADVGVIASSFEIGNLALILFVSYFGArghRPRLIGCGGIVMAL 118 human
NP_001038653  27 IKIFLVAECALMLAQGTVGAYLVSVLTTlerRFNLQSADVGVIASSFEIGNLALILFVSYFGAkahRPRLIGCGGIVMAL 106 zebrafish
XP_413876     34 IQLFLVSECALMLAQGTVGAYLVSVLTTlerRFNLQSADVGVIASSFEIGNLALILFVSYFGArghRPRLIGCGGIVMAL 113 chicken
XP_002933360  36 IKIFLVSECALMLAQGTVGAYLVSMLTTlerRFNLQSADVGVIASSFEIGNLALILFVSYFGArghRPRLIGCGGIVMAL 115 tropical clawed...
XP_005994028  32 IKIFLVSECALMLAQGTVGAYLVSVLTTlerRFNLQSADVGVIASSFEIGNLALILFVSYFGArghRPRLIGCGGIVMAL 111 coelacanth
XP_007906532  27 IKIFMLSECALMLAQGTVGAYLVSVLTTlerRFNLQSADVGVIASSFEIGNLALILFVSYFGAkghRPRLIGCGGIVMAL 106 elephant shark
Feature 1                                                                                ## ###  
Q9UIG8       119 GALLSALPEFLTHQYKyeageirwgaegrdvcaangsggdegpdpdlicrnrtaTNMMYLLLIGAQVLLGIGATPVQPLG 198 human
NP_001038653 107 GALLSALPEFLASQYKitdtwskdqgrdvcs---------ntskadepcgnranTNMMYLLLIGAQVLLGIGATPVQPLG 177 zebrafish
XP_413876    114 GALLSALPEFLTHQYEyesgeirwgaegrdvcaangstsdegpdpdlicrnrtaTNMMYLLLIGAQVLLGIGATPVQPLG 193 chicken
XP_002933360 116 GALLSALPEFLTHQYKyepgeirwgaegrdicsindtssgeipdpdiicsntatTNMMYLLLIGAQVLLGIGATPVQPLG 195 tropical clawed...
XP_005994028 112 GALLSALPEFLTHQYEyksgeirwgtegrdvcsingssddngpgpelicgnrtsTNMMYLLLIGAQVLLGIGATPVQPLG 191 coelacanth
XP_007906532 107 GALLSALPEFLTHQYEyepgdspwgldgqglcatn-isgvsededgeiicrrtsTNMMYLLLIGAQVLLGIGATPVQPLG 185 elephant shark
Feature 1        #                   #  ##  #                                                    
Q9UIG8       199 VSYIDDHvrrkdsslyiGILFTMLVFGPACGFILGSFCtkiyvdavfidtsnlditpddprwIGAWWGGFLLCGALLFFS 278 human
NP_001038653 178 VSYIDDHvrkkdsslyiGILFSTLVFGPACGFILGSVCtnfyvdalfidttqlnitpddprwIGAWWGGFLICGALLFFS 257 zebrafish
XP_413876    194 VSYIDDHvrrkdsslyiGILFTMLVFGPACGFILGSFCtkiyvdavfidtsklditpddprwIGAWWGGFLLCGALLFFS 273 chicken
XP_002933360 196 VSYIDDHvrrkdsslyiGILFTMLVFGPACGFILGSFCtkiyvdafltdtsklditpddprwIGAWWAGFLLCGVLLFFS 275 tropical clawed...
XP_005994028 192 VSYIDDHvrrkdsslyiGILFTMLVFGPACGFILGSLCtkfyvdaifidtsklditpddprwIGAWWGGFLLCGALLFFS 271 coelacanth
XP_007906532 186 VAYIDDHvrrkdsslyiGILFTTLVFGPTCGFILGSLCtkiyvdavfidtsklditpedprwIGAWWGGFLLCGALLFFS 265 elephant shark
Feature 1                                                                                        
Q9UIG8       279 SLLMFGFPQSLpphsepameseqamlsereyer----pkpsngvlrhplepdssascfQQLRVIPKVTKHLLSNPVFTCI 354 human
NP_001038653 258 ALFMFGFPQSLpskemegvpeseqamlpaslsqdfekskpsngvvqnyqpnsnslsccQQLRVIPKVTKHLLSNPVFTCI 337 zebrafish
XP_413876    274 SLPMFGFPQSLpprpehageseqamlpdrdyer----pkpsngvlrhaldaessttcfQQLRVIPKVTKHLLSNPVFTCI 349 chicken
XP_002933360 276 SLLMFGFPQSLspridrseeseqtmlpdteyer----pkpsngvlrhysetedgtscfQQLRVIPKVTKHLLSNPVFTCI 351 tropical clawed...
XP_005994028 272 ALLMFGFPQSLspqgdrsteseqtmlpdreyer----akpsngvlrhplhadkgsscfQELRVIPKVTKHLLSNPVFTCV 347 coelacanth
XP_007906532 266 ALFMFGFPQSLaiknelvpeseqimlprefe-------gqkpsngvaqledgtstscfQQLRVIPKVTKHLLANPVFTCI 338 elephant shark
Feature 1           #  ##  ###  #                            #   #                               
Q9UIG8       355 ILAACMEIAVVAGFAAFLgkyleqqfnltTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTAC 434 human
NP_001038653 338 VLAACMEIAVVAGFAAFLgkyleqqfnltTSSANQLLGMTAIPCACLGIFLGGLLVKKLNLSALGAIRMAMLVNLISTAC 417 zebrafish
XP_413876    350 ILAACMEIAVVAGFAAFLgkyleqqfnltTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTAC 429 chicken
XP_002933360 352 VLAACMEIAVVAGFAAFLgkyleqqfnltTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTAC 431 tropical clawed...
XP_005994028 348 VLAACMEIAVVAGFAAFLgkyleqqfnltTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMMVNLVSTAC 427 coelacanth
XP_007906532 339 VLAACMEIAVVAGFAAFLgkyleqqfnlsASSANQLLGMTAIPCACLGIFLGGLLVKKLNLSALGAVRMAMLVNLISTAC 418 elephant shark
Feature 1                 ##   #   #                                                             
Q9UIG8       435 YVSFLFLGCDTGPVAGVTVPYGNstapgs-aldpysPCNNNCECQTDSFTPVCGADGITYLSACFAGC-----------N 502 human
NP_001038653 418 YVSFLFLGCDTGPVAGVTVAYGNetlqvg--qtpeaPCMSHCNCYTSSVSPVCGSNGVTYLSSCFAGCtraistglpapL 495 zebrafish
XP_413876    430 YVSFLFLGCDTGPVAGVTVPYGNnstpts-sldpysPCNNNCECQTDSFTPVCGADGVTYLSACFAGC-----------S 497 chicken
XP_002933360 432 YVSFLFLGCDTGPVAGVTVPYGNisvpga-sveryaSCNTDCECQTDSFTPVCGADGITYLSACFAGC-----------T 499 tropical clawed...
XP_005994028 428 YVSFLFLGCDTGLVAGVTVPYGNdsapgsppsgpsvSCNKACDCHVDSFSPVCGADGITYLSACFAGC-----------T 496 coelacanth
XP_007906532 419 YISFLFLGCDNGPIAGVTVPYGNdtgsge-dldpfaPCNSECDCTMAIYSPVCGSDGITYLSACFAGC-----------S 486 elephant shark
Feature 1           #  ##  ##  #                                              
Q9UIG8       503 STNLTGCACLTTVPAENATVvPGKCPSPGCQeaFLTFLCVMCICSLIGAMAQTPSVIILIR 563 human
NP_001038653 496 SQNLSGCACISGYNDFATAV-PGKCPRPGCQeaFLTFLCVICGCSMIGAMAQTPSVIILIR 555 zebrafish
XP_413876    498 STNLSGCSCLSSVPAENATVvPGKCPSPGCEeaFLTFLCVMCVCSMIGAMAQTPSVIILIR 558 chicken
XP_002933360 500 KMNLAGCSCLSSVPVENNTVvPGKCPSPGCQeaFLTFLCVMCVCSMIGAMAQTPSVIILIR 560 tropical clawed frog
XP_005994028 497 STNLTGCVCLSTMLAENTTVvTGKCPSPGCQdaFLIFLCVMCVCSMIGAMAQTPSVIILIR 557 coelacanth
XP_007906532 487 STNLSDCICLNIGSDENATAiPGKCPNPGCQeaFLTFMCVMCACSLIGAMAQTPAIMILIR 547 elephant shark

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