4ZW9,5C65,5EQG,4PYP


Conserved Protein Domain Family
MFS_GLUT_Class1

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cd17431: MFS_GLUT_Class1 
Click on image for an interactive view with Cn3D
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Statistics
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PSSM-Id: 340989
Aligned: 19 rows
Threshold Bit Score: 649.782
Created: 18-Jan-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
chemical
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:chemical substrate binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #   #                                                               
4ZW9_A         34 FAITVATIGSFQFGYNTGVINAPEKIIKEFITKTLTDkgnap-------------------------------------- 75   human
4PYP_A         14 LAVGGAVLGSLQFGYNTGVINAPQKVIEEFYTQTWVHryges-------------------------------------- 55   human
P14672         26 LAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGrqgpegp-----------------------------------s 70   human
P11168         12 FTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVplddrkainnyvinstdelpti-----sysmnpkptpwaeeet 86   human
P46896         13 LAVGGAVLGSLQFGYNTGVINRPQKVIEDFYNHTWLYryeep-------------------------------------- 54   chicken
NP_035530      14 LAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHrygep-------------------------------------- 55   African clawe...
XP_007910334   13 TAVGVAVIGSLQFGYNTGVINAPQKVIENFLNDTWIYrynep-------------------------------------- 54   elephant shark
Q90592         19 LSVFTAVLGFFQYGYSLGVINAPQKVIEAHYGRMLGAipmvrhatntsrdnatitvtipgteawgssegtlapsagfedp 98   chicken
NP_001036186   11 LAVFTAALGSLQMGYSLGVINAPQKVIERHYARSLGVynedlarseggn--------------------------gtehe 64   zebrafish
Q8IRI6         15 YSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDryged-------------------------------------- 56   fruit fly
Feature 1                                                                                         
4ZW9_A         76 -psevlLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKvaksvEMLILGRLVIGLFCG 154  human
4PYP_A         56 -ilpttLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKlgksfEMLILGRFIIGVYCG 134  human
P14672         71 sippgtLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANaaasyEMLILGRFLIGAYSG 150  human
P11168         87 vaaaqlITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGFSKlgpshILIIAGRSISGLYCG 166  human
P46896         55 -ispatLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMSNILAFLAAVLMGFSKmalsfEMLILGRFIIGLYSG 133  chicken
NP_035530      56 -ipsttLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVAAVLMGFSKlgksfEMLILGRFIIGVYCG 134  African clawe...
XP_007910334   55 -isqgtLTSLWSLSVSIFSVGGMFGSFSVGLFVNRFGRKNSMLMNNLLAFIASALMGFSKlagsyEMLIMGRFFIGIYSG 133  elephant shark
Q90592         99 tvsphiLTMYWSLSVSMFAVGGMVSSFTVGWIGDRLGRVKAMLVVNVLSIAGNLLMGLAKmgpshILIIAGRAITGLYCG 178  chicken
NP_001036186   65 kptdpsVVMYWSLSVAIFSVGGMLSSFLVSFVGDFRGRIKGMLAINVLAITAGLLMGLAKmgtphLMVIAGRAIMGLYCG 144  zebrafish
Q8IRI6         57 -iseefIQQLYSVAVSIFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKvshsyEMLFLGRFIIGVNCG 135  fruit fly
Feature 1                                   #  ##  #                                              
4ZW9_A        155 LCTGFVPMYIGEisptalRGAFGTLNQLGIVVGILVAQIFGLEFIlgseelWPLLLGFTILPAILQSAALPFCPESPRFL 234  human
4PYP_A        135 LTTGFVPMYVGEvsptalRGALGTLHQLGIVVGILIAQVFGLDSImgnkdlWPLLLSIIFIPALLQCIVLPFCPESPRFL 214  human
P14672        151 LTSGLVPMYVGEiapthlRGALGTLNQLAIVIGILIAQVLGLESLlgtaslWPLLLGLTVLPALLQLVLLPFCPESPRYL 230  human
P11168        167 LISGLVPMYIGEiaptalRGALGTFHQLAIVTGILISQIIGLEFIlgnydlWHILLGLSGVRAILQSLLLFFCPESPRYL 246  human
P46896        134 LTTGFVPMYVGEvsptalRGALGTFHQLGIVLGILIAQVFGLDLImgndslWPLLLGFIFVPALLQCIILPFAPESPRFL 213  chicken
NP_035530     135 LTTGFVPMYVGEvsptalRGALGTLHQLGIVVGILIAQVFGLDSImgnadlWPLLLSVIFIPALLQCILLPFCPESPRFL 214  African clawe...
XP_007910334  134 LTTGFVPMYVGEisptnlRGALGTLHQLGIVVGILIAQIFGLESLmgneslWPLLLGFIFIPSLVQCIAFPFCPESPRFL 213  elephant shark
Q90592        179 LSSGLVPMYVSEvsptalRGALGTLHQLAIVTGILISQVLGLDFLlgndelWPLLLGLSGVAALLQFFLLLLCPESPRYL 258  chicken
NP_001036186  145 LSSGLVPLYIGEispvkyRGAMGALHQLAIVIGILISQVIGLDFLlgndymWHILLGLSGAPAILQSLLLLVCPESPRYL 224  zebrafish
Q8IRI6        136 LNTSLVPMYISEiaplnlRGGLGTVNQLAVTVGLLLSQVLGIEQIlgtnegWPILLGLAICPAILQLILLPVCPESPRYL 215  fruit fly
Feature 1                                                                            ##   ##  #   
4ZW9_A        235 linrKEEENAKQILQRLWGTqdvsqDIQEMKDESARMSqeKQVTVLELFRvssYRQPIIISIVLQLSQQLSGINAVFYYS 314  human
4PYP_A        215 linrNEENRAKSVLKKLRGTadvthDLQEMKEESRQMMreKKVTILELFRspaYRQPILIAVVLQLSQQLSGINAVFYYS 294  human
P14672        231 yiiqNLEGPARKSLKRLTGWadvsgVLAELKDEKRKLEreRPLSLLQLLGsrtHRQPLIIAVVLQLSQQLSGINAVFYYS 310  human
P11168        247 yiklDEEVKAKQSLKRLRGYddvtkDINEMRKEREEASseQKVSIIQLFTnssYRQPILVALMLHVAQQFSGINGIFYYS 326  human
P46896        214 linrNEENKAKSVLKKLRGTtdvssDLQEMKEESRQMMreKKVTIMELFRspmYRQPILIAIVLQLSQQLSGINAVFYYS 293  chicken
NP_035530     215 linrNEENRAKSVLKKLRGTadvtrDLQEMKEEGRQMMreKKVTILELFRspaYRQPILIAVVLQLSQQLSGINAVFYYS 294  African clawe...
XP_007910334  214 linrNEENKAKSVLKKLRGTtdvssDLQEMKEESRQMMreKKVTIPELFRsplYRQPLLIAVVLQLSQQLSGINAIFYYS 293  elephant shark
Q90592        259 yiklGKVEEAKKSLKRLRGNcdpmkEIAEMEKEKQEAAseKRVSIGQLFSsskYRQAVIVALMVQISQQFSGINAIFYYS 338  chicken
NP_001036186  225 yikqGKVEDACKSLKRLKGDydtskDIAEMKAEKEEAMkeAKMSILRLLRssvYRQQLFVALMMHFSQQFSGINAIFYYS 304  zebrafish
Q8IRI6        216 litkQWEEEARKALRRLRASgsveeDIEEMRAEERAQQseSHISTMELICsptLRPPLIIGIVMQLSQQFSGINAVFYYS 295  fruit fly
Feature 1                                 #                                                       
4ZW9_A        315 TGIFkda--gvqEPIYATIGAGVVNTIFTVVSLFLVERaGRRTLHMIGLGGMAFCSTLMtvslllkdnyngMSFVCIGAI 392  human
4PYP_A        295 TSIFeka--gvqQPVYATIGSGIVNTAFTVVSLFVVQRaGRRTLHLIGLAGMAGCAILMtialalleqlpwMSYLSIVAI 372  human
P14672        311 TSIFeta--gvgQPAYATIGAGVVNTVFTLVSVLLVERaGRRTLHLLGLAGMCGCAILMtvallllervpaMSYVSIVAI 388  human
P11168        327 TSIFqta--gisKPVYATIGVGAVNMVFTAVSVFLVEKaGRRSLFLIGMSGMFVCAIFMsvglvllnkfswMSYVSMIAI 404  human
P46896        294 TSIFeks--gveQPVYATIGSGVVNTAFTVVSLFVVERaGRRTLHLIGLAGMAGCAILMtialtlldqmpwMSYLSIVAI 371  chicken
NP_035530     295 TSIFeka--gvqQPVYATIGSGIVNTAFTVVSLFVVERaGRRTLHLIGLAGMAGCAVLMtialallerlpwMSYLSIVAI 372  African clawe...
XP_007910334  294 TNIFaka--gvgQPVYATIGSGIVNTAFTVVSLFVVERaGRRTLHLIGLAGMGSCAVLMtialvlldqqswMSYLSIIAI 371  elephant shark
Q90592        339 TNIFqra--gvgQPVYATIGVGVVNTVFTVISVFLVEKaGRRSLFLAGLMGMLISAVAMtvglvllsqfawMSYVSMVAI 416  chicken
NP_001036186  305 TSIFqta--gvgQPVYATIGVGVVNIIFTLVSVLMVDRaGRRTLTLVGLGGMCCCAVAMtvglafqgayswMSYVSMVAI 382  zebrafish
Q8IRI6        296 TSLFmssglteeSAKFATIGIGAIMVVMTLVSIPLMDRtGRRTLHLYGLGGMFIFSIFItisflikemidwMSYLSVVAT 375  fruit fly
Feature 1               ##   #   #                      #   #                                     
4ZW9_A        393 LVFVAFFEIGPGPIPWFIVAelFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSaaHYLGAYVFIIFTGFLITFLAFTFFKV 472  human
4PYP_A        373 FGFVAFFEVGPGPIPWFIVAelFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYveQLCGPYVFIIFTVLLVLFFIFTYFKV 452  human
P14672        389 FGFVAFFEIGPGPIPWFIVAelFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYvaEAMGPYVFLLFAVLLLGFFIFTFLRV 468  human
P11168        405 FLFVSFFEIGPGPIPWFMVAefFSQGPRPAALAIAAFSNWTCNFIVALCFQYiaDFCGPYVFFLFAGVLLAFTLFTFFKV 484  human
P46896        372 FGFVAFFEIGPGPIPWFIVAelFSQGPRPAAFAVAGLSNWTSNFIVGMGFQYiaQLCGSYVFIIFTVLLVLFFIFTYFKV 451  chicken
NP_035530     373 FGFVAFFEVGPGPIPWFIVAelFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYveQLCGPYVFIIFTVLLVLFFIFTYFKV 452  African clawe...
XP_007910334  372 FGFVAFFEIGPGPIPWFIVAelFSQGPRPSAIAVAGLSNWTANFIVGMGFQYieMVCGPYVFIIFTVLLLIFFIFTYFKV 451  elephant shark
Q90592        417 FLFVIFFEVGPGPIPWFIVAelFSQGPRPAAIAVAGFCNWACNFIVGMCFQYiaDLCGPYVFVVFAVLLLVFFLFAYLKV 496  chicken
NP_001036186  383 FMFVSFFEIGPGPIPWFIVAeiFSQGPRPAAIALAGFCNWTCNFIVGMVFPYlvSLCGSYVFIVFAVLLFGFTLFIYFRV 462  zebrafish
Q8IRI6        376 LGFVVFFAVGPGSIPWMITAelFSQGPRPSAMAIAVLVNWMANFVVGIGFPSmkTALENYTFLPFSVFLAIFWIFTYKKV 455  fruit fly
Feature 1               
4ZW9_A        473 PETRGR 478  human
4PYP_A        453 PETKGR 458  human
P14672        469 PETRGR 474  human
P11168        485 PETKGK 490  human
P46896        452 PETKGR 457  chicken
NP_035530     453 PETKGR 458  African clawed frog
XP_007910334  452 PETKGR 457  elephant shark
Q90592        497 PETKGK 502  chicken
NP_001036186  463 PETKGK 468  zebrafish
Q8IRI6        456 PETKNK 461  fruit fly

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