Conserved Protein Domain Family
MFS_MT3072_like

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cd17475: MFS_MT3072_like 
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily
This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Statistics
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PSSM-Id: 341028
Aligned: 24 rows
Threshold Bit Score: 272.189
Created: 12-May-2017
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative
Feature 1:putative chemical substrate binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of MFS transporters with bound substrates, substrate analogs, and/or inhibitors
  • Comment:since MFS proteins facilitate the transport of many different substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides, the residues involved in substrate binding may not be strictly conserved among superfamily members
  • Comment:the substrate binding site or translocation pore has access to both sides of the membrane in an alternating fashion through a conformational change of the MFS transporter

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ##  ##  #                               #                                
P9WJW6     18 SLGVTASSFLFINGVAFLIPRLEnargTPLSHAGLLASMPSWGLVVTMFAWGYLLDHVGERmVMAVGSALTAAAAYAaas 97  Mycobacterium tube...
SDY91554   43 GFGAQAAFSVAFQGIPVAGPLMQtayqLTTGQLGLVLSFMSLGIAVSDVVWGIVSDRIGERkVLVAGMVGLTVVLGLisa 122 Amycolatopsis xyla...
SES78662   23 LVLAQIMVAVIGRSLGPLSVLIEedlsLTKAQVGLLPSALFLGQAISSIPTGFFADRFGSRpLLFIFTACLGISFFLmti 102 Salinibacillus kus...
OGD55951   73 AWISYMAVYMVRTSVPPLSPFIVeelsLSKTEVGLLISAGALGYSVFQLPAGWLIDRVGVKrMLAAGTFAAGAIIINmll 152 Candidatus Bathyar...
OGP74826   19 LWVSHTVYSLNYMTVGVLAPFIQpdlgLSAAQIGLLCSAIALGCMVIQIPSGVLSDRFGPKwVMALGLLFIGGAAISlss 98  Deltaproteobacteri...
OLB39639    1 MTAAFALSALSALAVAPLAPFLLeslrLSRAHVGFFLPAVYLGGVLMALPAGWLTDLLGVRrTLGLGQLLTGAMVALagl 80  Candidatus Rokubac...
KKM10077   22 VSFLVLAAAMSQFSYAPMSPFLIdyfhLTKTQMGVLASAVFLGVITTTFIAGWMVDVVGVRkMILVGPGLMALSSIGvsm 101 Clostridiales bact...
OLZ11683   24 ATLSQTGMTFVQQGVIVLGFFLAakyaLNFQQIGLITSAMSLGVMTSMVFMGILADKWGPKrLLFRATWIMALLAFGlrw 103 Sulfobacillus ther...
Q986D7     40 GVAANASFSATFSGIPATAVVLRqgyhLSNAELGLALGVLGLGVALSELPWGLLTDRWGDRrVLLIGLGATAAWLLAmam 119 Mesorhizobium loti
KFG95435   29 GVAANMSFSAAAAGIPTTAVWMRtayrLDNGALGLVLGALGFGVALSELPWGIAADRFGDRrVLLTGLVATAAMLALmvc 108 Burkholderia sp. MSh1
Feature 1                              ## ###  #                   #  ##  #                   
P9WJW6     98 vh--------sllwIGVFLFLGGMAAGGCNSAGGRLVSGWFppqqRGLAMGIRQTAQPLGIASGALVIPELAe--rGVHA 167 Mycobacterium tube...
SDY91554  123 flvpaggqiptialLSLGLLVAGALGGSVNGASGRAIMAWFskreRGFAISVRVTAVPVGGAIGAAALPFLAmn-yGFRG 201 Amycolatopsis xyla...
SES78662  103 qn--------vyglVLLIIVMGGIGYGGMHPTTNRGIIYWYsqnqRGTAMGIKQMGITFGSALSAILLLPLAet-yGWRI 173 Salinibacillus kus...
OGD55951  153 ag--------slpvAFTVLFLGGFGYGCFPAVATKALLQWFppneRGTAVGIQQTSINAAGIITAMTLPLIAsg-lSWRF 223 Candidatus Bathyar...
OGP74826   99 vh--------symgAFSLLVLLGMGIGCNQAPGTKAIVAWFpskgRATAMGFKQTGINMGAVLASILLPSIAlqfnNWRI 170 Deltaproteobacteri...
OLB39639   81 tg--------slpfMLCCLVVAGFGFSVANPATGRAIVEWFpareRGMAMGIKQTGLTIGGILGSLLLPPIAlr-lGWRD 151 Candidatus Rokubac...
KKM10077  102 ah--------aywvVFGWLFLLGVGNSVMMPLGNTAIFEWFrreqRGLAMGIKQSGMAAGPALGAALLPGVSla-fGWQR 172 Clostridiales bact...
OLZ11683  104 vq--------gfvlVLVCFFLLGMSLSAVPMSGSKAIFTAFqdrdRGMPMGIRQTGVPFGAALAAVILPVMVih-fGLPA 174 Sulfobacillus ther...
Q986D7    120 lvvptrsgvpdvmlLSASLLFTGLLGGSVNGSSGRAIMGWFreneRGFAMSIRQTAVPLGGGLGALVLPSLAla-fGFSA 198 Mesorhizobium loti
KFG95435  109 tivptshtvpplmhVVAAMCCVGLLGGSVNGSSGRAVMRWFgereRGLAMSIRQTAVPLGGGVGAALLPSLAsh-sGFAA 187 Burkholderia sp. MSh1
Feature 1                                                                  #  ##  ###  #      
P9WJW6    168 GLMFPAVVCTLAAVASVLGIVDPprksrtkase---------qelaspyrgsSILWRIHAASALLMMPQTVTVTFMLVWL 238 Mycobacterium tube...
SDY91554  202 VFVFLTVISLAATAAIYFWLDEPpvakaapkikgq-----krvstvpsplrvWNVWRVAIASGLLTCPQFVVLTFAGIYL 276 Amycolatopsis xyla...
SES78662  174 VVSIACFGLIAAGVIAFLFYRDPvevksvekkkdts---entftaikammrhKPLLLISISAMGINGSQMTLNTYLVLFT 250 Salinibacillus kus...
OGD55951  224 GFVAVGLLSIVASVISLRFYKEPpgfnletgseatri--riewttirevilnRNIQLVSISCIGYMAVDYSLVTYLIIYL 301 Candidatus Bathyar...
OGP74826  171 SFRVAGLASVFSAILLILFYKERqtpsldsfrp---------lfskkgalfgRDFLLVCFAGVFLMASQYSFSTYFLLYA 241 Deltaproteobacteri...
OLB39639  152 ALVVAGLLSIASAVAVMVSYRPPsliavrapverp------rfselgvvmrrRGVQVVFAAGFLLSLAQASVLAYLALYA 225 Candidatus Rokubac...
KKM10077  173 GYQLAGLLLAGCTLLSYLFYRDPenpstvglkqsv-----pslaaikeiffnPDVWLVGIFGLSMGGAQVAFTTFSMPYF 247 Clostridiales bact...
OLZ11683  175 VYLLFMAELVLFNGIFSALIPDIkpavret---------------vkestsfRPLKWPAVVSFLMVAGQYFLVTFTLEYL 239 Sulfobacillus ther...
Q986D7    199 VFTLLAGASALSALFAWRWLHEPpaaahvaasa----------aagpaplrnIEVWRIATAIGLLCFPQVAVLTFASVFL 268 Mesorhizobium loti
KFG95435  188 VFGALMLMCAGSAVLTWRWLREPpaepadaplathrpatppparnarnplasGPVWRIVFGIGLLCAPQFAVLTFATVFL 267 Burkholderia sp. MSh1
Feature 1                          #   #                                                      
P9WJW6    239 inhhgwsvaqagvLVTISQLLGALGRVAVGRWSDHvgsRMRPVRLIAAAAAATLFLLAAvdnegs------------ryd 306 Mycobacterium tube...
SDY91554  277 htakgvgigaiagLLVAVQVLGAVSRVWGGRWTDRrdgRLRRTVIKWMSWITAIGFVGVavasdap----------apvs 346 Amycolatopsis xyla...
SES78662  251 hqqlgvnlvlagfLLVISEVGGSLGRIGWGLISDRvfgGERLKVMGIIVIITLCASTIVaflpvgt---------pywll 321 Salinibacillus kus...
OGD55951  302 keavgvavtlagfYLALTNIGGLLGKLFFGLMSDRvfeGSRKKPLLLAGCIMLAVSVIVqaispvt---------pswai 372 Candidatus Bathyar...
OGP74826  242 tkildlpithsgtLLALAFGAGAMARIGWGLVSDYlfgGRRKSVITLIGIIGAMTAFGFillkfhp---------lawli 312 Deltaproteobacteri...
OLB39639  226 retfdvspvaagqLLALAQLGGTLARLGWGFASDHffrSRRRPGVVITALTGALAYVVFslgavvp----------svla 295 Candidatus Rokubac...
KKM10077  248 devlaipvvtggaLLALTQLSGAVGRPVFGMISDRvfsGRRKGIMCMTAFAAVGFLVIMsflsrgv---------hpgll 318 Clostridiales bact...
OLZ11683  240 hddrhltlgqsgwVLAMAQIGGGLGRILFGRMSDRl-qGNRPRVISFTGLLASAMIAVIlllpshv---------pygvi 309 Sulfobacillus ther...
Q986D7    269 hdfvglgtvaisaSLAAVQIGAMVMRVWSGRFTDRh--GNRRQFLRSCSALSGLAFSVLwlmvlagsavpggqsfliavl 346 Mesorhizobium loti
KFG95435  268 hdfgrlglagistAMVVLQLGAMAMRVWSGRHTDRh--GNRRAYLRGSVYVATGSFALLaaatagsph------vplaai 339 Burkholderia sp. MSh1
Feature 1              ##   #   #               #  ##  ##  #                                  
P9WJW6    307 vlLMIAISVIAVLDNGLEAAAITEyagpywsGRALGIQNTTQRLMAAAGPPLFGsli-ttAAYPTAWALCGVFPLAAVPL 385 Mycobacterium tube...
SDY91554  347 vsLLCVSGVFACGWHGIAYAEIAEiagaersGTALGLENTMVFAGAFITPVLIPv----vLDFSGSWAVTMVLIGAVPAV 422 Amycolatopsis xyla...
SES78662  322 vpLFFLFGLAVSGFNGIWMNLASElvpkeqaGLSSGFSISFGSLGVILLPPIFGliidqtHSYTFGWLLIAFIMVLVMLV 401 Salinibacillus kus...
OGD55951  373 alIFAVFGFSAIGWGGQNLILVSEsvkkdvaGLAMGYSLMILLIGNIVGPPVFGyivdvtGSYSPAWWFLTACSVAAIAI 452 Candidatus Bathyar...
OGP74826  313 ysLTILFGLSGIGWNAIYLTMVGEfageslaGIATSLSFLISNLGPLIGPPLFGyfidltGGYALSWFFVAGCMVVVALL 392 Deltaproteobacteri...
OLB39639  296 apLAFLAGAGAFGWVGLYFALVAEvggpryaGLLTGVAVVFTWSGVLVGPLVFGavlqasGDYAWSWRLLSVIVVVTALA 375 Candidatus Rokubac...
KKM10077  319 vaLMILMGLTIMGWAGPYFTLIVEvagerniGLVSSMAVTMNLIGIMSGPPLFGlivdstSSYRWAFRFFALWLGIASLI 398 Clostridiales bact...
OLZ11683  310 mgVWFLTGMGTIGWNALSLTWAAEsvpsqqaGFAMGLVGTIIFLGSAVFPPLLGslidwtKHFTAAWATLMAILLLASAL 389 Sulfobacillus ther...
Q986D7    347 pfVLIVAGISVSAWHGVAYTELATlagaghvGTALSLANTFVFVGFFLVPVAIPgll-hlWSWPGVWLSASLCALIAWPI 425 Mesorhizobium loti
KFG95435  340 vaILVFAGICVSAWHGVAYTELATlaganhaGTALGMANTIVYLGLFATPLAIPlll-ahASWSVVWLAAAACAGATLPL 418 Burkholderia sp. MSh1
Feature 1       
P9WJW6    386 VP 387 Mycobacterium tuberculosis CDC1551
SDY91554  423 IA 424 Amycolatopsis xylanica
SES78662  402 LK 403 Salinibacillus kushneri
OGD55951  453 MS 454 Candidatus Bathyarchaeota archaeon RBG_13_52_12
OGP74826  393 TK 394 Deltaproteobacteria bacterium RBG_16_50_11
OLB39639  376 VA 377 Candidatus Rokubacteria bacterium 13_2_20CM_2_64_8
KKM10077  399 FL 400 Clostridiales bacterium PH28_bin88
OLZ11683  390 AR 391 Sulfobacillus thermosulfidooxidans
Q986D7    426 FL 427 Mesorhizobium loti
KFG95435  419 FP 420 Burkholderia sp. MSh1

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