2R4S,4L6R,4JKV,4OR2,1UAZ


Conserved Protein Domain Family
7tm_GPCRs

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cd14964: 7tm_GPCRs 
Click on image for an interactive view with Cn3D
seven-transmembrane G protein-coupled receptor superfamily
This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.
Statistics
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PSSM-Id: 341315
View PSSM: cd14964
Aligned: 14 rows
Threshold Bit Score: 86.344
Threshold Setting Gi: 30750138
Created: 9-May-2005
Updated: 26-Jul-2017
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:TM helix 1 [structural motif]
Evidence:
  • Comment:All members of this receptor family contain a seven-transmembrane helix domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     #########################                                                       
2R4S_A     13 MGIVMSLIVLAIVFGNVLVITAIAKFErlq---tvtNYFITSLACADLVMGLAvvPFGAahilmkmw------------- 76  human
4L6R_A    125 FQVMYTVGYSLSLGALLLALAILGGLSklh---ctrNAIHANLFASFVLKASSv-LVIDgllrtrysqkigddlsvstwl 200
4JKV_A    150 MHSYIAAFGAVTGLCTLFTLATFVADWrnsn--rypAVILFYVNACFFVGSIGw-LAQFmdgarreivcradgtmrlgep 226
4OR2_A    121 ESIIAIAFSCLGILVTLFVTLIFVLYRdtpvvksssRELCYIILAGIFLGYVCp-FTLIakpt----------------- 182
1UAZ_A     15 ETLWLGIGTLLMLIGTFYFIVKGWGVTdk-----eaREYYSITILVPGIASAAy-LSMFfgigltevq-----------v 77  Halobacterium sp.
Q7Z5H5      7 AVGMILSQTVVGVLGSFSVLLHYLSFYctgcrlrstDLIVKHLIVANFLALRCk-GVPQtmaafgvr------------- 72  human
Q86SP6     36 LFCLTCLMTFAALVGSIYSLISLLKMQnrt----vvSMLVASWSVDDLMSVLSv-TIFMflqwpnev------------- 97  human
Q9NYW3      9 LLFLAVGEFSVGILGNAFIGLVNCMDWvkkrkiasiDLILTSLAISRICLLCVi-LLDCfilvlypd------------- 74  human
Q9TX43     10 TYSILVIADFSSIFGCLLVLIAFKKLKl-------lRNHITRVIACFCVSSLLk-DIIStgltlslgpq---------ne 72  Dictyostelium disc...
Q6NV75     10 SAVGWLVCGGLSLLANAWGILSVGAKQkkw---kplEFLLCTLAATHMLNVAV--PIATysvvqlrrqr---------pd 75  human
Feature 1                                                                                     
2R4S_A     77 -tfgnfwcEFWTSIDVLCVta-sIETLCVIAVdryfaitspfk-----yqslltknkarVIILMVWIVSGLTSFLPiqmh 149 human
4L6R_A    201 sdgavagcRVAAVFMQYGIva-nYCWLLVEGLylhnllgla---------tlpersffsLYLGIGWGAPMLFVVPWavvk 270
4JKV_A    227 tsnetlscVIIFVIVYYALma-gVVWFVVLTYawhtsfkalgt------tyqplsgktsYFHLLTWSLPFVLTVAIlava 299
4OR2_A    183 ----ttscYLQRLLVGLSSam-cYSALVTKTNriarilagskkkictrkprfmsawaqvIIASILISVQLTLVVTLiime 257
1UAZ_A     78 gsemldiyYARYADWLFTTpl-lLLDLALLAKvd------------------------rVSIGTLVGVDALMIVTGlvga 132 Halobacterium sp.
Q7Z5H5     73 yflnalgcKLVFYLHRVGRgv-sIGTTCLLSVfqvitvssrksrw--aklkekapkhvgFSVLLCWIVCMLVNIIFpmyv 149 human
Q86SP6     98 pgyfqflcTTSALMYLCQGlssnLKATLLVSYnfytmhrgvgs-----qtasrrsgqvlGVVLTVWAASLLLSALPlcgw 172 human
Q9NYW3     75 vyatgkemRIIDFFWTLTNhl-sIWFATCLSIyyffkignffhpl-flwmkwridrvisWILLGCVVLSVFISLPAtenl 152 human
Q9TX43     73 agstsfqcYLYAITITYGSla-cWLWTLCLAFsiynlivkr---------epepekyekFYHGVCWTIPLICVIVMlakk 142 Dictyostelium disc...
Q6NV75     76 fewneglcKVFVSTFYTLTla-tCFSVTSLSYhrmwmvcwpvn-----yrlsnakkqavHTVMGIWMVSFILSALPavgw 149 human
Feature 1                                                                                     
2R4S_A    150 wyrathqeai------ncyanetccdfftnQAYAIASSIVSFYVPLVIMVFVYSrvfqeakrqlqkidksegrfhvqn-- 221 human
4L6R_A    271 clfen-----------------vqcwtsndNMGFWWILRFPVFLAILINFFIFVrivqllvaklr--------------- 318
4JKV_A    300 qvdgdsv-------------sgicfvgyknYRYRAGFVLAPIGLVLIVGGYFLIrgvmtlfsiksnhpg----------- 355
4OR2_A    258 ppmpilsy----------psikevylicntSNLGVVAPLGYNGLLIMSCTYYAFktrn---------------------- 305
1UAZ_A    133 ls-----------------------htplaRYTWWLFSTICMIVVLYFLATSLRaaak---------------------- 167 Halobacterium sp.
Q7Z5H5    150 tgkwnytnitvnedlgycsgggnnkiaqtlRAMLLSFPDVLCLGLMLWVSSSMVcilhrhkqrvqhi------------- 216 human
Q86SP6    173 gafvrtpwgc------lvdcsssyvlflsiVYALAFGLLVGLSVPLTHRLLCSEepprlhsnyqeisrgasipgtpptag 246 human
Q9NYW3    153 nadfrfcvkak----rktnltwscrvnktqHASTKLFLNLATLLPFCVCLMSFFllilslrrhirr-------------- 214 human
Q9TX43    143 tiep-------------------vgnwcwiSEKYVGYRFGLFYGPFFAIWIISAvlvgltsrytysv------------- 190 Dictyostelium disc...
Q6NV75    150 hdtserf------------ythgcrfivaeIGLGFGVCFLLLVGGSVAMGVICTaialfqtlavqvgrqadrraftvp-- 215 human
Feature 1                                                                                     
2R4S_A    222 -----------------------------------lsqveqdgrtghglrrsskfclkeHKALKTLGIIMGTFTLCWLPF 266 human
4L6R_A    319 -------------------------------------------------arqmhhtdykFRLAKSTLTLIPLLGVHEVVF 349
4JKV_A    356 ---------------------------------------------llsekaaskinetmLRLGIFGFLAFGFVLITFSCH 390
4OR2_A    306 -------------------------------------------------------vpanFNEAKYIAFTMYTTCIIWLAF 330
1UAZ_A    168 --------------------------------------------------------ergPEVASTFNTLTALVLVLWTAY 191 Halobacterium sp.
Q7Z5H5    217 -----------------------------------------------drsdlspraspeNRATQSILILVSTFVSSYTLS 249 human
Q86SP6    247 rvvslspedapgpslrrsggcspssdtvfgpgapaaagaeacrrenrgtlygtrsftvsVAQKRFALILALTKVVLWLPM 326 human
Q9NYW3    215 -----------------------------------------------mqlsatgcrdpsTEAHVRALKAVISFLLLFIAY 247 human
Q9TX43    191 -----------------------------------------------irnsvsdnkdkhMTYQFKLINYIIVFLLCWVFA 223 Dictyostelium disc...
Q6NV75    216 ------------------------------------tivvedaqgkrrssidgsepaktSLQTTGLVTTIVFIYDCLMGF 259 human
Feature 1                                                                       
2R4S_A    267 FIVNIvhviq-------------------------dnlirKEVYILLNWIGYVNSGFNPLIYCRSP 307 human
4L6R_A    350 AFVTDehaq---------------------------gtlrSAKLFFDLFLSSFQGLLVAVLYCFLN 388
4JKV_A    391 FYDFFnqaewersfrdyvlcqanvtiglptkqpipdceikNRPSLLVEKINLFAMFGTGIAMSTWV 456
4OR2_A    331 VPIYFg---------------------------------sNYKIITTCFAVSLSVTVALGCMFTPK 363
1UAZ_A    192 PILWIigtega------------------------gvvglGIETLLFMVLDVTAKVGFGFILLRSR 233 Halobacterium sp.
Q7Z5H5    250 CLFQVcmall--------------------------dnpnSLLVNTSALMSVCFPTLSPFVLMSCD 289 human
Q86SP6    327 MMHMVvqnvv--------------------------gfqsLPLETFSFLLTLLATTVTPVFVLSKR 366 human
Q9NYW3    248 YLSFLiatssy------------------------fmpetELAVIFGESIALIYPSSHSFILILGN 289 human
Q9TX43    224 IVNRIlngl---------------------------gyypTLPNILHTYFSVSHGFFASVTFIYNN 262 Dictyostelium discoideum AX4
Q6NV75    260 PVLVVsfsslr------------------------adasaPWMALCVLWCSVAQALLLPVFLWACD 301 human

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