Conserved Protein Domain Family
7tmA_CXCR3

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cd15180: 7tmA_CXCR3 
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors
CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.
Statistics
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PSSM-Id: 341335
Aligned: 8 rows
Threshold Bit Score: 356.308
Threshold Setting Gi: 348075966
Created: 9-Dec-2008
Updated: 17-Aug-2020
Structure
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Aligned Rows:
  next features
Feature 1:putative chemokine binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of chemokine receptors with bound ligands (chemokines, peptides, or chemical antagonists/agonists)
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #                                                #  #                 #  #
P49682        54 AFLPALYSLLFLLGLLGNGAVAAVLLSRRTalssTDTFLLHLAVADTLLVLTLPLWAVDAav--qWVFGsglCKVAGALF 131 human
CAQ13803      49 IFKPILYSLAAVVGLLGNGLVLIVLWKKRAglnvTDIFILHLSLADILLLLTLPFWAVEAvk--eWIFGtplCKLTGAMF 126 zebrafish
AAH73571      70 RFLPAFYSIVFLLGMLGNVLVLVVLLQNRWrlqsTDIFLLHLALADILLVVTLPFWATQAvs--gWIFGnvlCKMVASIF 147 African clawed ...
CAF98051      30 TFILVLYLLAFVVGVVGNGLLLLVLVQNRRtwsvTDTFILHLAMADVLLLVTLPTWAAQAaqdegWTFGtplCKITGAVF 109 Tetraodon nigro...
CAQ13804      38 VFIPLLYSLGILLGLLGHGLVLAVLWHKWLncsvMDIFIFHLSLIDSLLLLTMPLWAVDAvk--gWIMGsglCKLAGVLF 115 zebrafish
EMP41763      34 VFLPVLYSLLFPLGLCGNCMVMAVLLQCKRplagTDVFILNLALADVLLVVTLPFWAVQAvh--gWVFStgtCKLVGSIF 111 green seaturtle
AEP60129      35 VLVTVLYSAVLVVGLLGNVLLLALLAQKRRswtiSDTFVLHLAAADLLLLVALPLRAAQAahgggWYSGvalCKISGAVF 114 turbot
XP_005999214  55 VFLPVFYSLIFLVGVIGNTMVMSVLLKYKRvlaiTDTYILHLAVADILMVATLPFWAVEAvh--kWIFGtaaCKIIGSVF 132 coelacanth
Feature 1        #                                                                       ######  
P49682       132 NINFYAGALLLACISFDRYLNIVHatqLYRRGppARVTLTCLAVWGLCLLFALPDFIFlsahhd-erlnaTHCQYNFPqv 210 human
CAQ13803     127 RINFYCGIYMLSCISLDRYLSIVHavqMYSRKkpMAVHCCCMIVWFFCFLLSIPDWILlgankdsrrqdrTECVNSEAls 206 zebrafish
AAH73571     148 KINFYACTFLLVCISCDRYLSIVYavqLYKKHrtHLVHWSCLLVWCLCIGLSIPDMVYyrvtye-pranvTDCQPDFGhl 226 African clawed ...
CAF98051     110 MVNFYCGIFLLGCISFDRYLSIVHathMYSHRkpWAIRISCMAAWLFSLLLSITDLVFleavsn-drlnrTMCVRNYLmf 188 Tetraodon nigro...
CAQ13804     116 KMNFYCSMLMLAFISVDCYLSIVHgvqKLSRKkpMVVHGCCLIIWLVCLLLSIPEWIFlksisdstdqvkDECIYFYPdd 195 zebrafish
EMP41763     112 KINFYSSIFFLVCISFDRYLSIVHavhMYKRNksHLMVATCLVVWGVCILLTMPDFLYlevkkd-yrlntTLCSHNFSin 190 green seaturtle
AEP60129     115 NINFYCGIFLLACISVDCCLSIVHatkLYSHKkpGFAHLSCLLVWFISLLLSIPDFIFlttekd-aaqmkTVCVHSYPqs 193 turbot
XP_005999214 133 KINFYSGIFLLGCISFDRYLSIVHavqMYKKRksYSVHLSCFVVWAFCFLLTIPDMIYlestyv-pqskvIQCIHNFNts 211 coelacanth
Feature 1                          #  ##                                                         
P49682       211 -----------------gRTALRVLQLVAGFLLPLLVMAYCYAHILAVLlvs---rgQRRLRAMRLVVVVVVAFALCWTP 270 human
CAQ13803     207 d---------------fwVLVNRLIYHFLGFIIPAIMMVFCYTSILLRLllg--skcMQKKRAIHVIVALVLAFFISWTP 269 zebrafish
AAH73571     227 ds-------------ktwKISLTFLYHIVGFLIPLCFMVYCYTHIIHSLcqt---hgFKKQKALRVVIAVVVIFFLCWTP 290 African clawed ...
CAF98051     189 tkqseeftagvnstqvnwQLSSRLIYHIVGFLLPSAVMIFCYTCILRRLrcs--sqgLQKQRAIRVIIAVVAVFFLCWTP 266 Tetraodon nigro...
CAQ13804     196 -----------------sWHRSSRFPHHVIFGVGTLVLLFCCTSIMLKLqresmcqqKKIGRKTAIIAVLVLVFLICWTP 258 zebrafish
EMP41763     191 ts-------------lywKMALRICYHLLGFFLPLAAMLYCYTCIIHTLlrs---qgFHKHKAMRVILTVVVVFFLCWTP 254 green seaturtle
AEP60129     194 a--------------tdwWLLSHLPHLILGFLLPAATLIICCFLILLRLqqr--skkLQKERAIMVILPLVVVFFLCWMP 257 turbot
XP_005999214 212 sa-------------rywRNALRFNYHIIGFIIPFCIMVYCYMMIFKTLsas---qgFQKQKALRVVVAVVVAFFLCWAP 275 coelacanth
Feature 1        #      #  #              #   #  ##  #                         
P49682       271 YHLVVLVDILMDlgala---rncgrESRVDVAKSVTSGLGYMHCCLNPLLYAFVGvkFRERM 329 human
CAQ13803     270 YNIALMADTIHTnrtdnn-qtscktRTTLDVAITATSTLAYMHCCVNPILYAFVGvkFRQHL 330 zebrafish
AAH73571     291 YNIVALLDTMNIlnvlp---dncttDSNIDIALSVTSGLCYFHSCLNPLLYAFVGakFKMKL 349 African clawed frog
CAF98051     267 YNIVLLVDTFYSpsgsd----kcgmHTSMEKALTVTSSVGYLHCSLNPILYAFVGvkFRRQL 324 Tetraodon nigroviridis
CAQ13804     259 YSIAFIVNTGARpvhidpltgesecEWRQWTASKITAIFGLLHCTINPVIYFCFSkeFRRRS 320 zebrafish
EMP41763     255 YHLALLANTLIDlqvvg---rdcgkEASLDITMSVTASLGYFHCCLNPLLYAFIGikFRNKF 313 green seaturtle
AEP60129     258 YNITLIVDTSRGrsk-------qpqEGSLKTALMVTSALGCVHACLRPLLYLCLCgnFRKLT 312 turbot
XP_005999214 276 YNLTLGVDTLIElells---rdcdmEFRLDISKSVTSSLGYFHCCLNPFLYAFIGvkFRNKF 334 coelacanth

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