3COJ,1L0B,3K0H,2ING,1JNX,4Y18,4JLU


Conserved Protein Domain Family
BRCT_BRCA1_rpt2

?
cd17721: BRCT_BRCA1_rpt2 
second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
BRCA1, also termed RING finger protein 53 (RNF53), is a RING finger protein encoded by BRCA1, a tumor suppressor gene that regulates all DNA double-strand break (DSB) repair pathways. BRCA1 is frequently mutated in patients with hereditary breast and ovarian cancer (HBOC). Its mutation is also associated with an increased risk of pancreatic, stomach, laryngeal, fallopian tube, and prostate cancer. It plays an important role in the DNA damage response signaling, and has been implicated in various cellular processes such as cell cycle regulation, transcriptional regulation, chromatin remodeling, DNA DSBs, and apoptosis. BRCA1 contains an N-terminal C3HC4-type RING-HC finger, and two BRCT repeats at the C-terminus. The family corresponds to the second BRCT domain.
Statistics
?
PSSM-Id: 349353
Aligned: 21 rows
Threshold Bit Score: 123.914
Threshold Setting Gi: 607367936
Created: 14-Apr-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:ACC1 interaction site [polypeptide binding site]
Evidence:
  • Structure:3COJ: Homo sapiens BRCA1 in complex with a phosphorylated peptide from human acetyl-COA carboxylase 1, contacts at 4A.
    View structure with Cn3D
  • Comment:BRCA1 regulates lipid biosynthesis through its inhibition of ACC1 activity

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                         ##                                                              
3COJ_X        134 RKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKElssftlgtGVHPIVVVQPdawte--------dngfHAIGQMCE 205  human
NP_001084248 1482 GLLLIDFEICFFGSFTDMTLDDLEWMVSECGATVVKKlqffkkkhNVTSLVIVQPdaste--------vrdyTEIRKKHK 1553 African clawe...
AAR89523     1171 NLLMKGYSICFQGPFTDMTTAEMELMVEXCGATVVQDpllldgkrTSHQLIVVQSgs--------------eSSRSVSGK 1236 spotted green...
ABL86143     2524 PGFMAKFDLCCIGPFTGLNKDQLVGLCEMCGASTVQHpslfpynpGRKAFIVVEPnldt---------drnyQGLQRKFR 2594 purple sea ur...
XP_002599481 2506 KLLLCDYEICIYGKFTALTRDDLQFMVELCGGTVVKEphm--fphDKKPLIVSQIdanql-------teedyNVFYRRYG 2576 Florida lancelet
XP_006821068 2127 RLLLHNYEISCIGSFSGLTKDQLYWLLELCGAEKVNNpsmfsynpNKRTIIIMQPdandsa------ksfnyNNFYKKYT 2200 Saccoglossus ...
XP_013094391 1199 NLLFNNFCFACIGNSDEMSKGDLCDILQACGALIVDDpialaaqpTKYKLIIRCSdgdnvpt---pveldmfNGLYKHMR 1275 Biomphalaria ...
XP_013419456 1468 QLLLRGYEICCAGGYTGLAIDDLKNLVELCGGATVQDpsmfsfqpGSKRVVLIQPsehgv-------drnkcDKIYKKYS 1540 Lingula anatina
OWF51886     2420 QPLFDGFHFFCLGTSDSLTTENLQELIERCGGTVVDHpsaf-ppdTKLNLAITCIdlededdlpspedtrsfNKLHKRFG 2498 Yesso scallop
EZA62063     1544 KGLFEDFTFLCVGPYINVTLHQYQDLLLATGATVVDSlegl-akaRGLRGIVIQDnthd---------dktiKHWSRATK 1613 clonal raider...
Feature 1              ##   #           ##  
3COJ_X        206 APVVTREWVLDSVALYQCQELDTYLI 231  human
NP_001084248 1554 ALVVTREWLMDSVATYRLQKFDAYLA 1579 African clawed frog
AAR89523     1237 ATVVTRGWLLDSVATYTIQNLKNYRA 1262 spotted green pufferfish
ABL86143     2595 VPVISREWVLDSIALYKSQPITDYLL 2620 purple sea urchin
XP_002599481 2577 VLSVTRDWILDSVSSYQIQPIERYLM 2602 Florida lancelet
XP_006821068 2201 ALVVSREWILDSIAKYTVQPLSEYLL 2226 Saccoglossus kowalevskii
XP_013094391 1276 LVTVMREWVLDSLGSYKIIPLADYVL 1301 Biomphalaria glabrata
XP_013419456 1541 AMTLNREWLLDSVALYRVQHWGEYVL 1566 Lingula anatina
OWF51886     2499 LLTVSREWVLDSLTVYTVQPLKEYVL 2524 Yesso scallop
EZA62063     1614 AAPIIVDWVVECISRYKLFELAPYIQ 1639 clonal raider ant

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap