1JNX,1L0B,1T2U,3COJ,3K15,4Y18


Conserved Protein Domain Family
BRCT_BRCA1_rpt1

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cd17735: BRCT_BRCA1_rpt1 
first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
BRCA1, also termed RING finger protein 53 (RNF53), is a RING finger protein encoded by BRCA1, a tumor suppressor gene that regulates all DNA double-strand break (DSB) repair pathways. BRCA1 is frequently mutated in patients with hereditary breast and ovarian cancer (HBOC). Its mutation is also associated with an increased risk of pancreatic, stomach, laryngeal, fallopian tube, and prostate cancer. It plays an important role in the DNA damage response signaling, and has been implicated in various cellular processes such as cell cycle regulation, transcriptional regulation, chromatin remodeling, DNA DSBs, and apoptosis. BRCA1 contains an N-terminal C3HC4-type RING-HC finger, and two BRCT (BRCA1 C-terminus domain) repeats at the C-terminus. The family corresponds to the first BRCT domain.
Statistics
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PSSM-Id: 349367
Aligned: 15 rows
Threshold Bit Score: 182.161
Threshold Setting Gi: 119655545
Created: 4-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ACC1 interaction site [polypeptide binding site]
Evidence:
  • Structure:3COJ: Homo sapiens BRCA1 in complex with a phosphorylated peptide from human acetyl-COA carboxylase 1, contacts at 4A.
    View structure with Cn3D
  • Comment:BRCA1 regulates lipid biosynthesis through its inhibition of ACC1 activity

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ### #                                       ##### #                         
1JNX_X          5 MSMVVSGLTpeEFMLVYKFARKhHITLTNLiteeTTHVVMKTDaEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKML 84   human
1L0B_A          8 ISMVVSGLTpkEVMIVQKFAEKyRLALTDViteeTTHVIIKTDaEFVCERTLKYFLGIAGGKWIVSYSWVIKSIQERKLL 87   Norway rat
3COJ_X         26 MSMVVSGLTpeEFMLVYKFARKhHITLTNLiteeTTHVVMKTDaEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKML 105  human
4Y18_A         15 MSMVVSGLTpeEFMLVYKFARKhHITLTNLiteeTTHVVMKTDaEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKML 94   human
AAR89523     1062 MLLVTSGLGpsQQITVKKFAKRiGATVVSQvtpeVTHVVMHTDeQLVCERTLKYFLGIAGRKWVVSFQWISECIKQKKLL 1141 spotted green...
NP_989500    1541 MSIVASGLNqsEHLMVQKFARKtQSTFSNHitdgTTHVIMKTDeELVCERTLKYFLGIAGRKWVVSYQWIIQSFKEGRIL 1620 chicken
NP_001084248 1374 LSFVASGLNqcEMALVQRFSKTtQSILSSRitdsTTHVIMKTDaELVCERTLKYFQGIASRKWVVSYEWVVQSFREGQIL 1453 African clawe...
XP_002599481 2399 MTFVTTGLSreETRAVHELAKKtGSQVKQSfdnsTTHVITRTDvDLFCSRTLKFFLGIAGRKWIVSFQWIAACLEEGKHV 2478 Florida lancelet
XP_006821068 2019 FSLVATGLTrqELKNVEYFAMEtGSKVEARfslnTTHVIVKTDvELVCERTLKYFFGIAARKWVVSYRWIQACTEAGKVV 2098 Saccoglossus ...
XP_007908385 1737 MSFVASGLDkhEILLVQRFAEKtGGAITSQflpsTTHVVMRTGtSLVCERTLKYFLGIAGRRWVISYQWILECFKEGRII 1816 elephant shark
Feature 1                   #      
1JNX_X         85 NEhdfeVRGDVVNGRNH 101  human
1L0B_A         88 SVhefeVKGDVVTGSNH 104  Norway rat
3COJ_X        106 NEhdfeVRGDVVNGRNH 122  human
4Y18_A         95 NEhdfeVRGDVVNGRNH 111  human
AAR89523     1142 NEtlfeVRGDVVNGFDH 1158 spotted green pufferfish
NP_989500    1621 DEehfeVKGDVINGRNH 1637 chicken
NP_001084248 1454 DEydfeVKGDVINGRNH 1470 African clawed frog
XP_002599481 2479 PEdpyeVRGDLVHGCHG 2495 Florida lancelet
XP_006821068 2099 PEdlyeVRGDVINGRNH 2115 Saccoglossus kowalevskii
XP_007908385 1817 EEsefeVRGDVINGRNH 1833 elephant shark

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