3VX3,2PH1,3KB1


Conserved Protein Domain Family
Mrp_NBP35

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cd02037: Mrp_NBP35 
Click on image for an interactive view with Cn3D
Mrp/NBP35 ATP-binding protein family
Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.
Statistics
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PSSM-Id: 349757
View PSSM: cd02037
Aligned: 70 rows
Threshold Bit Score: 187.709
Threshold Setting Gi: 323477044
Created: 15-Dec-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitedimer interface
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ########                                                                
3VX3_A        20 RIIPVVSGKGGVGKSLVSTTLALVLAekgyrVGLLDLDfHGASDHVILGfepkef------------------------- 74  Thermococcus ko...
ADX82282      21 KVIAVMSSKGGVGKSVVSALLSLSLVp---sATLIDLDiHSMGIAKLFGvenrsl------------------------- 72  Sulfolobus isla...
CAD26029      50 AVIAVMSGKGGVGKSTVTRNIAELMSsrgiaTCILDLDlSGPSIPRLTGtdgqlm------------------------- 104 Encephalitozoon...
XP_001314064  34 RLILTIGNKGGVGKSMVTVNTALALAktgnkVGIFDANiYSPDIPRLTGttnwlls------------------------ 89  Trichomonas vag...
XP_001330320  33 RIVVTVGAKGGVGKSTVAVNTALALAdidntAGVLDLDlFAPSVPQLCNtvtnnlq------------------------ 88  Trichomonas vag...
CAD90253     177 NIIAVSSCKGGVGKSTVAVNLAYTLAgmgarVGIFDADvYGPSLPTMVNpesrile------------------------ 232 thale cress
XP_002259292 125 NVIVVYSCKGGVGKSFFSVNLSFYLKkkgatVGLLDADiNGPSLPTLLPighsyakfksaprrsskifyegetgkrescv 204 Plasmodium know...
XP_002139379 239 YIIAVSSCKGGVGKSTLAVNFTYTLSmqgakVGLVDCDiYGPSLEQLVPvnytsmhyispsssnehvlnklikds----- 313 Cryptosporidium...
XP_955520      7 NVIAIHSCKGGVGKSTVSVSLALSFAskgisVGICDLDiCGPSLAQLFSldrgsvkwnhtksngynsdik---------- 76  Theileria annul...
XP_002787044  32 YVIVVHSCKGGVGKSTVAFNLSVALAnsgldVGLVDADvMGPSLPAFIKpeeghlyfs---------------------- 89  Perkinsus marin...
Feature 1                                                                                        
3VX3_A        75 --------------------------------------peedrgVVPPTvh-gIKFMTIayyte------drptPLRGKe 109 Thermococcus ko...
ADX82282      73 --------------------------------------evskegIVPIKig-nVNLISLagivr------dryvILPGRn 107 Sulfolobus isla...
CAD26029     105 --------------------------------------cetngrLQPVEvhglLKAVSAgylqdp----ceegvVFSSTl 142 Encephalitozoon...
XP_001314064  90 --------------------------------------pdkqqnYLPITtg-gIQQVSVanvig-----kkdsiLWKNYv 125 Trichomonas vag...
XP_001330320  89 --------------------------------------lskeknFLPISay-gIETISVgngte-----rdqalLWNSQf 124 Trichomonas vag...
CAD90253     233 -------------------------------------mnpekktIIPTEym-gVKLVSFgfag-------qgraIMRGPm 267 thale cress
XP_002259292 205 eelteegvnhsggedgedevddpkrdkedrgdvhqydrlledplIEPLLyr-gVKLMSYayiknq---knlgfaSFRGPi 280 Plasmodium know...
XP_002139379 314 ------------------kcgiarssiqgnefinlndkvvetegIVPVFfe-gVALMSYsylsnslnkkrrvsnAFRGPi 374 Cryptosporidium...
XP_955520     77 ------------------------pvnltysdtsdlsqnknfmlLEPKEvq-gIKIMSSefllpl---nysgysAYRGPi 128 Theileria annul...
XP_002787044  90 -----------------------------------knekwaqpvKYPTArg-sLCCQSFgwldvnk--askqgaGLSAQs 131 Perkinsus marin...
Feature 1                                                           # #                        ##
3VX3_A       110 isdALIELLtITRWDeLDYLVIDMPPGLGDqLLDVLRfl-krGEFLVVATPSKLslNVVRKLIELLKeeGHKVIGVVENM 188 Thermococcus ko...
ADX82282     108 qsnVMKELIaYSIIN-SDYVVFDLPPGLGDeVLVLEElt--dFKPVAVTTPSKIaiKVVKNLIDYLNe-RGKKSLIVVNM 183 Sulfolobus isla...
CAD26029     143 ktsAMKKLLkWCSYEgTDVLLLDTPPNVTDeHLGMVNfi-rpRFGIVVTTPQKFslQDVARQVDFCRkaRIEVLGIIENM 221 Encephalitozoon...
XP_001314064 126 g-aILGDFLkKAIWQdVDYLLVDTPPGTGDiHMALSTlf-kaDGAIVVATPDALsfIDTCRCIDMLNrmPIPIVGIVENK 203 Trichomonas vag...
XP_001330320 125 ipkLVEQLSkKSEWSnLDYLIVDVPSGSIEiLSALNDhv-hiDGAIVVTGCDQLsqTSTLRTIDALHklKIPVSGIVKNF 203 Trichomonas vag...
CAD90253     268 vsgVINQLLtTTEWGeLDYLVIDMPPGTGDiQLTLCQva-plTAAVIVTTPQKLafIDVAKGVRMFSklKVPCVAVVENM 346 thale cress
XP_002259292 281 lneLIKEFInQVDWGvLDYLIIDLPPGTHDiHLNLFEse-diDGVIMITTPNDLsiNDVKKGISMCNyfNIPIVGLVVNM 359 Plasmodium know...
XP_002139379 375 assIVRQLItGTVWGnLDYLILDLPPGTGDiQLSIAQyi-qvDGAIIITTPQDLslSDVERELHLFSklNIPVLALVENM 453 Cryptosporidium...
XP_955520    129 vdqICYEMVyKTNWEgIEYLILDLPPGTSDvIISLVEni-hiSGSILITTPNVLstNDLIKGIKLFRdmEIPILSIVENM 207 Theileria annul...
XP_002787044 132 akeVVAMMLtQTDYGnVTHLVVDCPPGTGDiPNLLLGggvhpSCAVVVTTPHKLslMDTKSGVDKMRrdGVTIGAIVENM 211 Perkinsus marin...
Feature 1                                             ###  ## 
3VX3_A       189 klrseql--------ddekdvEKLAEEfg-vpYLVGIPFYPDLDA 224 Thermococcus kodakarensis KOD1
ADX82282     184 syfnchgkreypfgykdgdvnLPIDPNle--eYIGKIHEYNGDVK 226 Sulfolobus islandicus HVE10/4
CAD26029     222 krftcqkcgh-sksifrsvgvESYCMSng-iaYLGSIDLKQDIAK 264 Encephalitozoon cuniculi GB-M1
XP_001314064 204 geqqcqtcnk--itpaqneagKVLADKyk-lqKICTIPTIPAIVD 245 Trichomonas vaginalis G3
XP_001330320 204 dnercmhcgt-pikhkqpadaIDVSREtn-vdVLTSIPRENAIAI 246 Trichomonas vaginalis G3
CAD90253     347 chfdadgkr---yypfgkgsgSEVVKQfg-ipHLFDLPIRPTLSA 387 thale cress
XP_002259292 360 nsficdgce----knhqlfnnCDLNQLkeefnNVYEIPFHPLLSK 400 Plasmodium knowlesi strain H
XP_002139379 454 syficdgcnk-khyifksgdfSFLYNEyr-ieRKFFFPIYPALSQ 496 Cryptosporidium muris RN66
XP_955520    208 syficecssk--rnifgnskvESICKEfk-ieHFIKLPLMSWDQD 249 Theileria annulata strain Ankara
XP_002787044 212 aylecphcsgiihpfgeadvhCALGLGke--vPVVELPIEATLSS 254 Perkinsus marinus ATCC 50983

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