Conserved Protein Domain Family
ArfGap_ARAP

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cd08837: ArfGap_ARAP 
ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing proteins
The ARAP subfamily includes three members, ARAP1-3, and belongs to the ADP-ribosylation factor GTPase-activating proteins (Arf GAPs) family of proteins that promotes the hydrolysis of GTP bound to Arf, thereby inactivating Arf signaling. The function of Arfs is dependent on GAPs and guanine nucleotide exchange factors (GEFs), which allow Arfs to cycle between the GDP-bound and GTP-bound forms. In addition to the Arf GAP domain, ARAPs contain the SAM (sterile-alpha motif) domain, 5 pleckstrin homology (PH) domains, the Rho-GAP domain, the Ras-association domain, and ANK repeats. ARAPs show phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)-dependent GAP activity toward Arf6. ARAPs play important roles in endocytic trafficking, cytoskeleton reorganization in response to growth factors stimulation, and focal adhesion dynamics.
Statistics
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PSSM-Id: 350066
View PSSM: cd08837
Aligned: 11 rows
Threshold Bit Score: 214.548
Threshold Setting Gi: 156365683
Created: 20-Jan-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Zn binding sitearginine finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:the coordination of the Zn2+ ion by 4 cysteines would indicate that this ion plays a structure stabilization rather than catalytical role.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #  #                 #  #                                        
Q96P48        535 SEVAERIWAAAPNRFCADCGA-PQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDrkVWTETLIELFLq-LGNGA 612  human
FAA00122      260 VMVVNEVWENEANRVCADCGR-ADPDWASINLAIVICKHCAGVHRDLGVHNSKVRSLKMDvrIWTEQMKMLILs-LGNAW 337  Ciona intesti...
CAF92925       65 CVVAEQIWAEPSNSFCADCGI-PKPEWAAINLCVVICNQCAGEHRGLGPSISKVRSLKMDrkVWTEELVKVFLc-IGNER 142  spotted green...
OCT93425      731 LEVAQKIWSVEGNRRCSDCNG-SNPDWASINLCVVMCKRCAGEHRSLGPNISKVRSLKMDhkVWTPELIELFQk-VGNAI 808  African clawe...
KTF93382      261 DGLCESIWRVPSNRMCADCSS-SMPEWASVNLCVLLCEKCAGAHRSLGQNVSKVRSLKLDerVWTDDLIRVFLl-LGNGK 338  common carp
CDQ62144      210 NAVAQKIWSEEANQRCADCGA-PHPDWASVNLCVVLCKCCAGVHMGLGQSVSKVRSLKMDekAWTENQVGTLFllLGNDK 288  rainbow trout
NP_056045     685 YEVAEKIWFNESNRSCADCKA-PDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDasIWSNELIELFIv-IGNKR 762  human
XP_001626773  977 PAVLEYVFTNPSNRKCADCGNkDPYPHASVNHLVCICGNCCGSHRSLGSNISKPRSLLMDkkIWNDDLKELMVk-IGNEN 1055 starlet sea a...
Q8WWN8        489 YEVAEKIWSNRANRQCADCGS-SRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDtsVWSNEIVQLFIv-LGNDR 566  human
Q8R5G7        484 YEVAEKVWSNPANRHCADCRA-SRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDtsVWSNEIVQLFIv-LGNDR 561  house mouse
ETE62615      675 YEVAEKIWSNKANRFCADCHA-LSPGWASINLCVVICKHCAGLHRSLGSRISKVQSLKLDtsIWSNEMVQLFIm-LGNRQ 752  king cobra
Feature 1                                               
Q96P48        613 GNRFWAANVPPSEALqpsSSPSTRRCHLEAKYREGKYR 650  human
FAA00122      338 TNQFWSSNLKSSEAItdmADKKQRAWHINSKYIEMQYT 375  Ciona intestinalis
CAF92925      143 ANSFWAANVPPSEALspsSCREERHHFISNKYHQGKYR 180  spotted green pufferfish
OCT93425      809 SNRFWAANVPPSEAIdvtSSTQERKKFILAKYREGKYR 846  African clawed frog
KTF93382      339 ANQFWGANIPPSESLcssAHSEQRLEHITAKYKDGKYR 376  common carp
CDQ62144      289 VNLFWAANIPPSEMLcpsSDREERQRFVTAKYCQGKYR 326  rainbow trout
NP_056045     763 ANDFWAGNLQKDEELhmdSPVEKRKNFITQKYKEGKFR 800  human
XP_001626773 1056 ANKLLEFKIPDDDRIrpdADSAKRREFICAKYEYKKYS 1093 starlet sea anemone
Q8WWN8        567 ANRFWAGTLPPGEGLhpdATPGPRGEFISRKYRLGLFR 604  human
Q8R5G7        562 ANCFWAGALPPGEGLhpdSAPGPRGEFISRKYKLGLFR 599  house mouse
ETE62615      753 ANKFWAAHLPASEALypdANTKQRRDFIINKYRYGCFR 790  king cobra

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