1M3G,2OUD,2HXP,4YR8


Conserved Protein Domain Family
DSP_MKP

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cd14512: DSP_MKP 
dual specificity phosphatase domain of mitogen-activated protein kinase phosphatase
Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are eukaryotic dual-specificity phosphatases (DUSPs) that act on MAPKs, which are involved in gene regulation, cell proliferation, programmed cell death and stress responses, as an important feedback control mechanism that limits MAPK cascades. MKPs, also referred to as typical DUSPs, function as a protein-serine/threonine phosphatase (EC 3.1.3.16) and a protein-tyrosine-phosphatase (EC 3.1.3.48). They deactivate MAPKs by dephosphorylating the threonine and tyrosine residues in the conserved Thr-Xaa-Tyr motif residing in their activation sites. All MKPs contain an N-terminal Cdc25/rhodanese-like domain, which is responsible for MAPK-binding, and a C-terminal catalytic dual specificity phosphatase domain. Based on sequence homology, subcellular localization and substrate specificity, 10 MKPs can be subdivided into three subfamilies (class I-III).
Statistics
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PSSM-Id: 350362
Aligned: 4 rows
Threshold Bit Score: 229.293
Created: 30-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 9 residue positions
Conserved feature residue pattern:x x C x x x x x RClick to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #                                           #                        
1M3G_A      4 PVEILPYLFLGScshsSDLQGLQACgITAVLNVSascpn--hfegLFRYKSIPVEDNqmvEISAWFQEAIGFIDWvknsg 81  human
2OUD_A      8 LTPILPFLFLGNeqdaQDLDTMQRLnIGYVINVTthlplyhyekgLFNYKRLPATDSnkqNLRQYFEEAFEFIEEahqcg 87  human
2HXP_A      6 PVQILPNLYLGSardsANLESLAKLgIRYILNVTpnlpnffekngDFHYKQIPISDHwsqNLSRFFPEAIEFIDEalsqn 85  human
4YR8_G     25 PTRILPNLYLGCqrdvLNKELMQQNgIGYVLNASntcpk-pdfipESHFLRVPVNDSfceKILPWLDKSVDFIEKakasn 103 human
Feature 1           #######                                            
1M3G_A     82 gRVLVHSQAGISRSATICLAYLMQSrrvrlDEAFDFVKQRRGVISPNFSFMGQLLQF 138 human
2OUD_A     88 kGLLIHCQAGVSRSATIVIAYLMKHtrmtmTDAYKFVKGKRPIISPNLNFMGQLLEF 144 human
2HXP_A     86 cGVLVHSLAGVSRSVTVTVAYLMQKlhlslNDAYDLVKRKKSNISPNFNFMGQLLDF 142 human
4YR8_G    104 gCVLVHCLAGISRSATIAIAYIMKRmdmslDEAYRFVKEKRPTISPNFNFLGQLLDY 160 human

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