Conserved Protein Domain Family
BACK_KLHL2_Mayven
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cd18512: BACK_KLHL2_Mayven 
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2)
KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.
Links
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Statistics
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PSSM-Id: 350587
Aligned: 6 rows
Threshold Bit Score: 286.927
Created: 5-Oct-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative cullin
Feature 1:putative cullin binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of human KLHL3 to Cullin3
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #### #                                                             
O95198       153 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFaDVVLSEEFLNLGiEQVCSLISSDKLTIsSEEKVFEAVIAWVNHDKD 232 human
XP_018098716 169 LHPSNCLGIRAFADMHACTDLLNQANGYAEQHFsDIVTGEEFLNLGiEQVCSLIASDKLTViSEEKVFEAVIVWVNHDTE 248 African clawed ...
NP_001264749 152 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFsDVVLSEEYLNLGvEQVCSLISSDKLTIaSEEKVFEAVIAWVNHDKD 231 chicken
XP_021329567 150 LHPTNCLGIRAFADLHACTELLNLANTYAEQHFsEVVQSEEFLNLGmDQVCSLIASDKLTIpSEEKVFEAVIAWVMHDKD 229 zebrafish
XP_014352761 150 LHPTNCLGIRAFADMHACTELLNHANTYAEQHFsDVVLSEEFLNLGiEQVCSLISSDKLTIpSEEKVFEAVISWVNHDKE 229 coelacanth
XP_007904738 167 LHPTNCLGIRSFADMHACTELLNQANTYAEQHFsEVVFGEEFLNLGiDQVCSLIASDMLTIsSEEKVFEAVIGWVRHDKE 246 elephant shark

Feature 1                                                          
O95198       233 VRQEfmarLMEHVRLPLLPREYLVQRVEEEALVKnssaCKDYLIEAMKYH 282 human
XP_018098716 249 VRQEhmshLMEHVRLPLLSRDYLVQRVEEETLVKnssaCKDYLIEAMKYH 298 African clawed frog
NP_001264749 232 VRQElmarLMEHVRLPLLSREYLVQRVEEEILVKnssaCKDYLIEAMKYH 281 chicken
XP_021329567 230 VRQEhlahLMEHVRLPLLSREYLVQRVEEETLVKnssaCKDYLIEAMKYH 279 zebrafish
XP_014352761 230 VRQEymahLMEHVRLPLLSREYLVQRVEEEALVKnssaCKDFLIEAMKYH 279 coelacanth
XP_007904738 247 ARQEhmarLMEHVRLPLLTREYLVQRVEEETLVKnsnaCKDYLIEAMKYH 296 elephant shark

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