Conserved Protein Domain Family
DEXHc_TTF2

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cd18072: DEXHc_TTF2 
DEAH-box helicase domain of TTF2
Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Statistics
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PSSM-Id: 350830
Aligned: 6 rows
Threshold Bit Score: 366.035
Created: 26-Jul-2017
Updated: 17-Oct-2022
Structure
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Aligned Rows:
 
ATP bindingDEAD box
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of Saccharomyces cerevisiae Chd1 with bound gamma-thio-ATP

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     #######                                             
Q9UNY4        570 LLLHQKQALAWLLwresqkPQGGILADDMGLGKTLTMIALILTQKnqekkeekekstalt-------------------- 629  human
XP_003219235  636 LLLHQKQALAWLLwrenqkPCGGILADDMGLGKTLTMIALILAQKlkqrekgktkekkle-------------------- 695  green anole
NP_001084942  593 LLLHQKQALAWLRwrenqtPRGGILADDMGLGKTLTMVALILMQKqrqnreqekkleew--------------------- 651  African clawe...
NP_524850     439 LMNHQKHALAWMSwrerklPRGGILADDMGLGKTLTMISSVLACKngqemsegkdessdsdseddkn------------- 505  fruit fly
EFV56185      451 LMPHQRQALTWFLwrekqnPKGGILADDMGLGKTLSMISLVMYKKfnrdtreftkghmn--------------------- 509  Trichinella s...
NP_649751     209 LLKHQQSCLKWMQfrerqkISGGILADDMGLGKTLSMIALILASEetknrkreekkkaltlkwtqefnrvyckeirkism 288  fruit fly
Feature 1                                                                                         
Q9UNY4        630 ---------------------------------------------------------------------wlskddscdft 640  human
XP_003219235  696 --------------------------------------------------------------------mwmsrkdstvvn 707  green anole
NP_001084942  652 ----------------------------------------------------------------------isktdstlvv 661  African clawe...
NP_524850     506 --------------------------------------------------------------kkrksvtgwkskgrkdtr 523  fruit fly
EFV56185      510 ----------------------------------------------------------------------dlceaenlip 519  Trichinella s...
NP_649751     289 fddeeesgkeeeqyeppekrtchvktkkinqfrilddddndagdkavvedeqkdllaktpepevfssdeeeehlsngryp 368  fruit fly
Feature 1                           #                                                             
Q9UNY4        641 shgTLIICPASLIHHWKNEVEKrvnsnklRVYLYHGPnrdsra-rvlstyDIVITTYSLVAKeiptnkqeaeipgan--- 716  human
XP_003219235  708 scsTLIVCPASLIHHWKNEIERhvrsgnlKVCLYHGPnriknt-tvlseyDVVVTTYSILAKeiptqkeeveaaaedfvv 786  green anole
NP_001084942  662 trgTLIVCPASLVHHWKKEVEKrvagsrlKVYLYHGPsrerdc-svladyDIVVTTYSLVSKeipvkkeegdapakdqdl 740  African clawe...
NP_524850     524 rggTLVVCPASLLRQWESEVESkvsrqklTVCVHHGNnretkg-kylrdyDIVVTTYQIVARehksls------------ 590  fruit fly
EFV56185      520 sktTLVVCTNSLVSQWNGEINSrvnsgllRVKIFHGAnrerva-anlaryDIVITTYGTISSelgkdkess--------- 589  Trichinella s...
NP_649751     369 sanTLVVCPMSVMCQWAHEVASkvaqnaiRVLTFHGPnrheigieafrsyDLVITSYNLVVNelkrygnt---------- 438  fruit fly
Feature 1                             ##                                                          
Q9UNY4        717 lnvegtstpllriaWARIILDEAHNVKNprVQTSIAVCKLQaCARWAVTGTPIQNnLLDMYSLLKFLRCspfdefnlwrs 796  human
XP_003219235  787 qdkslpfsplpwihWARIILDEAHNIKNpkVQASMAACKLRaTARWAVTGTPIQNnLLDMYSLLRFLRCspfdefkvwrn 866  green anole
NP_001084942  741 edkasssspllrmaWARIILDEAHNIKNpkVQTSIAVCKLRaGARWAVTGTPIQNnLLDMYSLLRFLRCspfdefklwkn 820  African clawe...
NP_524850     591 --------avfgvkWRRIILDEAHVVRNhkSQSSLAVCDLRgKYRWALTGTPIQNkELDVYALLKFLRCspfddlhtwkk 662  fruit fly
EFV56185      590 -----rvsvlgqiaWERIILDEGHTIKNhsTQAAIGCCKLNsIYRWVLTGTPIQNqLKDLYSLIKFLRCepfddlrvwkt 664  Trichinella s...
NP_649751     439 -------splfavyWNRVILDEAHIIRNskTNCCNSVCQLRaHCHWALTGTPVQNrGVDVFALLRFVNVpnfqdlqqwkk 511  fruit fly
Feature 1                                 
Q9UNY4        797 qvdngskkggerlsiltkSLLLRR 820  human
XP_003219235  867 qvdnntrkggerlailtrSLLLRR 890  green anole
NP_001084942  821 qvdngsrkggerlniltkSLLLRR 844  African clawed frog
NP_524850     663 widnksaggqnrlnllmkSLMLRR 686  fruit fly
EFV56185      665 wmdaksesskkrmnslikSMLLRR 688  Trichinella spiralis
NP_649751     512 nln-esmlghrrlnfiikPLMLRR 534  fruit fly

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