3E4E,3RUK


Conserved Protein Domain Family
p450

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pfam00067: p450 (this model, PSSM-Id:365848 is obsolete and has been replaced by 395020)
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Cytochrome P450
Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyze regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.
Statistics
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PSSM-Id: 365848
Aligned: 52 rows
Threshold Bit Score: 245.26
Created: 18-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3E4E_A  12 PPGPFPLPIIGNLFQLeL----KNIPKS-FTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKdefSGrgDLPAFH 86  human
Q02318  61 PRLGQLRFFFQLFVQG-Y----ALQLHQlQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGkypVRndMELWKE 135 human
P15539  42 PQYSRNKWLKMIQILReQg---QENLHLeMHQVFRELGPIFRHSVGKTQIVSVMLPEDAEKLHQVESmlpRRmhLEPWVA 118 house mouse
P15150  42 PRCPGNKWMRMLQIWKeQs---SENMHLdMHQTFQELGPIFRYDVGGRHMVFVMLPEDVERLQQADShhpQRmiLEPWLA 118 cattle
Q07217  50 PGLWRNGLANLYSFWKlDg---FRNIHRvMVHNFNTFGPIYREKIGYYDSVNIIKPEMPAILFKAEGhypKRltVEAWTS 126 rainbow trout
P05108  52 PSPGDNGWLNLYHFWReTg---THKVHLhHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGpnpERflIPPWVA 128 human
P00189  52 PSPGDNGWLNLYHFWReKg---SQRIHFrHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGsypERydIPPWLA 128 cattle
P33270  32 PHDA-PHPLYGNMVGFrKnrvmHDFFYDyYNKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDf--sNFa-DRGQFH 107 fruit fly
P13527  35 PHEE-PHLVMGNVKGLrSkyhiGEIIADyYRKFKGS-DPLPGIFLGHKPAAVVLDKELRKRVLIKDf--sNFa-NRGLYY 109 house fly
P14762  12 PKFQSRAEEFFPIQWYk------EMLNNsPVYFHEET-NTWNVFQYEHVKQVLSNYDFFSSDGQRTTi-fVG--DNSKKK 81  Bacillus megaterium N...
3E4E_A  87 ----AHRDRGIIFNNGPTWKDIRRFSLTTLRNYgmgKQg-NESRIQREAHFLLEALRKTQGQP------FDPTFLIGCAP 155 human
Q02318 136 hrdqHDLTYGPFTTEGHHWYQLRQALNQRLLKPaeaAL--YTDAFNEVIDDFMTRLDQLRAESasgnqvSDMAQLFYYFA 213 human
P15539 119 hrelRGLRRGVFLLNGPEWRLNRLRLNRNVLSPk--AVqkFVPMVDMVARDFLETLKEKVLQNargsltMDVQQSLFNYT 196 house mouse
P15150 119 yrqaRGHKCGVFLLNGPQWRLDRLRLNPDVLSLp--ALqkYTPLVDGVARDFSQTLKARVLQNargsltLDIAPSVFRYT 196 cattle
Q07217 127 yrdyRNRKYGVLLKNGEDWRSNRVILNREVISPk--VLgnFVPLLDEVGQDFVARVHKKIERSgqdkwtTDLSQELFKYA 204 rainbow trout
P05108 129 yhqyYQRPIGVLLKKSAAWKKDRVALNQEVMAPe--ATknFLPLLDAVSRDFVSVLHRRIKKAgsgnysGDISDDLFRFA 206 human
P00189 129 yhryYQKPIGVLFKKSGTWKKDRVVLNTEVMAPe--AIknFIPLLNPVSQDFVSLLHKRIKQQgsgkfvGDIKEDLFHFA 206 cattle
P33270 108 ngrdDPLTQHLFNLDGKKWKDMRQRLTPTFTSG---KMkfMFPTVIKVSEEFVKVITEQVPAAqng-avLEIKELMARFT 183 fruit fly
P13527 110 nekdDPLTGHLVMVEGEKWRSLRTKLSPTFTAG---KMkyMYNTVLEVGQRLLEVMYEKLEVSs----eLDMRDILARFN 182 house fly
P14762  82 s---TSPITNLTNLDPPDHRKARSLLAAAFTPR---SLknWEPRIKQIAADLVEAIQKNSTIN--------IVDDLSSPF 147 Bacillus megaterium N...
3E4E_A 156 CNVIADILFRKHFD-YNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPs--FLhYLPGSHRKVIKNV-AEVKEYVSERVKE 231 human
Q02318 214 LEAICYILFEKRIGcLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWtrpVL-PFWKRYLDGWNAIfSFGKKLIDEKLED 292 human
P15539 197 IEASNFALFGERLGlLGHDLSPGSLKFIHALHSMFKSTSQLLFLPKSl--TR-WTSTRVWKEHFDAwDVISEYANRCIWK 273 house mouse
P15150 197 IEASTLVLYGERLGlLTQQPNPDSLNFIHALEAMLKSTVQLMFVPRRl--SR-WMSTNMWREHFEAwDYIFQYANRAIQR 273 cattle
Q07217 205 LESVGSVLYGERLGlMLDYINPEAQHFIDCISLMFKTTSPMLYIPPAm--LR-RVGAKIWRDHVEAwDGIFNQADRCIQN 281 rainbow trout
P05108 207 FESITNVIFGERQGmLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDl--FR-LFRTKTWKDHVAAwDVIFSKADIYTQN 283 human
P00189 207 FESITNVMFGERLGmLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPEl--YR-LFRTKTWRDHVAAwDTIFNKAEKYTEI 283 cattle
P33270 184 TDVIGTCAFGIECNtLRTPVS-DFRTMGQKV--FT-DMRHGKLLTMFv--FS---FPKLASRLR-MrMMPEDVHQFFMRL 253 fruit fly
P13527 183 TDVIGSVAFGIECNsLRNPHD-RFLAMGRKS--IE-VPRHNALIMAFi--DS---FPELSRKLG-MrVLPEDVHQFFMSS 252 house fly
P14762 148 PSLVIADLFGVP---VKDR--YQFKKWVDILF--------QPYDQER--------LEEIEQEKQRAgAEYFQYLYPIVIE 206 Bacillus megaterium N...
3E4E_A 232 HHQSLDPN-----CPRDLTDCLLVEmek----ekhSae-rLYTMDGITVTVADLFFAGTETTSTTLRYGLL-ILMKYPEI 300 human
Q02318 293 MEAQLQAAgp-dgIQVSGYLHFLLAs---------G----QLSPREAMGSLPELLMAGVDTTSNTLTWALY-HLSKDPEI 357 human
P15539 274 VHQELRLGs---sQTYSGIVAELISq-------------gSLPLDAIKANSMELTAGSVDTTAIPLVMTLF-ELARNPDV 336 house mouse
P15150 274 IYQELALGh---pWHYSGIVAELLMr-------------aDMTLDTIKANTIDLTAGSVDTTAFPLLMTLF-ELARNPEV 336 cattle
Q07217 282 IYRTMRQDtn-thGKYPGVLASLLMl-------------dKLSIEDIKASVTELMAGGVDTTSITLLWTLY-ELARHPDL 346 rainbow trout
P05108 284 FYWELRQKgs-vhHDYRGILYRLLGd-------------sKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY-EMARNLKV 348 human
P00189 284 FYQDLRRKte--fRNYPGILYCLLKs-------------eKMLLEDVKANITEMLAGGVNTTSMTLQWHLY-EMARSLNV 347 cattle
P33270 254 VNDTIALRerenfkRNDFMNLLIELkqkgrvtldnGevieGMDIGELAAQVFVFYVAGFETSSSTMSYCLY-ELAQNQDI 332 fruit fly
P13527 253 IKETVDYReknnirRNDFLDLVLDLknnpesisklG----GLTFNELAAQVFVFFLGGFETSSSTMGFALY-ELAQNQQL 327 house fly
P14762 207 KRSNLSDD-----IISDLIQAEVDGe--------------TFTDEEIVHATMLLLGAGVETTSHAIANMFYsFLYDDKSL 267 Bacillus megaterium N...
3E4E_A 301 EEKLHEEIDRVI-GPs--RIPAIKDRQEMPYMDAVVHEIQRFITLVPs-NLPHEATRDTIFRG---YLIPKGTVVVPTLD 373 human
Q02318 358 QEALHEEVVGVVpAG---QVPQHKDFAHMPLLKAVLKETLRLYPVVP--TNSRIIEKEIEVDG---FLFPKNTQFVFCHY 429 human
P15539 337 QKALRQESLAAE-ASi--aANPQKAMSDLPLLRAALKETLRLYPVGG--FLERILSSDLVLQN---YHVPAGTLVLLYLY 408 house mouse
P15150 337 QQAVRQESLVAE-ARi--sENPQRAITELPLLRAALKETLRLYPVGIt-LE-REVSSDLVLQN---YHIPAGTLVKVLLY 408 cattle
Q07217 347 QEELRAEVAVAR-QSt--qGDMLQMLKMIPLVKGALKETLRLHPVAVs-LQ-RYITEEIVIQN---YHIPCGTLVQLGLY 418 rainbow trout
P05108 349 QDMLRAEVLAAR-HQa--qGDMATMLQLVPLLKASIKETLRLHPISV--TLQRYLVNDLVLRD---YMIPAKTLVQVAIY 420 human
P00189 348 QEMLREEVLNAR-RQa--eGDISKMLQMVPLLKASIKETLRLHPISVt-LQ-RYPESDLVLQD---YLIPAKTLVQVAIY 419 cattle
P33270 333 QDRLRNEIQTVL-EEq-eGQLTYESIKAMTYLNQVISETLRLYTLVP--HLERKALNDYVVPGhekLVIEKGTQVIIPAC 408 fruit fly
P13527 328 QDRLREEVNEVF-DQfkeDNISYDALMNIPYLDQVLNETLRKYPVGVgsALTRQTLNDYVVPHnpkYVLPKGTLVFIPVL 406 house fly
P14762 268 YSELRNN---------------------RELAPKAVEEMLRYRFHIS--RRDRTVKQDNELLG---VKLKKGDVVIAWMS 321 Bacillus megaterium N...
3E4E_A 374 SVLYDNQEFPDPEKFKPEHFLNENG---KF-KYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK--PLVDPKD 447 human
Q02318 430 VVSRDPTAFSEPESFQPHRWLRNSQpatPRiQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVlaPETGELK 509 human
P15539 409 SMGRNPAVFPRPERYMPQRWLERKR--------SFQHLAFGFGVRQCLGRRLAEVEMMLLLHHILKTFQVEtlRQEDVQM 480 house mouse
P15150 409 SLGRNPAVFARPESYHPQRWLDRQG----S-GSRFPHLAFGFGVRQCLGRRVAEVEMLLLLHHVLKNFLVEtlEQEDIKM 483 cattle
Q07217 419 AMGRDPDVFPRPEKYLPSRWLRTEN-------QYFRSLGFGFGPRQCLGRRIAETEMQLFLIHMLENFRVDkqRQVEVHS 491 rainbow trout
P05108 421 ALGREPTFFFDPENFDPTRWLSKDK----N-ITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEiqHLSDVGT 495 human
P00189 420 AMGRDPAFFSSPDKFDPTRWLSKDK----D-LIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEmqHIGDVDT 494 cattle
P33270 409 AYHRDEDLYPNPETFDPERFSPEKV----AaRESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSvcDTTEIPL 484 fruit fly
P13527 407 GIHYDPELYPNPEEFDPERFSPEMV----KqRDSVDWLGFGDGPRNCIGMRFGKMQSRLGLALVIRHFRFTvcSRTDIPM 482 house fly
P14762 322 ACNMDETMFENPFSVDIHRPTNKK------------HLTFGNGPHFCLGAPLARLEMKIILEAFLEAFSHIe-PFEDFEL 388 Bacillus megaterium N...
3E4E_A 448 IDLSpihigFGCIPPRYKLCV 468 human
Q02318 510 SVARi----VLVPNKKVGLQF 526 human
P15539 481 AYRF-----VLMPSSSPVLTF 496 house mouse
P15150 484 VYRF-----ILMPSTLPLFTF 499 cattle
Q07217 492 TFEL-----ILLPEKPILLTL 507 rainbow trout
P05108 496 TFNL-----ILMPEKPISFTF 511 human
P00189 495 IFNL-----ILTPDKPIFLVF 510 cattle
P33270 485 KYSPm---sIVLGTVGGIYLR 502 fruit fly
P13527 483 QINPe---sLAWTPKNNLYLN 500 house fly
P14762 389 EPHLt---aSATGQSLTYLPM 406 Bacillus megaterium NBRC 15308 = ATCC 14581
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