2W49


Conserved Protein Domain Family
Tropomyosin

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pfam00261: Tropomyosin (this model, PSSM-Id:365985 is obsolete and has been replaced by 459736)
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Tropomyosin
Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organisation and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.
Statistics
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PSSM-Id: 365985
Aligned: 22 rows
Threshold Bit Score: 153.612
Created: 19-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2W49_A        41 KKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADES-ERG 119 rabbit
Q6S5G5         6 KKMATLRQTLEDAEARAAKAEDELKNANDRADSAETEVAALTKQLQQLEDDLDAAESKLADTQGQLTEAEKQADES-ERA 84  starlet sea ane...
Q60UW4        20 KKMRQAREEAEAAKDEADEVKRQLEEERKKREDAEAEVAALNRRIVLVEEDLERTEDRLKVATSKLEQATKAADEA-DRA 98  Caenorhabditis ...
P06754       102 KKMRQTKEEMEKYKDECEEFHKRLQLEVVRREEAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADES-ERA 180 fruit fly
Q17H78        17 KKMRQTKEEMEKYKDECEEFHKKLQGEVMRREEAESEVAALNRRIQLLEEDLERSEERLASATAKLSEASAAADES-ERI 95  yellow fever mo...
Q6NN28        48 KKIQTVENELDQTQEALTLVTGKLEEKNKALQNAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADES-ERI 126 fruit fly
XP_001359903  48 KKFVQVEVDLVTAKEQLEKANAELEEKEKLLTSTESEVATQNRKVQQIEEDLEKSEERSTTAQQKLLEATQSADEN-NRM 126 Drosophila pseu...
XP_003372651  48 KKMMQVENELDKAQEELTGANAQLEEKEKKVQEAEAEVAALNRRIQLLEEDFERAEERLKIATEKLEEASQTADES-ERV 126 Trichinella spi...
XP_001634912   9 EKMQQIKDQTDDAEERELGAKSLLKEAEAKEEQLLSEASGIQRRITLLNSELEKTNERVEE-QEKLLQNLVHNSEMnEEA 87  starlet sea ane...
XP_001630767  12 AKLQAIKEKIDETEDRELAAMEKLREAEERFEKAEGEAESFKRRIQLIEAESRRVKELSQKKDHELEEMHKRSKEE-ENL 90  starlet sea ane...
2W49_A       120 MKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKS 199 rabbit
Q6S5G5        85 RKVLENRGASDEERLASLERQYNDALERTEEAEKQYEEISERLQELENELEEAEQKADAAEARVKELEEEVTLVGNNLRS 164 starlet sea ane...
Q60UW4        99 RKSMETRSQQDEERANFLETQVDEAKVIAEDADRKYEEVARKLAMVEADLERAEERAEAGENKIVELEEELRVVGNNLKS 178 Caenorhabditis ...
P06754       181 RKILENRALADEERMDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLKS 260 fruit fly
Q17H78        96 RKALENRTNMEDDRVAILEAQLSQAKLIAEEADKKYEEVARKLVLMEQDLERSEEKVEMNESKIVELEEELRVVGNNLKS 175 yellow fever mo...
Q6NN28       127 RKALENRTNMEDDKVALLENQLAQAKLIAEEADKKYEEVARKLVLMEQDLERSEEKVELSESKIVELEEELRVVGNNLKS 206 fruit fly
XP_001359903 127 CKVLENRSQQDEERMDQLTNQLKEARMLAEDADTKSDEVSRKLAFVEDELEVAEDRVRSGEAKIMELEEELKVVGNSLKS 206 Drosophila pseu...
XP_003372651 127 RKVMENRSLQDEERVYQLEAQLKEAQLLAEEADRKYDEVARKLAMVEADLERAEERAEAGENKIVELEEELRVVGNNLKS 206 Trichinella spi...
XP_001634912  88 RKGLEESEMKGDEKIMDLEAKLKEMERVEKETLETLTEAERKEVVVTRDLERAIEKGRTLENRIQSLESTMGNALTNIQK 167 starlet sea ane...
XP_001630767  91 CKTLEVTDRESDEKMRELEDALEEAIELDKSTADKLAEVELKIKVVQGELEKAVERGDRAEMMCEHLMNDFTGTSEVLRD 170 starlet sea ane...
2W49_A       200 LEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMT 275 rabbit
Q6S5G5       165 LEISEGKASEREDTYENQIRELETKLQDAEERAEKAEQKVQELEAQAEAMEAELEKAKEQYEKVKEELDSTLAELS 240 starlet sea anemone
Q60UW4       179 LEVSEEKALQREDSYEEQIRTVSSRLKEAETRAEFAERSVQKLQKEVDRLEDELLLEKERVRNLTEEIEQTVQEIQ 254 Caenorhabditis brig...
P06754       261 LEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLVLEKERYKDIGDDLDTAFVELI 336 fruit fly
Q17H78       176 LEVSEEKAMASRDSVEDKIHQLNDKLTNAEARAEFAERSVQKLQKEVDRLEEEVTKEKSKYKAIAAELDLTFADLS 251 yellow fever mosquito
Q6NN28       207 LEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLVLEKERYKDIGDDLDTAFVELI 282 fruit fly
XP_001359903 207 LEVSEEKANQRVEEFKREMKTLAIKLKEAEQRAEHAEKQVKRLQKEVDRLEDRLFNEKEKYKAICDDLDQTFAELT 282 Drosophila pseudoob...
XP_003372651 207 LEVSEEKALQREDSYEEQIRLLTQRLKEAETRAEFAERSVQKLQKEVDRLEDELVHEKEKYKAISEELDQTFQELS 282 Trichinella spiralis
XP_001634912 168 LEASGDEAYEREELKEEKLKFFQEQLKQYEQRYEDAEREALKLERINDTIIIEIDSYKKKKEEILREMDLELVDLN 243 starlet sea anemone
XP_001630767 171 LEVKDAAASEREIDNEDKIEFIQENLKQMVYRYEEAERKAPPLEMLLDQLVEDLELYRLKRKQVDEEM-KAMGELV 245 starlet sea anemone
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