2HYE,5N4W


Conserved Protein Domain Family
Cullin

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pfam00888: Cullin (this model, PSSM-Id:366357 is obsolete and has been replaced by 395716)
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Cullin family
Statistics
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PSSM-Id: 366357
View PSSM: pfam00888
Aligned: 406 rows
Threshold Bit Score: 133.834
Threshold Setting Gi: 121888259
Created: 3-Jun-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2HYE_C    63 WRKLHEAVRAvq--ssTSIRYN-------LE-ELYQAVENLCS--HKVSPMLYKQLRQACEDHVQAQILPFR-------- 122 human
EDO17336  26 WISLESAFRMif--knDVNELS-------YQ-DLYRTVYLQTV--RGKADVLYQKIEEFVREQIKLAYSENVlnsgannp 93  Vanderwaltozyma pol...
CCH62090  25 lleITDAIDSiy--leKTEVLS-------FE-KLYRHIYLIVI--NGAGSKLYGEIEKFMSSKLRELRNDFTi------- 85  Tetrapisispora blat...
Q24DT3    29 nqnyfeknwleieqflKSIYESedincycFQ-HFYDMISSICD--NEFDELLYKKLEEFYRLKFNVILNDI--------- 96  Tetrahymena thermop...
EAY00754  70 mayLKEGIHLlf--ddKIQNAN-------FA-KLFTNVEYICR--NKTPEYLYKSISEDMQEAALNFIN----------- 126 Trichomonas vaginal...
EAY01000  15 lEEISKSITSil--thKHSSLS-------LS-YLYNCMNNLVN--NSCTNKLRDTLQNHLDKQFSKQYNSLS-------- 74  Trichomonas vaginal...
EAX93741  14 vKRVEEGLDSii--hrQPCKHD-------FN-SLYSSTDKIIN--NDNQAKLFDLLNNKINEEIAKWEKQL--------- 72  Trichomonas vaginal...
A0BYN1    18 WKYLDDACYLia--ehQTKQLS-------FA-ELYQHAYKLIL--NKFGDFAYSQLQISIHNVVDKLISPL--------- 76  Paramecium tetraurelia
Q236H3    55 WDVIEQAIQMiy--ekKTHTLS-------YQ-ELYHHAYILAF--YGHGDQAYSRLKSLLEKYSLKMLNTLG-------- 114 Tetrahymena thermop...
A0CFE8    15 iNNLRDHIEKvlkgekKVYNTK-------ETmTFYTEIFNYIVqgEQQGQKMYDLFKGYNEDFLKESEKIARq------- 80  Paramecium tetraurelia
2HYE_C   123 -----EDSlDSVLf-LKKINTCWQDHCRQMIMIRSIFLFLDR---------------TYVlqnS--TLPSIWDM-----G 174 human
EDO17336  94 kddsnNSD-DSYNy-LLKMSKLWKFECNCFKSLSSVLLYLDK---------------VYS---KknKKLEIYDL-----C 148 Vanderwaltozyma pol...
CCH62090  86 ----dETQ-DEMGf-LKNLNQFWLNQCKYFKIINDLMSYFNK---------------VYC---KeeRKFEVYDL-----C 136 Tetrapisispora blat...
Q24DT3    97 ------AL-QPEDf-INKIEKEWIKINRCLIILSEIFKQFEG---------------SY-----------LYKT-----K 137 Tetrahymena thermop...
EAY00754 127 -------S-ISEEfdITLISQKISLFEKCLDYFLRTFLYLDR---------------SY-----------IFPLri--dG 170 Trichomonas vaginal...
EAY01000  75 -----KTA-LVNPl-VIKFSKHCSYFASFLKILPKLYSRYDEsla---------ensEY----------RTEKI-----L 123 Trichomonas vaginal...
EAX93741  73 -----KEV-TSNSl-LSLFSTLYDNFKIYSDIIPKIYSSYDSksspenksrmiirriYF--------------------K 125 Trichomonas vaginal...
A0BYN1    77 -----NIS-NDDQl-LYDFVQAFEEVQHFSKLLAGILLYMEK---------------SYilqk---slkTIKTI-----C 126 Paramecium tetraurelia
Q236H3   115 -----YYD-SEEQi-LVKMVAVWQDYKQMINILKGIFLYLDN---------------NYvttk---nlqPVLVL-----G 164 Tetrahymena thermop...
A0CFE8    81 -----SLK-SDKNf-IEEILYQHEIYEIHTRILQSYFTYLDRsfvev-----lnntsQY----------PNLKQqakkqF 138 Paramecium tetraurelia
2HYE_C   175 LELFRTHIIs-------DKmvqSK---TIDGILLLIERERSGEAVD----R-SLLRSLLGML----SDL----------- 224 human
EDO17336 149 LELFKTNLL--------NPa-kEQ---LLKAIIIDINNIRNLKSINnd-hI-DIWRQIISML----ETIeek-------- 202 Vanderwaltozyma pol...
CCH62090 137 LNLFRIDIV--------IPl-hES---ISNKIINQINKVRYNNELLyianT-DIWKSIFNML----ETLqdvd------- 192 Tetrapisispora blat...
Q24DT3   138 TPSFDNFILkilsdqfnQEf-nSLldaIITSLLDTFRNIR-----DqnpyNhEQLKHLMGMI----IKIg---------- 197 Tetrahymena thermop...
EAY00754 171 FTSLSEIVYsyirngmsKEl-aDL---ISDQILITISKYR--------------LHEEIKLS-----ELktgln------ 221 Trichomonas vaginal...
EAY01000 124 FTKFKEKVLn------qTKv-vDL---IIKSMIDVIEDAR----TNrivsGtANLRQIIELF----Y------------- 172 Trichomonas vaginal...
EAX93741 126 LVISDRSIIs----------------sVTKALLKQIDYFR----DTptdtNySIPKNIVDSF----Y------------- 168 Trichomonas vaginal...
A0BYN1   127 NESFKIKCFek-----dQNl-aNK---LLNCFLSQIRNDR-----NsqfiEhFKLKKALQIL----IDLnqeqqiknkey 188 Paramecium tetraurelia
Q236H3   165 YEVFQQILFiq-----kSEi-ySK---VLEIILTMIDKQRLGen-----iEgQLIQKIIQMS----VDLgmkaniqkcnq 226 Tetrahymena thermop...
A0CFE8   139 YEQFYNKLFf----------------sIKEEFKAKLKLDR------------ILLDKESQLLlqrvYKI----------- 179 Paramecium tetraurelia
2HYE_C   225 -------------QVYK----------DSFELKFLEETNCLYAAEGQRLMQ-E------ReV-PEYLNHVSKRL---EEE 270 human
EDO17336 203 -----------kdNYFI----------NHFENPLVVESEKYYDE----QISlE------NvPfKEYLKNIEELT---KFE 248 Vanderwaltozyma pol...
CCH62090 193 ----------dkdNYFI----------TYFEPKFIQRTENFYSN----FLNvD------SlTlDDYLVKVEKIK---SFE 239 Tetrapisispora blat...
Q24DT3   198 --------------SYE----------NQFKSHFFEQSNKYYLDLQQKHRA--------NfDlRVYLQEIEHRL---QQE 242 Tetrahymena thermop...
EAY00754 222 --------fakstKFYN----------DHLEPTLLIQTKDYFED-ISSHLS-LkdlinwNySs----KEIETQLqecGLE 277 Trichomonas vaginal...
EAY01000 173 --------------EYKnsncd-rsifENFMASLKESTKKKYEN---EYNS--------SeNfVEFLKRIKELL---DFE 223 Trichomonas vaginal...
EAX93741 169 --------------QFNpdcdennkilATFKIDFTGGVYAYFNQ-FFEKRN--------EcDiAKYTSDSFTHL---TLE 222 Trichomonas vaginal...
A0BYN1   189 ---nytidyrindDFYK----------HFLERKLIQDSRSYFKEESQSNLN--------KmTiEEYILFVEKRY---LDE 244 Paramecium tetraurelia
Q236H3   227 ysrqiqyeyipelTIYE----------KYFEKGYLDCSEKYFSEESQRLIL--------QlSpKDYIIAVERRF---LEE 285 Tetrahymena thermop...
A0CFE8   180 --------------IYGmktfqdignnQLIQKEIKEDSKTYYQQQYSNFQQ------------QSFLDQIKSLVqfkQEE 233 Paramecium tetraurelia
2HYE_C   271 GDRVI--------TY-L-DH----STQ-------KP-LIACVEKQLLG-EHL---------------TAILQK--G---L 307 human
EDO17336 249 FDLDI--------KF-V-NT----DTA-------SK-IKSALDESLVW-KRV---------------SKDLPTyiR---- 286 Vanderwaltozyma pol...
CCH62090 240 NHLDN--------YF-L-NP----DTT-------LK-IISILDKCLVW-NNI---------------MDKVPAyvK---- 277 Tetrapisispora blat...
Q24DT3   243 TGLIE--------AY-L-SK----ATG-------KI-LIDLIQKHLIA-ENL---------------ETIFSNgfD---- 280 Tetrahymena thermop...
EAY00754 278 KS-----------TY-LsIDsmqnEIV----------LKKAGQRVLFS-QEF---------------YDMIDQ------F 313 Trichomonas vaginal...
EAY01000 224 EN------------LlL-------KAIfkdeedvNE-ILMIAHESAIF-KNTetfanqkdfqvppiySALQDK------- 275 Trichomonas vaginal...
EAX93741 223 EN--------------I-------IST----------IFRKVEADLMFkESVcalfdygdffdidksINVAPL------L 265 Trichomonas vaginal...
A0BYN1   245 VDRVQ--------HY-I-PK----ISH-------QK-VLDCFIKIYIT-SNA---------------------------- 273 Paramecium tetraurelia
Q236H3   286 KKRVH--------SY-F-YQ----TSK-------NK-IQSLFFQKYIN-DFA---------------KAIVDN--QengL 325 Tetrahymena thermop...
A0CFE8   234 LGRIRlifgceqsE--L-----------------QKeLIDLFNNYIIN-SYA---------------SDLNSD--NndtL 276 Paramecium tetraurelia
2HYE_C   308 D---HLLd----------EN----------------RVPDLAQMYQLFSRVr------GGQQA-LLQHWSEYIK------ 345 human
EDO17336 287 ----FCI-----------KEn---------------DPSILQKLYDLSSKe-------ENMVS-IIEALKLCIE------ 322 Vanderwaltozyma pol...
CCH62090 278 ----DLI-----------QVs---------------NNDQLKKLYSLSLNe-------EYKGK-IISTVSECIL------ 313 Tetrapisispora blat...
Q24DT3   281 ----DLLnq--------rD------------------YQNLQRLFHNMRNIdkl--------dfLKKNWNQYIR------ 316 Tetrahymena thermop...
EAY00754 314 D------------------------------------KEELKRVVSTFDKEe--------LRKlLLKSVSSYFS------ 343 Trichomonas vaginal...
EAY01000 276 ----NLL------------RwlirdsylrfhqknhiMCEFIPKICEFMTKD---------IKS-FEPKFSDHMKlnd--- 326 Trichomonas vaginal...
EAX93741 266 EkdeTDL------------------------------LDRLNKLTRLYMNGrvepdinR-VEP-LIDLLCNYIKnrmlsf 313 Trichomonas vaginal...
A0BYN1   274 ----QHIsqglydfieneK------------------TAIIIIIFQLFVKSeef--------dlFVKTFSQIII------ 317 Paramecium tetraurelia
Q236H3   326 F---NWLdn--------dE------------------VVIIKKSHTLFQNTkes--ytI-----FLNIFYKYVA------ 363 Tetrahymena thermop...
A0CFE8   277 K---NIIiq--------dY------------------YEQFGQLVKFFDHFksn--thI-----FVRKFQEIII------ 314 Paramecium tetraurelia
2HYE_C   346 ------------------TFG-----TAIVINp----------------------------------------------- 355 human
EDO17336 323 ------------------RDL-----ESIIIDtnmk-------------------------------------------- 335 Vanderwaltozyma pol...
CCH62090 314 ------------------DALkestdNNINDNtkri-------------------------------------------- 331 Tetrapisispora blat...
Q24DT3   317 ------------------RKG-----EEIVNe------------------------------------------------ 325 Tetrahymena thermop...
EAY00754 344 --------------------------TKIKSTiq---------------------------------------------- 351 Trichomonas vaginal...
EAY01000     --------------------------------------------------------------------------------     Trichomonas vaginal...
EAX93741 314 rpqfedgpaksenkeegaKEGgd-eeKAAPAKktvakktvakkiikkkvvakkedneekeddeekeneekpttaepkmri 392 Trichomonas vaginal...
A0BYN1   318 ------------------DDL-----QILNQNan---------------------------------------------- 328 Paramecium tetraurelia
Q236H3   364 ------------------HQT-----SALAARq----------------------------------------------- 373 Tetrahymena thermop...
A0CFE8   315 ------------------QQG-----QEIIVEqknrisqt---------------------------------------- 331 Paramecium tetraurelia
2HYE_C   356 ----------------------------EKDKDMVQDLLDFKDKVDHVI--EVCFQ------K-------NER----FVN 388 human
EDO17336 336 -------------------------kknIVANKWASSLIEIYNYYDKFL--NDFDF------GnvnlqdkDANssqlFSQ 382 Vanderwaltozyma pol...
CCH62090 332 -------------------------kktQMSLNWISSVLEIYNKYKALL--SCMKTd--------------------KFS 364 Tetrapisispora blat...
Q24DT3   326 ----------------------------ENQDDITQHLLDFFHDLDIII--QKCFE------N-------TNL----LKQ 358 Tetrahymena thermop...
EAY00754 352 ---------------------------sSTDQTLIPDILRIISKISDFD--QFIFE------N-------SRD----AVK 385 Trichomonas vaginal...
EAY01000 327 --------------------------kiTQIHEIIKKVLSQTEPFEFVFcsQEHMRkksddpNfdmekeaREK----FEK 376 Trichomonas vaginal...
EAX93741 393 vkkatpkagtasaaeksskskigkdekiTAMKDLIFTALKLYSNFNKIF--QDSSD--------------KKK----MSN 452 Trichomonas vaginal...
A0BYN1   329 --------------------------tlQGFIKLYEKIFSLYDKIAQYGnnEHQYK---------------------FHK 361 Paramecium tetraurelia
Q236H3   374 ---------------------------sTPVKEYIEDIILFRLKIINIM--QEAFF------S--------------LLK 404 Tetrahymena thermop...
A0CFE8   332 ---------------------kikqekeDQKSKFLEQLISLQQSYKKLI----------------------------YDH 362 Paramecium tetraurelia
2HYE_C   389 L---------MKESFETFI-Nk-----rPnkPAEL-----IAKHVDS--KLR---A-G--NKEa-------------T-- 425 human
EDO17336 383 I---------ILSVFSGYM-Ckn---slL--YTEL-----VTIYLDS--YLK---N-L--EDNn-------------A-- 419 Vanderwaltozyma pol...
CCH62090 365 I---------LNENLMKYL-Kdl---enL--TIES-----VIIYLDT--FLK---L-S--SNEnlynatnnhtnsdrS-- 414 Tetrapisispora blat...
Q24DT3   359 A---------KNYALEHVL-Sik---vnT--IAEL-----TSKHIDT--KLKkqnKt--------------------Mqd 396 Tetrahymena thermop...
EAY00754 386 T---------INESVSASMsSqr----dH--IAEY-----LARYIDSgnPLV---GpS---------------------- 420 Trichomonas vaginal...
EAY01000 377 A---------ITAGWNIPAfN----------IVEN-----FVQYIDF--HIKnekKrL---------------------- 408 Trichomonas vaginal...
EAX93741 453 A---------VEQAWN---------------AKEFrphynLVQFIHY--------SvVnnLENi---------------- 484 Trichomonas vaginal...
A0BYN1   362 A---------IKNAFEQVI-NkdnfimmE-----------LNIYFDF--LMK---Ke--------------------Tlr 395 Paramecium tetraurelia
Q236H3   405 TddqltiqrqTQKSFEDSL-Nds----nF--PTEQ-----LNCYIDE--AFQkdfK----NKS----------------- 449 Tetrahymena thermop...
A0CFE8   363 AennqfllanLRVAFEMITaN----------AEQH-------FIMES--LLQklhTfT--LKRi---------------- 405 Paramecium tetraurelia
2HYE_C   426 DEELERTLDKI-MILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAE---KSMLSKLKH--ECGA--AFTSKLEGMFKD 497 human
EDO17336 420 ISEAKNHLDQY-VRIFITLPEKDVFESQYRKFLSRRLLQQRSIF-NLE---KWLVQRFKE--ELGT--FFTSKMEGMLRD 490 Vanderwaltozyma pol...
CCH62090 415 TDTIKKNIKDC-TILLKFINEKDYFEIFYKKLLSKRLLQNRSNF-ELE---KWLVGIIKT--EMGS--FVTIKIEGMLRD 485 Tetrapisispora blat...
Q24DT3   397 HDQIEKDVDDA-LELFRYLPAKDIFEAFYNKRLARRLLMNLAYSYELE---RKVLDRLRS--ECGD--QYTMKADEILKD 468 Tetrahymena thermop...
EAY00754 421 ------------LILFKLIDASEVFESTYFHLFGRRFLSWNVDV-QRE---NELIDTLQM--NASK--EYTDRLVKTIND 480 Trichomonas vaginal...
EAY01000 409 SKTENENFERTcARFFRYTEDKVGFCTTYEQALLQRLIKFLTKF-DAEe--RMMIETISK--EKQP--EFMKGYKDLKAC 481 Trichomonas vaginal...
EAX93741 485 PDEYKSKFPQIcKLFFDFTTDKAVFVPLFMNYQIQRIIKNRESEQDTRaleFEIVKQLKSigASSNteDFGKHLEEIYNQ 564 Trichomonas vaginal...
A0BYN1   396 DEEKKLQIDKG-FLIFKLVQSKDEFEQIYRKHLCVRLLDQTYSSLEVE---KDLLKKLRL--ECGS--VLTHKMETMFSD 467 Paramecium tetraurelia
Q236H3   450 EQQIEEVLNSV-FEIFCLIRNKDYFASIYMKSLAKRILYNKSLDENNE---KQIISKFKL--ECGT--VYTKKMETMFLD 521 Tetrahymena thermop...
A0CFE8   406 DIGEEKQLKEV-MQLLECFQAKDLLLRNYQNKLAQRILTLFDYHSDFD---KQIIDQFRK--TYGP--EHTKQLESMIKD 477 Paramecium tetraurelia
2HYE_C   498 MELSKDIM------V-HFKQHMQn---Q-SDSGPID------LTVNILTMGYWPTYTPM-E------------------V 541 human
EDO17336 491 INNSKDLL------R-SFKNSNSn--tNsLINLNLN------YNPEILTAISWPFNNnnqd---------------nneI 540 Vanderwaltozyma pol...
CCH62090 486 INKSKELL------I-NFKKSEd------LN--NIA------YIPEILTISSWPFVSEL-Ntd---------------lI 528 Tetrapisispora blat...
Q24DT3   469 VNESKQLN------K-DFNDY--------LSSQGLDynkkniFSCIVVSSSAWPMKNQQlP------------------- 514 Tetrahymena thermop...
EAY00754 481 YNQSKRILqptsdgM-EYKA----------------------M---ALYERDWSTNEGE--------------------I 514 Trichomonas vaginal...
EAY01000 482 IDNSAQID------D-DFKK-----------------------QI-MNTKIEWPDGMREvQfspivfnknhyklyiieqT 530 Trichomonas vaginal...
EAX93741 565 VRISIDTT------K-NFKATI-------PSDSQVD------FIATVLNHNIVEKFATDnA------------------F 606 Trichomonas vaginal...
A0BYN1   468 LERSSEDS------Q-KFRQKLSq-----NQRDSID------LDILVLTSEQWPITDSQp-------------------I 510 Paramecium tetraurelia
Q236H3   522 MQQSLEYY------N-EFKQLFIknlnTkSAYKSLD------FDIKVLTCGNWPYKLNQfSq-----------------V 571 Tetrahymena thermop...
A0CFE8   478 YEQQKNEE------KiTISD--------------IE------IQAKILQKEYWPEIRPQlNld---------------nI 516 Paramecium tetraurelia
2HYE_C   542 HLTPEMIKLQEV-FKAFYLG--K-HSGRKLQWQTTLGHAVLKAEFKEG------Kk-EFQVSLFQTLVLL-MF-N--EGD 606 human
EDO17336 541 ILPVKLKEVQED-FEKFYKK--K-YSQRTLTWSPTLSMIEVSYQFDKT------Qh-DLILPFYSAIIFL-LF-E--EYD 605 Vanderwaltozyma pol...
CCH62090 529 ILPKELLEIQQN-FQTFYSS--KnYNDRTLSWQFNLQTIELRCSINKN------Iy-ELIMPFYSSLILL-LF-N--ENE 594 Tetrapisispora blat...
Q24DT3   515 ILFEPFDKFQKE-FKKFYEL--K-HKGVCINWQHETSTCDIQGNYNK-------EkyIFQVQLIQGLILL-CF-NlkN-- 579 Tetrahymena thermop...
EAY00754 515 KFPEQIEILNEE-FKKRYMKqqKtDSHIVLHFSAALSNCVLKVNNKS----------EIKMSGEQAIIVL-LL------S 576 Trichomonas vaginal...
EAY01000 531 KIPEFLSPVHDR-FIQFYQE--K-NKSMTLMLLADTSTVQSKWRIPKNsksnkpEtyVLTTDILTSKILSyLHkNq-TE- 604 Trichomonas vaginal...
EAX93741 607 KIMPFLQDLHNR-FVGFYQQ--N-HQNSDLKIIPDISQLQFTFRVPKNkksanlKvyTINTDAWGGSILMaIY-E----A 677 Trichomonas vaginal...
A0BYN1   511 IIHTELLLWQQQ-FTQYYQS--K-NSKRKLSFNYGLGSVSLKATFDQN------SkkDFVCSVFQATILM-HF-Nk-QR- 576 Paramecium tetraurelia
Q236H3   572 KIPNQLEPYISE-FEKHYKS--K-FKGRKLKWIYSVGKSIVKG-YYSFn----nSkkEFQVSNVQMVILL-LF-Nn-KI- 638 Tetrahymena thermop...
A0CFE8   517 LILNQLKAAYREkFNSQQEK----NQLIDISWQDQLSMVELMFRTNQe--------yKVIIGVVGGAILL-QF-N----H 578 Paramecium tetraurelia
2HYE_C   607 ---GFSFEEIKMATGIEDSELRRTLQSLACGK--AR-V---LIKSPk--------G-K-EVED-GDKFIFNGEF 660 human
EDO17336 606 ---QLSLEKISELTNIPNQELIRHLLSLSIAPr-AK-L---LTKEPp--------T-R-NISP-NDKFSINKSF 660 Vanderwaltozyma polyspora...
CCH62090 595 ---IYSTSEIKEKTNLPEAELIKQLLSLTIAPk-CK-I---LKKSPp--------G-T-NISL-DDKFSINVSF 649 Tetrapisispora blattae CB...
Q24DT3   580 ---KLSYTEIHNLVQIDEEELKKNLVSLYAMKdtQK-L---LNK-----------SgEaKRVDeTDVFEVNEAY 635 Tetrahymena thermophila S...
EAY00754 577 ekgPMNVDDIHNHTGINESQIKINLDIL--SKkpLN-L---LIKg------------D------DDKWSVNKDA 626 Trichomonas vaginalis G3
EAY01000 605 ---KVSVQDIIMYTQEEKPLVKKCIAKL---------LglqICV-RektvkttekQqQqQLSD-TDLIMMNKef 664 Trichomonas vaginalis G3
EAX93741 678 ketGLKKADINAITAVKEDLVDAYLKMM---------YhmkLIAmkdk----gasNkMeDIEW-----VLNKNF 733 Trichomonas vaginalis G3
A0BYN1   577 ---VYKVDELIKLTNSDKEIMQYELENL---------LqfkLLI---------------QNEE-ENSLQLNQKF 622 Paramecium tetraurelia
Q236H3   639 ---KYTQQELTALLQMPYEEYKLHLLPL---------VqlkILK-----------SeN------NIDFEYNDQF 683 Tetrahymena thermophila S...
A0CFE8   579 qnnPQTSEQLAQSIGVNNQYFLNQIKLLe-----SKkL---LTRD-------------------GQAYKFNEEf 625 Paramecium tetraurelia
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