4GIW,2DWG


Conserved Protein Domain Family
RUN

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pfam02759: RUN (this model, PSSM-Id:367169 is obsolete and has been replaced by 397055)
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RUN domain
This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.
Statistics
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PSSM-Id: 367169
View PSSM: pfam02759
Aligned: 40 rows
Threshold Bit Score: 90.7857
Threshold Setting Gi: 402550730
Created: 13-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4GIW_A     54 TLCPALHALVADGLKPFRK------------------------------------------------------------- 72   human
Q6NXD8   1163 GLVWALEQFFHHGFRs---------------------------------------------------------------- 1178 zebrafish
Q54LN3   1015 RLATAIANLVSHGFIVSPTnmvgsifrnvingat---------------------------------------------- 1048 Dictyostelium dis...
Q94222    607 RLANSFRQIMDHGIRENALytsmayh------------------------------------------------------ 632  Caenorhabditis el...
Q17FM5    615 TLAPTIKQVLEHGMKRPSFlggpch------------------------------------------------------- 639  yellow fever mosq...
Q96C34    429 ELTVAVRDLLAHGLYASSPgmslvmapiacllpa---------------------------------------------- 462  human
Q9W5C1    516 NFARTLQQLIQHGLRIPAEsaasslmvpfmrclhpgppvvpp-------------------------------------- 557  fruit fly
Q17Q22    446 QLAKTIQGLMQHGLRGITEssgslvpfisgcfsgggyhsqgpsknsaeerfyrgdsrrkstggmtkaattppkrnsssle 525  yellow fever mosq...
PNJ37530    8 TLCPALKALFEHGLKKPSLlggach------------------------------------------------------- 32   Sumatran orangutan
CAF87805   39 ELAPALKDLLAHGLFSPSQtmslvlapiscllph---------------------------------------------- 72   spotted green puf...
4GIW_A     73 --------------------------------------D-LITGQRRSSPWSVVEAS-----------------VKPGSS 96   human
Q6NXD8   1179 ----------------------------------------ARIFQKNVFVWDFFERIvafmenrdqtgdlqespEPLSLN 1218 zebrafish
Q54LN3   1049 -----------------------gsggggsgggnslssSlGNIVTGKRHLWEFIENY-----------------KKTTQH 1088 Dictyostelium dis...
Q94222    633 --------------------------------pwsfieD-IAYYSVEKNFNSVYSRLtlcntf------nldedGKILTP 673  Caenorhabditis el...
Q17FM5    640 --------------------------------pwlfieE-AATREVEKDFESVYSRLvlckty------rldedGKVLTP 680  yellow fever mosq...
Q96C34    463 ------------------------fssapeamhpwelfVkYYHAKNGRAYVESPARKlsqsfa------lpvtgGTVVTP 512  human
Q9W5C1    558 ----------------avggdsqflglgramhawelvlA-YYRLKHGEEYNNTPARKlsqsfq------ldivdAQAVTA 614  fruit fly
Q17Q22    526 eeepiemnlftqleededeeveycdgdesemhawelllL-YYNIKNGDRYNSAPARKlsesfn------ldlveGRPQSN 598  yellow fever mosq...
PNJ37530   33 --------------------------------pwlfieE-AAGREVERDFASVYSRLvlcktf------rldedGKVLTP 73   Sumatran orangutan
CAF87805   73 ------------------------qpapqalhpwdlfvK-YYHSKNGRAFVESPARQlsqsfs-----lpvggaAVTVTP 122  spotted green puf...
4GIW_A     97 trSLgtlYSQVSRLAPLSSS----------RSRFHAFILGLLNTKQLELWFSSLQEDAG---LLSLXYXPTGFFSLARGG 163  human
Q6NXD8   1219 seSL---CRYVNAINNMPRNig-------kDGKFQLLVCLGARDRLLPQWLPLLAESP----VITRMYEENALLRDKLTV 1284 zebrafish
Q54LN3   1089 gtIAg--ISLIQTINTINSFenissawkdpNIKFRTLICVGLNQHVLDQWFALLQTDTN---GISHYFHPNAIINSLDHW 1163 Dictyostelium dis...
Q94222    674 eeLL---FRSVQLINDSHNAvsa-----hsDVKLRSLLVVGVNEQCIHLWFDLLCSATQhehIRNKYYHSWAFIRSPAWR 745  Caenorhabditis el...
Q17FM5    681 eeLL---YRCVQAVNQSHDAaha-----qmDVKLRSLICLGLNEQVLHLWMEVLCSCSE---IVHKWYQPWSFIYSPGWV 749  yellow fever mosq...
Q96C34    513 kqSL---LTAIHMVLTEHDPfkr-----saDSELKALVCMALNEQRLVSWVNLICKSGS---LIEPHYQPWSYMAHTGFE 581  human
Q9W5C1    615 kqSL---LSAVGMILAMHRPykr-----snNAHFKAFVCAGLNSHLLVEWLNLILSCHE---LVDTYYSADSYVARTGFR 683  fruit fly
Q17Q22    599 kqSL---LSAIGTIIALHSPykr-----syNSQFKAFICAALNAQKLTQWLHLIYQCKE---LVSSYYTSWSYVANTGFR 667  yellow fever mosq...
PNJ37530   74 eeLL---YRAVQSVNVTHDAvha-----qmDVKLRSLICVGLNEQVLHLWLEVLCSSLP---TVEKWYQPWSFLRSPGWV 142  Sumatran orangutan
CAF87805  123 kqSL---LWAIHSVLKEHGRykr-----gpDTKFKALVCMALNEQRLVSWLNLLCKSG----TLVDHYQAWSYMAQTGFE 190  spotted green puf...
4GIW_A    164 cpslstEL-LLLLQPLSVLTFHLDL 187  human
Q6NXD8   1285 s-----SL-LGVLETLHDFPITLET 1303 zebrafish
Q54LN3   1164 r-----LF-CQCFAPILNLPFKLSL 1182 Dictyostelium discoideum AX4
Q94222    746 ------QI-KCDLRLLSQFSFNLSM 763  Caenorhabditis elegans
Q17FM5    750 ------QI-KCELRLLSQFAFNLNP 767  yellow fever mosquito
Q96C34    582 ------SA-LNLLSRLSSLKFSLPV 599  human
Q9W5C1    684 ------DS-LRSIDALSRFDFDLPV 701  fruit fly
Q17Q22    668 ------DA-LKTLDRLTQYRFDLPV 685  yellow fever mosquito
PNJ37530  143 ------QI-KCELRVLCCFAFSLSQ 160  Sumatran orangutan
CAF87805  191 -------GaLRILGRTSHLKFSLPV 208  spotted green pufferfish
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