2B1E,2PFT


Conserved Protein Domain Family
Exo70
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pfam03081: Exo70 (this model, PSSM-Id:367324 is obsolete and has been replaced by 460798)
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Exo70 exocyst complex subunit
The Exo70 protein forms one subunit of the exocyst complex. First discovered in S. cerevisiae, Exo70 and other exocyst proteins have been observed in several other eukaryotes, including humans. In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localized at the tip of the bud, the major site of exocytosis in yeast. Exo70 interacts with the Rho3 GTPase. This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud). In humans, the functions of Exo70 and the exocyst complex are less well characterized: Exo70 is expressed in several tissues and is thought to also be involved in exocytosis.
Links
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Statistics
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PSSM-Id: 367324
Aligned: 272 rows
Threshold Bit Score: 128.928
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2B1E_A                   179 GMNSYTEALLgFIANEKSLVDDLYsqy-----teSKPHVLSQILSPLISAYAKLFGANLKivr-----snlENFGFFSF- 247 bak...
WGS:AAFB:cds.EHI_142040A 274 afittMKHVLsLFQNERIFQQDILq--------nDFDKFFVGTTDEPFTAFIDLYTSFVStlq-----tldTPFIVFPLl 340 Ent...
Q558Z9                   439 PLISYVQETLrLYQIEYDLASELF------------GNQYQLILDEIIDPAHELLLETTEpiikvrktpgdKIFSIFPLl 506 Dic...
EGC34417                 424 PLISYVSETLrLYQIESDLASEFF------------GNQYHTILEEIIDPAHELLLETTEpiikvkktpgdKVFSIFPLl 491 Dic...
EXX51093                 238 GFNSYTDAILkMFKTEYEIAEKILps-------eSVMPGYRDTIQIPLDNYVETGRTLTNrik-----knmQTDVFLAF- 304 Rhi...
EPB82934                 215 EFLKYTECYTkMLESEYKFAQQIMgn------eqRRAAALKGSIVPATVEYIAAGKQLNAvak-----rlnYTETTFVF- 282 Muc...
KDE06783                 253 SLGRFLDVMFgLLKSEYALLSTVFanv----ppsTRREIYSNILPPSLSLFYTTGTQLNGvvkka--ldalVPIAFSTFs 326 Mic...
XP_016270587             277 GLGRVLDVMLaLAKSEHALLGTVFasl----pasQRTSLYSSLLRPSLTLLTNTGQSLNSlikks-ahyalVPIAFATFq 351 Rho...
KIS70687                 296 GAVELFEAYYgMLDNDYRILQGLMtsaeldkqtlLLASTFSQLASQPLTALIESLGTVQShvr------rhlATHTSFLl 369 Ust...
XP_024512231             295 nimsiwEAIMhAAEGETMLAESLFpn-------hPPQTILTQTLASPITLANKALSPTLStlk------kylSRHTFTAl 361 Cry...

2B1E_A                   248 ELVESINDVKKS---------------------------LRgke--------------------------lqnYNLLQDC 274 bak...
WGS:AAFB:cds.EHI_142040A 341 DILEVYENMKADftnalkinedpknkskgfialekgfnvLTssftfgsdkkeddeeeddlyvedttgdkrdsqTKRVDAL 420 Ent...
Q558Z9                   507 DLFDTFTKLLPD---------------------------FItaiss----------------------rdgkhISELKTQ 537 Dic...
EGC34417                 492 DLFDTFTTLLPD---------------------------FIssisa----------------------rdgkhISELKTQ 522 Dic...
EXX51093                 305 DMMESLNKNVGS---------------------------FEevfrl-----------------------agkkDSAYNEL 334 Rhi...
EPB82934                 283 DIIEKFDRECISyv-----------------------eeLShiv----------------------------slHDIQDM 311 Muc...
KDE06783                 327 ELQEQIAEFEEW---------------------------VRika--------------------------arkDNELGEL 353 Mic...
XP_016270587             352 ELQERQGEFEDW---------------------------VRtka--------------------------grkENEVGDL 378 Rho...
KIS70687                 370 DLIGALSGIVLTgrw----------------------dvLLramedspeaplhsts--pidraeldlntgfapAAEVLEI 425 Ust...
XP_024512231             362 DLYASVSRLLPQ---------------------------WDhimssclsrlg-----------tpqspattelVTALDQS 403 Cry...

2B1E_A                   275 TQEVRQVTQSLFRDAIDRIIKKan-------siSTIPSNNGVTEATVDTMSRLRKFSEYKNGCLGAMDNITRENWLpsny 347 bak...
WGS:AAFB:cds.EHI_142040A 421 FDTMYTNVKTLLIKFRDEVLIDstlnkifswteSSIPVDGTVSQLAADTMHYLSKLEKYLPQLSSYISRMYREE------ 494 Ent...
Q558Z9                   538 IKHLQDTCASLLDFSLDEEKEIsss------nrKEIISDATVDEISSNMINYFKRLIEYKHSVELLLKGQDNNNSNsnsn 611 Dic...
EGC34417                 523 IKHLQETCASLLDFSLEDDREQrs--------kDSVITDATVDEISSNMLNYFKRLIEYKSSVELLLKSQQSASSS---- 590 Dic...
EXX51093                 335 LYSLRAVALCSFPEFIDEIKNNra-------ktMNIPSDGTIHELTITTLQHLKRLTDYQETVETMLLTLGDGNWNssek 407 Rhi...
EPB82934                 312 INSFKLTVLRNFYEFMEDVRGRkev-----sqpTNLSSDGTVHEMTSNTLNYFKRLYIWRDTVEPLLVLIGDGGWNnmps 386 Muc...
KDE06783                 354 LHAFRGTCLTSLPAMIDTTKQWgar------giSASESGAGVGTVTFNVVNFMRQLSDNQTVVEGFLNVLGPGNWGgp-- 425 Mic...
XP_016270587             379 THAFRGTCLTSLPGIIEETKSWgnk-----apvGTEALSAAVSPVTINVVNFMRQLTDSQATAETFLGVLGAGNWGg--- 450 Rho...
KIS70687                 426 YSKLKNTAIGIFPRFIEDVKAIpar------kvSEVP-STSVNEITYLGLQFIRQITEYSDVVSPLLHTLGNGNWMmssg 498 Ust...
XP_024512231             404 VNTLRSLSLRSFPEMLVDVRSAt----------TEGPPTSVISDITYSTITYLESLMEYEQVVEGLLGKSKSERSWlmg- 472 Cry...

2B1E_A                   348 k------------ekeytLQNEALNWEDHNVLLSCFISDCIDTLAVNLERKAQialmpnqepdvanpnssKn-------- 407 bak...
WGS:AAFB:cds.EHI_142040A 495 -------------------NKQNSNGTEDEGYVGMFVDVCIQNLCQMIEARAS-----------------K--------- 529 Ent...
Q558Z9                   612 apsstssnskssssssssSSSNSASSTILPTSFIGFLEKILKNLIKYLQGRAK-----------------Kdfptqpatd 674 Dic...
EGC34417                 591 ------------------SSSSSSSSSSSSQTFYTFLEKILKSLIKYLQTRAK-----------------Kdfssqpatd 635 Dic...
EXX51093                 408 --------------danfSRDKTGRGVSGNVVIQHYFADVLESLSNTLDSRSK-----------------Sy-------- 448 Rhi...
EPB82934                 387 pqim-------ndtsriqQGESAIGAA----LLQKFFVDALDQMTVALQLKSR-----------------Gy-------- 430 Muc...
KDE06783                 426 -----------------kIPVSTRDGDEEQSLLTRYLNDVLQTLLAALDQRAK-----------------Gl-------- 463 Mic...
XP_016270587             451 -----------------pSKTSAATGGDENGLLSRYLNDVLSVLLSSLDSRSR-----------------Il-------- 488 Rho...
KIS70687                 499 --------------vapiLSLGLDSDASKQSIVGDYLNDVVAVVLTSLEARSR-----------------Ai-------- 539 Ust...
XP_024512231             473 ---------------lneLPSNVRSADEEGGIVKFFVADVLGTLLNHLHAKAK-----------------G--------- 511 Cry...

2B1E_A                   408 --KHKQRIGFFILMNLTLVE--------QIV--------------EKS-ELNLMl--AGEGHSRLERL-KKRYI-SYmV- 457 bak...
WGS:AAFB:cds.EHI_142040A 530 --EKSRLGKIFKINNYAFIMnvcmldgfEKL--------------FGS-SLQKKi--ESDFTTKKENA-IHEYKdSLq-- 587 Ent...
Q558Z9                   675 ffKPPIKSVIFQINNYHYIS--------TSL--------------KQS----KIl--SNQQFENNELAsANHILhEFeTc 726 Dic...
EGC34417                 636 ffKPPIKSVIFLINNYRYIA--------SSL--------------KQS----NIlgdSENVNNNNNNA----ILhEFeTc 685 Dic...
EXX51093                 449 --KKTALTCIFLLNNYHHIL--------KSV---------------RS-QFYSVl--DPDIERKYEKM-VKKYNdGY-Q- 497 Rhi...
EPB82934                 431 --KKQTLATLFLLNNYNHIL--------RQI---------------RSpPLNAIf--DDGSEMKFGKL-VKKQLdAY-Q- 480 Muc...
KDE06783                 464 -rARSGISAIFLLNNISFIR--------REV--------------LSS-QIGDVl--GEACEDALNKL-MRTTKaSY-L- 514 Mic...
XP_016270587             489 -rGRSGTGAIFLLNNVSFVR--------HAV--------------LST-AIIDVl--GEAAEDSLNKR-MRTTKaSY-L- 539 Rho...
KIS70687                 540 --RQPSTASVFLLNNIGHLR--------RSVsaplpsylgaaedgSSVsIISLHl--GEMGNDLLGTA-LRQANtSYl-- 604 Ust...
XP_024512231             512 --MKRPIGQAFLLNNVSHIR--------NML--------------IIQ-SNSDIt--GPGAEAMLNKA-VRDARtQF-I- 561 Cry...

2B1E_A                   458 ---------SDWRDLTANLMDSVFID------------SSGK-Ksk-----dKEQIKEKFRKFNEGFEDlVSKTKQYKL- 509 bak...
WGS:AAFB:cds.EHI_142040A 588 -------------SIYETLNArp---------------------------skSEQIKKAFTSFNKDFQAlHTVSSGYSV- 626 Ent...
Q558Z9                   727 ldneikvlnSFWKTIADILITN---------------------KsnkekdevKSIIKKH-TNFLKTFNDlNKLKFDI--- 781 Dic...
EGC34417                 686 ldnetkvfnSFWKTITDILVIT---------------------KtgkdkddtKAVIKKH-TNFLKTLNDlNKLKFDI--- 740 Dic...
EXX51093                 498 ---------DTWKPCFSNLMDTTWVRgg---------sALKAlGsn-----eKSIVKEKFKNFNTEFEEtYKVHKSYAI- 553 Rhi...
EPB82934                 481 ---------ESWKPCVENLMDVTYVRgg---------aIKSSmGsq-----eRQLIKERFKNFNTEFEEiARAQQTYAI- 536 Muc...
KDE06783                 515 ---------EIWSPLVSALLDAGLEQsgaag--aikaaVKGGgGgg----neRAQTKDRFLRFGDGLQEvENLHAVAKLd 579 Mic...
XP_016270587             540 ---------EIWSPLVSALLDAGFAEqsgaagalkaglGAVTgGgg----teRRETKDRFVRFHEALEEvEQLHQQAKLd 606 Rho...
KIS70687                 605 ---------DAWSPVVAPLMDDQPLNatqyh--rhatsKLIGvGsg----seKNQVKDRFARFYEALEDlERLHRAYPVn 669 Ust...
XP_024512231             562 ---------SEFQSLTSLLTSAPHSH------------TQRFaVpqlp-tseRHNLKESSIAFFERLGElEGVMARYPLn 619 Cry...

2B1E_A                   510 -SDPSLKVTLKSEIISLVMPMYERFYSRYK--DSFKNPRKHIK-YTPDELTTVLNQ 561 baker's yeast
WGS:AAFB:cds.EHI_142040A 627 -YNDQLKEELRSVLKEQILEPYTLFYNNYEkvKFTQNPTKYFL-YTPQMVEQCIKl 680 Entamoeba histolytica HM-1:...
Q558Z9                   782 -PDQELKLKLKTEAKNIIGRSYDQFKELcrle-kihlEKNFVPfETTDDINRKLDR 835 Dictyostelium discoideum
EGC34417                 741 -PDLELKQKLKTDSKNIISKSYDNFKEAcrle-kihlEKNFTPfETTDDINRKIEk 794 Dictyostelium purpureum
EXX51093                 554 -PDPDLRIQVIKDIKIVLMPVYNRFLEKYQqtEFSKNPTKYIR-YDPQTLENMVNR 607 Rhizophagus irregularis DAO...
EPB82934                 537 -PDTELRNQVIRDVKNVLVPMYGRFLDKYQntDFTKNPAKYIR-YDKDKVDRMISH 590 Mucor circinelloides f. cir...
KDE06783                 580 eGEQELKERLKGEVERMIVPTYTKFLAKHRngDFSKNPEKYLK-LDADQLEARIQa 634 Microbotryum lychnidis-dioi...
XP_016270587             607 dGDVELKERLRDEVDRMVAPTYAKFVQRHRkdNY---STKYVR-LDADGLEAKIRt 658 Rhodotorula toruloides NP11
KIS70687                 670 rEDHELKERLTRDVTRLVCPMYARFLAKHKasDFTKNPSKHIR-MTEQEVEDKIAS 724 Ustilago maydis 521
XP_024512231             620 rQDPEMRDSVGREVEGVVRKGYEAFAARCQ----SKGAEKYVR-SSPDEVSRRVQS 670 Cryptococcus neoformans var...
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