Conserved Protein Domain Family
HSR

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pfam03172: HSR (this model, PSSM-Id:367372 is obsolete and has been replaced by 397335)
HSR domain
The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.
Statistics
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PSSM-Id: 367372
View PSSM: pfam03172
Aligned: 61 rows
Threshold Bit Score: 103.369
Threshold Setting Gi: 1174697597
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELW71234       5 LEAALFQHFSHQKLEIAYAIDKPFPFFEGLWDKSFISDRQYGESMEACrNLVPIAKVVHS-----------TLTQLETRF 73  Chinese tree shrew
XP_683309     11 TDEQLLSVFHLKKTEIS-CIEQPLIFLTQLRDHNLLPETRFKKVKGMR-TREQRQQGVYD-----------VLEWLERER 77  zebrafish
XP_015216561   8 EDADLRSQLRMLRTEIAMAIDDPFPLLYGLADHDIITEQLFKDTLDKKk-HEGIHKAVYS-----------LLSRLLEKE 75  spotted gar
XP_014348180   8 CDADFRQILKMNRTEISMAVDDTFPFLHGLLDHDVVTEEMFKETLNMK-EREGSHKAVYF-----------LLTWLLKRD 75  coelacanth
XP_007667882   5 LEKQLLIKFREKKLAISDAVNKLFPFIYSLRDQALISNRMLQHYKN---ESVPMKERIYN-----------VLEKLEKNF 70  platypus
XP_023820721   8 kELNLRALLRELRTDIAMAVDDPFPLVYGLADKNIITEQLLKETLAKErT-EGIHKAMYS-----------MLSWVLERS 75  Japanese medaka
XP_009296781   8 EESDLRSQLRACRTEIAMAIHDPFPLLYGLADHNVISEQILRETLERKk-KDGIHKAIYSlltllldqdttVL------- 79  zebrafish
XP_013124273  25 RDTNLRSLLRELRTDIAMAVDDPFPLVYGLADKNIITEQLLKETLEKE-AREGIHKAMYS-----------LLSWVLEQS 92  Nile tilapia
CAG07656       5 GETNLRSLLKHLRTDIAMAVDDSFPLVYGLADKNIITDQLQKDTLEKE-SREGIHKAMYS-----------LLSWVLQQR 72  spotted green p...
XP_020561094   8 ESAQLQQFFHSRKTELS-CLENPQTFLSQLRDYNLIPEDRYKKVIKMK-SKDRRRMAIYE-----------FLDWMERER 74  Japanese medaka
ELW71234      74 SV---PL---LKTLFSRINLVEYPKLNTICQSFRNG 103 Chinese tree shrew
XP_683309     78 SQ---DIrrfWRCVFEDHIVQKYPTLHLLRKSLPET 110 zebrafish
XP_015216561  76 TL---TIqnfWSNLFKDYNLERYPKLQSVFTSFPKD 108 spotted gar
XP_014348180  76 QSilqDF---WKISFKEYNLERYPKLKPVYNSFPKD 108 coelacanth
XP_007667882  71 NK---KV---LKVLFSRNNVKEYPDLKRIRRTFEDV 100 platypus
XP_023820721  76 KStiqSF---WSNLSKDYNTESYPKLQTLLANLHSr 108 Japanese medaka
XP_009296781  80 -K---AF---WKNLCKEYNKECYPKLETVFMNLPKG 108 zebrafish
XP_013124273  93 RS---TVqafLNNLSKDYNLDSYPRLQTLLTNLDCR 125 Nile tilapia
CAG07656      73 RS---VIrafWSNLFKDYNLDSYPKLQKLITNLPSG 105 spotted green pufferfish
XP_020561094  75 SE---HIplfWRCVFKEIILSQYPIFRLMRNSLMDG 107 Japanese medaka
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