Conserved Protein Domain Family
CD20

?
pfam04103: CD20 (this model, PSSM-Id:367814 is obsolete and has been replaced by 397979)
CD20-like family
This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.
Statistics
?
PSSM-Id: 367814
View PSSM: pfam04103
Aligned: 41 rows
Threshold Bit Score: 48.7921
Threshold Setting Gi: 75045739
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
P19437        44 ALGAV---QIMNGLFHITLGGLLMIPTGVfapICLSVWYPLWGGIMYIISGSLLaAAAEKTSR--KSLVKAKVIMSSLSL 118 house mouse
4_pfamImport   1 -VALL---QLLLGVAVTVVAFLMLAISPS----LLARETPHWAGIILCLVSVLG-FILYCITYlpDERTSAQFICEVLYF 71 
Q95PZ5        94 RLCLV---ELMLAVVILGGGIWCYRDTSD----YCPYYSAIWTSAIYIINAIVG-SAAAKMGA--LNLYMAHLTLSLVSV 163 Caenorhabditis ...
EDO34181       7 LLGIIssfHLVFGVFSVVLGIVTFKVAPY---FYGVFGMGIWLGAWMLITGVAGlLTASVPTN--MCRLGSFIGCSLVGL 81  starlet sea ane...
Q5HZJ5        36 TLGLA---QVLLGILVITFSMVASSVTTT---ESIKRSCPSWAGFSLAFSGLVG-IVSWKRPF--TLVISFFSLLSVLCV 106 house mouse
Q0V9M1        36 SLGVS---QMVLGCLIVAVSFAALALTTS---ARVRHSCPFWAGFSVLLSGLIG-VVAWKRPL--SLVITFFMLLSAVCV 106 tropical clawed...
EDO41456      20 GFGVV---QVILGLSLTGLSFAAFALSES---DRIRNACPYWAGFTVFFSGGVG-IVAWRHST--ILSMGLFTFFSAVCV 90  starlet sea ane...
1_pfamImport   1 SLGLL---QLILGCCTVALSFGALSLSKS---PQIRSSCPFWAGSSVILSGIVG-LTTWKRPM--VLLVNLFVMLSVVCV 71 
Q5BLA7        16 VLGIL---QVACAGLCVVCGFMDAVFRKSt--TLSETRAPLWAGLIMAAPGVLA-LFASQKKN--PYLVNVMIVSSVVSL 87  zebrafish
OCA48596      16 VLGIL---QIACAGISIVSGFMDGAFRREs--TLGRTRAPLWAGLIMTIPGVLA-LFSSQKKN--PVLVNALIAASVFSC 87  tropical clawed...
P19437       119 FAAISGIILSIMDILNMTLSHFLkmrrleliqtsk--pyvdiydcepsNSSEKNSPSTQYCNSIqsvFLGILSAMLISAF 196 house mouse
4_pfamImport  72 ILCSIGLVLSVLVVAFAGHHYSQasgfscgp----------argdcvcTLSQEDPIARTFTYEGvgdCQAITGTLTLYFL 141
Q95PZ5       164 MMCLISGGLSARNWALVGTYHHPridrdeafcll----gthdtsrisyIFSHMDKYDFAKCLWQlkvGVAVNSVQFVIAA 239 Caenorhabditis ...
EDO34181      82 VTLFVCAIIIGLGVLQHFKFESSinreyyi-----------akgpnyhKEYSRPQEHFDERNQNgenGVGIYGTLLALIV 150 starlet sea ane...
Q5HZJ5       107 MLSMAGSVLSCKNAQLARDFRECsmegkvcvccp----piplhrpcpeWGQELKVALNSTCDEArgaLKNLLFSVCGLTI 182 house mouse
Q0V9M1       107 MLNLAGSILSCQNAQLVSSLEGCqlinfnsdgvcvccemqhqtsgcsnPGETLKLNPLQECSAVrltLKDLLFSVCALNI 186 tropical clawed...
EDO41456      91 VLHMIGTILTGEVGGLLKSVLECqfsevdqsci-----ccdsimtckqSVPSYKFEGVDDCDILtglLKELMYGLCVLNI 165 starlet sea ane...
1_pfamImport  72 LLNLAGFILGCQGAQFVSSVPSCqlvemnegkvcv-cceeiyankcleRENFLKLFPVQSCNAVhllLKKVFFALCALNA 150
Q5BLA7        88 FAVVIVFVYACVTLSYGEEDDEI-------------------------FHAHPVPEVRFVLSRM---VKGANCTLLVACT 139 zebrafish
OCA48596      88 FTTLIVIVYASLTLGYGEDDDDIf------------------------SSPPHVIHARFILGKL---VQGANIAMLIASV 140 tropical clawed...
P19437       197 FQKLVTAGIVENEW 210 house mouse
4_pfamImport 142 VQIVLNLAQALVC- 154
Q95PZ5       240 IEVFLNILSAILCM 253 Caenorhabditis elegans
EDO34181     151 MDVIVNLVTMAVCK 164 starlet sea anemone
Q5HZJ5       183 CAAIICTLSAIVCC 196 house mouse
Q0V9M1       187 ISTIVCALATAMCC 200 tropical clawed frog
EDO41456     166 FGSLVCFIATILGC 179 starlet sea anemone
1_pfamImport 151 LTTTVCLVAAALR- 163
Q5BLA7       140 GSLLFSSLIAYIGC 153 zebrafish
OCA48596     141 SSLCVALCIAYMGC 154 tropical clawed frog
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap