2ZME,2ZME,1U5T,1W7P


Conserved Protein Domain Family
EAP30
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pfam04157: EAP30 (this model, PSSM-Id:367847 is obsolete and has been replaced by 461201)
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EAP30/Vps36 family
This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.
Links
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Statistics
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PSSM-Id: 367847
Aligned: 231 rows
Threshold Bit Score: 69.5846
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2ZME_A     6 VGAGAIaKKKLAEAKYKERgtvLAEDQLAQMSKQLDMFKTnLEEFASKHKQEIRKNPEFRVQFQD---MCATIGVdplaS 82  human
CCH62146 306 TGISTLeQSRETQLARNDI---LLNNALSDLSNLMSFADD-IEKLYSRYNKNDIS------------------------S 357 Tetrapisispora blat...
CAR26586 335 IGITSLeKSGETQLLNNDI---IFNNALTDLNRLMSLAND-IEQLYTGISPKLL-------------------------G 385 Zygosaccharomyces r...
CCE73214 335 VGIHALeKISEVQRKQNEM---VLASSLEDLEQMMYRAQD-LISLSNIFGRLIEARQVvq-------gIVPPLKIkks-- 401 Millerozyma farinos...
ABN66562 316 AGIHGLvQLGEQQRKQNEI---ILSTSLVDLENLMFKSQD-LIKLSNSFTKFIIDKKHPRFSLPAstkLVPPLDIkka-- 389 Scheffersomyces sti...
EGW33166 112 GGIHALeMLDEQQRRQNEI---ILSSSLNDLEQLMFKYQD-LIKLSGSFNQFIKPNEHNKRVPTss-qAIPSLNLkhs-- 184 Spathaspora passali...
CCE43466 317 AGIHALeAFGEQQRKNNEK---ILGSSLDDLEQLMFKFED-LIKLSSSFKRLLVSKDDKTiy-----kNIPPLTIsrt-- 385 Candida parapsilosis
EER34716 321 AGIHALeQLEELQRKQNEI---ILSSSLDDLEQLMFKYQD-LIKLSTSFNKLVKQQPASItk-----pVIPALNIkkt-- 389 Candida tropicalis ...
EMG50831 299 VGIHALeQLGELQRKENER---ILSSSLDDLEQLMFKYQD-LLKLSTSFNKLVIKSQDNLnl-----pVIPALNIkkn-- 367 Candida maltosa Xu316
Q6BSQ4   319 GGIHGLeQIGEQQRKQNEL---VLSTSLEDLEQLMYKAQD-LIKLSCSFGKLVKTTPQNin------tIIPPLNIkkt-- 386 Debaryomyces hansenii

2ZME_A    83 GKgfwsem----------lgvgdFYYELGVQIIEVCLAL---KHRNG------GLITLEELHQQVLK-----GRGKfAQD 138 human
CCH62146 358 SKmnskqvpslivdrdkfynkniFIEEIAREIYEFATSEfkdEQQREg----cVMISLVDLYAMYNKa----MRIG-VGF 428 Tetrapisispora blat...
CAR26586 386 ERkegghkpslildrekfynkslFLDEIAREIYEFAISEfkaEKERLg----yVMVTLVDLYAMYNKc----MRIG-TGL 456 Zygosaccharomyces r...
CCE73214 402 --------------------sklYHQELSRHISEYLA--------NLqltkssSMVTVQEAFAFYNRylvstQGFG-TDL 452 Millerozyma farinos...
ABN66562 390 --------------------sslYHNELSRHISEYSV--------NYeltraaSMITSQELFANYNRylvltQGFG-ADL 440 Scheffersomyces sti...
EGW33166 185 -----------------------spqELSRHISEYLI--------NYeltttsSMITSQDLFANYNRflintQGFG-CDL 232 Spathaspora passali...
CCE43466 386 --------------------sklYHSELSRHMSEYLT--------SFvltkksSMITLPDLFAEYNRflvkcSGFG-TEL 436 Candida parapsilosis
EER34716 390 --------------------sslYHQELSRHISEFAI--------NYrltqktSMVSSQDLFAEYNRfliknQGFG-SEL 440 Candida tropicalis ...
EMG50831 368 --------------------sslYPQELSRHISEFLI--------NFiltqrtSMISSQDLFAEYNRflirnQGFG-TQL 418 Candida maltosa Xu316
Q6BSQ4   387 --------------------snlYHQELARHISEYLT--------NFqltkssSMITSQDLYAYYNRylvstQGFG-TDL 437 Debaryomyces hansenii

2ZME_A   139 VSQDDLIRAIKKLkaLGTGfgi--ipvGGTYLIQSvpaELNMDHTVVLQlae-----knG-------------------- 191 human
CCH62146 429 VSPLEMREACESFerLGLTklkltkinQRILCLGS---DNALE-IIKTKivqiieqfpgShllqisk------------- 491 Tetrapisispora blat...
CAR26586 457 ISPQEMREACERFeeLGLKdlkltkinGRVLCLAS---KNSFD-FVKTKildivnesagCdpllltq------------- 519 Zygosaccharomyces r...
CCE73214 453 VAAEDFGKAVELFdeLKLPfrlqhykkSDISVICY---RNSFDN--SKLirdmleeqerSfkynslkakllaqyqs--se 525 Millerozyma farinos...
ABN66562 441 VTPQDFNKAIEKFedLKLPirmkhyekSGLVVL-A---PRSKTGTYEENilaclrenenNfkynklrnqnlgl------- 509 Scheffersomyces sti...
EGW33166 233 IKAADFNKSLELFaqLNLPvtmrkyekSGLLVIAK---TKLLQESYGKYivnfikdqehEyklnkcrhdmmq-------- 301 Spathaspora passali...
CCE43466 437 VDIVDFRKSIDLFdtLNLPvvsnkyekSELVVI-R---PRVHANSYSEFiveflsqqehKykrsfirakmvdd------- 505 Candida parapsilosis
EER34716 441 ITSSDFQKAIDLFnaLNLPiivkkyvkSDIFVV-S---PRRNTNTYGEYivdylknqeyEyklmklrqemiee------- 509 Candida tropicalis ...
EMG50831 419 VTSSDFKKAIGLFdeLKLPvilkqytkSDIYVV-S---SRSTSNTYGEFivdylknqeyEykfmklkqematg------- 487 Candida maltosa Xu316
Q6BSQ4   438 IPHVDFNKSLNLFdsLKLPialknyerSGLIVICY---KRNNDY--SEFivnflrsqerLfthdkvkneilmsleeqead 512 Debaryomyces hansenii

2ZME_A   192 -------------YVTVSEIkasLKWETERARQVLEHLLKEGLAWLD 225 human
CCH62146 492 ------klneysqS----------DWTIGVITEVLQNCIDSGILVVD 522 Tetrapisispora blattae CBS 6284
CAR26586 520 ------llnrdssN----------AWTFAIITEVLQNCIDHGDIVID 550 Zygosaccharomyces rouxii
CCE73214 526 dsnywherfayfkGSTIPEIcnaLGWSYAITVEEIDTCVEAGLVVVD 572 Millerozyma farinosa CBS 7064
ABN66562 510 mdeflndeyryfqGNNISEIsdkFGWSYNITIEEIEKCIENGTVVID 556 Scheffersomyces stipitis CBS 6054
EGW33166 302 -gvivlehescfrGVTVGEIsstLNWSNNVTIEEVEICVNEGIIVVD 347 Spathaspora passalidarum NRRL Y-27907
CCE43466 506 gdndgldhengcyGATVSEIshaLNWSYNVTMEELDKSIDSGLVVLD 552 Candida parapsilosis
EER34716 510 sdmedalynavnyGKTISEIsnqFNWSYNITIEELDKCVEEGLIVID 556 Candida tropicalis MYA-3404
EMG50831 488 devmndlynaagyGKTVSEIstqFNWSYNITIEELDKCVEEGLVVID 534 Candida maltosa Xu316
Q6BSQ4   513 qdgyieenykffkGNTIPEIcdeLGWSYGITIEEIEKCIESGLVVID 559 Debaryomyces hansenii
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