Conserved Protein Domain Family
Glycogen_syn

?
pfam05693: Glycogen_syn (this model, PSSM-Id:368562 is obsolete and has been replaced by 399009)
Glycogen synthase
This family consists of the eukaryotic glycogen synthase proteins GYS1, GYS2 and GYS3. Glycogen synthase (GS) is the enzyme responsible for the synthesis of -1,4-linked glucose chains in glycogen. It is the rate limiting enzyme in the synthesis of the polysaccharide, and its activity is highly regulated through phosphorylation at multiple sites and also by allosteric effectors, mainly glucose 6-phosphate (G6P).
Statistics
?
PSSM-Id: 368562
Aligned: 6 rows
Threshold Bit Score: 1157.21
Created: 20-Mar-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
P23337  12 EVATEVTNRVGGIYSVLKSKAPVTVAQYGDNYTLLGPLNKATYESEVEKLDWEDESifpeellpIQKTLMSMREKGVNFV 91  Saccharomyces cerevis...
O93869  18 EVATEVAHRVGGIYSVLKSKAPVTTAEYGDRYTLIGPLNHQSAAVEVEELEPSNPE--------LKATIQAMRDRGIGIL 89  Neurospora crassa OR74A
Q8VCB3  32 EVSWEVTNKVGGICTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPTNDA--------VRKAVDAMNKHGCQVH 103 house mouse
P13807  31 EVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPA--------LKRTLDSMNSKGCKVY 102 human
Q9VFC8  53 EVAWEVANKVGGIYTVIRSKAYVSTEEMGEQLCMMGPYKEHCARTEMEEMEFPRGNp-------LLDAVNSLRSRGYKIH 125 fruit fly
Q9U2D9  48 ECAWEVANKVGGIYTVLRSKAQISTEELGDQYCMFGPMKDGKWRLEVDPIEPENRT--------IRAAMKRFQADGFRCM 119 Caenorhabditis elegans
P23337  92 YGNWLIEGAPRVILFELDSVRHFLNEWKADLWSLVGIPSPEHDHETNDAILLGYVVVWFLGEVSKLDS---------SHA 162 Saccharomyces cerevis...
O93869  90 YGRWLIEGAPRVLLFDTKTAYGYMNEWKTDLWNVASIPSPDNDEETNEAIVFGYLVAWFLGEFVCHEK---------RKA 160 Neurospora crassa OR74A
Q8VCB3 104 FGRWLIEGSPYVVLFDISSSAWNLDRWKGDFWEACGVGIPHHDREANDMLIFGSLTAWFLKEVTDHAD---------GKH 174 house mouse
P13807 103 FGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEe--------KPH 174 human
Q9VFC8 126 TGRWLVDGNPQLILFDIGSAAWKLDQFKSEMWEKCHIGIPHLDIETNDAIILGFMIAEFLEEFRNFAVtysqnnelsAPR 205 fruit fly
Q9U2D9 120 YGRWLIEGYPKVILFDLGSGAVKMNEWKHELFEQCKIGIPHEDIESNDAVILGFMVALFLKHFRESVTs-------yTPL 192 Caenorhabditis elegans
P23337 163 IIGHFHEWLAGVALPLCRKKRIDVVTIFTTHATLLGRYLCAAGdVDFYNNLQYFDVDQEAGKRGIYHRYCIERAAAHTAD 242 Saccharomyces cerevis...
O93869 161 VIAHFHEWLAGVALPLTKKRQIDVTTIFTTHATLLGRYLCAGS-VDFYNNLQWFDVDAEAGKRGIYHRYCIERAAAHSCD 239 Neurospora crassa OR74A
Q8VCB3 175 VIAQFHEWQAGTGLILSRARKLPIATVFTTHATLLGRYLCAAN-IDFYNQLDKFDIDKEAGERQIYHRYCMERASVHCAH 253 house mouse
P13807 175 VVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGA-VDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAH 253 human
Q9VFC8 206 IVAHFHEWQAGVGLIVLRTRLVEIATVFTTHATLLGRYLCAGN-TDFYNNLDKFAVDEEAGKRQIYHRYCLERGATHLAH 284 fruit fly
Q9U2D9 193 VVAHFHEWQAGVGLLMTRLWKLDIATVYTTHATLLGRHLCAGG-ADLYNNLDSFDLDAEAGKRKIYHQYCLERAACQTAH 271 Caenorhabditis elegans
P23337 243 VFTTVSQITALEAEHLLKRKPDGILPNGLNVVKFQAVHEFQNLHALKKDKINDFVRGHFHGCFDFDLDNTVYFFIAGRYE 322 Saccharomyces cerevis...
O93869 240 VFTTVSHITAYESEHLLKRKPDGVLPNGLNVTKFSAMHEFQNLHQQNKEKIHDFVRGHFYGHYDFEPENTLYFFTAGRYE 319 Neurospora crassa OR74A
Q8VCB3 254 VFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYE 333 house mouse
P13807 254 VFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYE 333 human
Q9VFC8 285 VFTTVSEITGYEAEHLLKRKPDIITPNGLNVKKFSAIHEFQNLHAVAKEKINEFVRGHFYGHIDFDLDKTLYFFIAGRYE 364 fruit fly
Q9U2D9 272 IFTTVSEITGLEAEHFLCRKPDVLTPNGLNVVKFAALHEFQNLHAQNKEKINQFIRGHFHGHLDFDLDKTLYFFTAGRYE 351 Caenorhabditis elegans
P23337 323 YKNKGADMFIESLARLNYRLKVSGS----KKTVVAFLIMPAKTNSFTVEALKSQAIVKSLENTVNEVTASIGKRIFEHTM 398 Saccharomyces cerevis...
O93869 320 FRNKGVDMFIESLARLNHRLKTAGS----KTTVVAFIIMPAQTTSLTVEALKGQAVIKSLRDTVDVIERGIGRRIFERSV 395 Neurospora crassa OR74A
Q8VCB3 334 FSNKGADIFLESLSRLNFLLRMHKS----NVTVVVFFIMPAKTNNFNVETLKGQAVRKQLWDTVHCLKEKFGKKLYDGLL 409 house mouse
P13807 334 FSNKGADVFLEALARLNYLLRVNGS----EQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLL 409 human
Q9VFC8 365 FGNKGADIFIEALARLNAMLKHEKP----DTTVVAFLIFPTKTNNFNVDSLRGHAVIKQLRDTINNVQQAVGKRMFDTCL 440 fruit fly
Q9U2D9 352 FSNKGGDMFIESLARLNHYLKTTSDprhmGVTVVAFLIYPAPANSFNVESLKGQAVTKQLKEAVDRIKEKVGQRIFDICL 431 Caenorhabditis elegans
P23337 399 RyphnGLes-eLPtNLDELLKSSEKVLLKKRVLALRRpyGELPPVVTHNMCDDANDPILNQIRHVRLFNDSSDRVKVIFH 477 Saccharomyces cerevis...
O93869 396 K----WHegdpLP-EEKELITSQDRVLLRRRLFAMKR--HTLPPIVTHNMLNDHEDPILNQIRRVQLFNHPSDRVKIVFH 468 Neurospora crassa OR74A
Q8VCB3 410 R----GE----IP-DMNSILDRDDLTIMKRAIFSTQR--QSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRADRVKVILH 478 house mouse
P13807 410 V----GS----LP-DMNKMLDKEDFTMMKRAIFATQR--QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFH 478 human
Q9VFC8 441 Q----GN----IP-NADDLLQKDDLVKIKRCMFAMQR--DSMPPVTTHNVADDWNDPVLSSIRRCHLFNSRHDRVKMVFH 509 fruit fly
Q9U2D9 432 Q----GH----LP-EPEELMSPADNILLKRCIMSLHN--SSLPPICTHNMI-RADDPVLESLRRTSLFNKPEDRVKVVFH 499 Caenorhabditis elegans
P23337 478 PEFLNANNPILGLDYDEFVRGCHLGVFPSYYEPWGYTPAECTVMGVPSITTNVSGFGAYMEDLIEtdQAKDYGIYIVDRR 557 Saccharomyces cerevis...
O93869 469 PEFLSSANPVLPLDYDDFVRGTHLGVFASYYEPWGYTPAECTVMGVPSITTNLSGFGCYMEELIE--NSSDYGIYIVDRR 546 Neurospora crassa OR74A
Q8VCB3 479 PEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFVQEHVA--DPTAYGIYIVDRR 556 house mouse
P13807 479 PEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIA--DPSAYGIYILDRR 556 human
Q9VFC8 510 PEFLTSTNPLFGIDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMEEHIS--DPKSYGIYIVDRR 587 fruit fly
Q9U2D9 500 PEFLSSVSPLIGLDYEDFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVSTNLSGFGCFMQEHVE--DHEQKGIYVIDRR 577 Caenorhabditis elegans
P23337 558 FKSPDESVEQLADYMEEFVNKTRRQRINQRNRTERLSDLLDWKRMGLEYVKARQLGLRRAYPEQF-KQLVGETISDANmn 636 Saccharomyces cerevis...
O93869 547 SKGVDDSVNQLTQYMFEFTQKSRRQRINQRNRTERLSDLLDWKRMGMEYVKARQLALRRAYPTSFnGEEEEDFIPGVE-- 624 Neurospora crassa OR74A
Q8VCB3 557 FRSPDDSCNQLTQFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKF-HLEPTSPPTTDG-- 633 house mouse
P13807 557 FRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHF-TYEPNEADAAQG-- 633 human
Q9VFC8 588 YIGLENSVQQLSSFMMEFSRLNRRQRIIQRNRTERLSDLLDWRTLGIYYRQARVKALQAVYPD-Y-VDELSLYGSKNN-- 663 fruit fly
Q9U2D9 578 HKAAEESVQELAQVMYDFCGQSRRQRIILRNSNEGLSALLDWQNLGVFYRDCRRLALERLHPD------VDKIMRDNE-- 649 Caenorhabditis elegans
P23337 637 tlaggkkFKIARPLSVPGSPkVRSnstVYMTPGDLGTLQDANNADDY 683 Saccharomyces cerevisiae S288C
O93869 625 -------QKISRPFSVPGSP-RDRt--GMMTPGDFASLQESHEGLST 661 Neurospora crassa OR74A
Q8VCB3 634 -------FKYPRPSSVPPSPs----------GSQASSPQCSDAEDEE 663 house mouse
P13807 634 -------YRYPRPASVPPSP----------SLSRHSSPHQSEDEEDP 663 human
Q9VFC8 664 -------LIFSRPHSEPPSP-TSS---RHTTP--APSVHGSDDEDSV 697 fruit fly
Q9U2D9 650 -------GKVPSAA-----------------TSRRPSIHSSDGEDDE 672 Caenorhabditis elegans
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap