1M1E


Conserved Protein Domain Family
ICAT
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pfam06384: ICAT (this model, PSSM-Id:368871 is obsolete and has been replaced by 399405)
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Beta-catenin-interacting protein ICAT
This family consists of several eukaryotic beta-catenin-interacting (ICAT) proteins. Beta-catenin is a multifunctional protein involved in both cell adhesion and transcriptional activation. Transcription mediated by the beta-catenin/Tcf complex is involved in embryological development and is upregulated in various cancers. ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions.
Links
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Statistics
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PSSM-Id: 368871
Aligned: 20 rows
Threshold Bit Score: 73.1073
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1M1E_B          1 MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLpphS-IDQgAE--DVVMAFSRSETE 77   human
XP_011270458  113 LQRDVKLGKLAEPDFQQQSVEILVALRNLGEQLSPAEVEFLNKHSSGSLNNFEKV---S-SDL-AG--DKVLSAAGSQVA 185  Capsaspora ow...
Q54ID4        113 IQRDVQLGKISKDAYIDQSVEILAALKKLDFVLSPEEEAFLEKHKSRSMSEFEKV---S-SNIgQGtkENILSSAASQIK 188  Dictyostelium...
EFA86633      113 IQRDVKLGKLSKDSYIDQSLEILVALKKLGFTLSPEEENFLEQHKSRSMSDFEKA---S-SNIaQGtqANILSSAATQIQ 188  Heterostelium...
EGG22527     1700 IQRDVKLAKISKDSYIDQSIEILYALKKLGFAISPEEENFLEQHKSRVMGDFEKV---S-GNIgQGtkDNLMSNAATQIQ 1775 Cavenderia fa...
EFX78975      110 IQRDLKLGKLSSQAAQTQQVEVLGALKGLGEVLSTEEANILEKTNSASLQQFIKV---S-TDPeSK--SKLLALAENsls 183  common water ...
XP_003963172  113 MDRDVIVGKLPRDVYTQQKMEILTALRKLGEKLTADDEAFLSENATATLSQFEKV---T-PNLgSE--DKIMALASSGVK 186  torafugu
Q28D79        113 LDRDLMVGKLGRDLYTQQKGEILIALQKLGEKLSPEDEAFLSENAGAVFNQFQKV---S-EGLgSG--DKVLALASIEVE 186  tropical claw...
EDO30486      113 MQRDLKTGHMGQSVYTQQAIEILMALKKLGEQLKPEETEFLAANSNAALSSFEKV---A-ENSgAG--ASLLKVAGSQVE 186  starlet sea a...
XP_003384318  113 MQRDAKMGKITEDTLTQQKVEILVALRKLGEKLTAEELDFLSAHSTAALSQFEKI---SdADTaAG--EKVLAIAGTQVK 187  Amphimedon qu...

1M1E_B         78 DR 79   human
XP_011270458  186 TA 187  Capsaspora owczarzaki ATCC 30864
Q54ID4        189 NA 190  Dictyostelium discoideum
EFA86633      189 KA 190  Heterostelium album PN500
EGG22527     1776 KA 1777 Cavenderia fasciculata
EFX78975      184 lq 185  common water flea
XP_003963172  187 Tk 188  torafugu
Q28D79        187 NT 188  tropical clawed frog
EDO30486      187 DA 188  starlet sea anemone
XP_003384318  188 k- 188  Amphimedon queenslandica
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