Conserved Protein Domain Family
Fez1

?
pfam06818: Fez1 (this model, PSSM-Id:369093 is obsolete and has been replaced by 462015)
Fez1
This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.
Statistics
?
PSSM-Id: 369093
Aligned: 44 rows
Threshold Bit Score: 162.814
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_017214089  390 TKWEVCQKSGEISLLKQQLKDLQADLAQRVGELVTVRGQLREVRSELQTSQNQLQEANTTSRTRILE------------- 456 zebrafish
EEN59695      318 TKWEMCQKSGEISLLKQQLKEAKSELSLKTNDVIASRGTIKDIKTELSEKDSQVTALQDKVSEKNAE------------- 384 Florida lancelet
12_pfamImport   1 -EWERQQKYGELSMLKSQLKDIQAESAQRGSEIVALRTRNRELQALVARRDAEAVDLNEKLNDRNLE------------- 66 
XP_016663121  295 TEWGLCQKSGELAHVKSQLKDTQNELTTKGHEVIALKSEIRDLLQKLESKERRIDEIEGRRPERLDSdnggdgnccddql 374 pea aphid
EEZ98911      308 TEWGLCQKTGEISLLKSQLKDYQNEQTAKCQELLQLRTEHRDFREQLDLREAEISELRHQSEEKDAE------------- 374 red flour beetle
OWR54544      125 TEWSLCQRAGEIALLKTQLKEAQNEQTAKGHEYLTLKSDCRQLREALDKKDKEILRLRAESEEKEKS------------- 191 Danaus plexipp...
9_pfamImport    1 TQWKVCQKSGEISLLKQQLRDSQAEVTQKLSELFQLKTQLRETRAELRDRDAQIDTLKLVLSSSQPA------------- 67 
XP_006006078  426 TKWEVCQKAGEISLLKQQLKDSQAEVSQKLNEIVGLRAQLKEAKALLRDKEEQVLNLKDSYSSKSID------------- 492 coelacanth
XP_004911381  385 TKWEVCQKAGEISLLKQQLKDCQADLSQKLNEIVGLRTQLKEAKAFLREKEEQIASIKDSYSSKSVS------------- 451 tropical clawe...
XP_021336943  268 TQWEVCQKSGEISLLKQQLRDSQAEVTQKLSEIFHLKTQLHETRNQMRSKDSQIDSLQTAV------------------- 328 zebrafish
XP_017214089  457 ------------LEVCQNELQR------------------------R------------KSENELLREKISHLEEDSSQM 488 zebrafish
EEN59695      385 ------------ILHYQDEVAK------------------------Q------------QCELDNLSDTLRKREDELMDL 416 Florida lancelet
12_pfamImport  67 ------------IGELEQRLSE------------------------AsspagtwhrspgSISPQSLRNPSGTFSEPNSGN 110
XP_016663121  375 aadklcslvgrlNEQVENELSK------------------------Snklls--ecystEDLHSLLPKKDTEADSPLERF 428 pea aphid
EEZ98911      375 ------------IKLLKEQLAR------------------------L------------GNKSPTIDD----LKEEIREL 402 red flour beetle
OWR54544      192 ------------MKKLQAEVER------------------------LnndlmnsvtdltKTKESNKKE-IEKLKTEVKEL 234 Danaus plexipp...
9_pfamImport   68 -----------------QEEAK------------------------AaeitgscliralTQTQPMTNQVRSSVVCTFKST 106
XP_006006078  493 ------------LEVCENELQR------------------------K------------MNEVQLLREKLNQYELEISGL 524 coelacanth
XP_004911381  452 ------------LEICENEMQRkqseaqqmkeklsqceqeisslkeA-----------------------------LASL 490 tropical clawe...
XP_021336943  329 ------------------QGAR------------------------R------------KCTMPAFED-----------T 343 zebrafish
XP_017214089  489 ----RD-ALNAAAS------------------------GKEQRLaeeteeLKTSRQQADRLKA----------------- 522 zebrafish
EEN59695      417 ----KD-SYRQVKedlsnvraeldnkikeeqlisqcdeVKERRKnkerdlIESLKVEVQRLRN----------------- 474 Florida lancelet
12_pfamImport 111 whddRN-YLSSSSPpg---------------------------------aLTSLKR--DELIK----------------- 137
XP_016663121  429 ----RE-----------------------------------------------LERHTAKLIR----------------- 440 pea aphid
EEZ98911      403 ----RE-ELSDMSLseygsve-----------------------pgrsqrISQEDLEIECSCS----------------- 437 red flour beetle
OWR54544      235 ----RQ-ELSDVSLsgyegiecgrtmrgi------ydvcktneyhwtssdSALEDAEVQRLNGelpdscsepcpagaivd 303 Danaus plexipp...
9_pfamImport  107 ----RRlSLRSTLRlcrpa--------------------------aeaiaGGCGGSTEERLRA----------------- 139
XP_006006078  525 ----KQ-GLANpghthtydgeld---klgnpltcesdeAKMKRQse--daVHGLKKQLERLQS----------------- 577 coelacanth
XP_004911381  491 ----GQnpytielnekl-----------rdtlacesdeAKMKRQne--dsVISLKKDIERLQL----------------- 536 tropical clawe...
XP_021336943  344 ----RS-DMDTg-------------------------------------eTGGSSATEERLRA----------------- 364 zebrafish
XP_017214089  523 ELAYERQRFSDQAAAFESERKSWEEEKDKVIRYQKQLQQNYVQMYKRNRDLERSL 577 zebrafish
EEN59695      475 ELKTVHQRHDAQLMEFERERAIWQEEKEKVIHYQKQLQLNYVQMFRKTKNLEKEV 529 Florida lancelet
12_pfamImport 138 RLYEAEARCNEQEKFFNIERRQWADDKSRVIRYQKQLQANYVQTYKRCGALEREV 192
XP_016663121  441 VLNEERKN-------WDQERLKWFQEKEKVLCYQRQLQMNYVQMFRRTQAFEAQI 488 pea aphid
EEZ98911      438 SLAKLKQEIASKTKDFENERVVWAQEKEKVLRYQRQLQMNYVQMYRRTRALEAEV 492 red flour beetle
OWR54544      304 RLKCEIQNKEQQ---FNNERRKWSDEKDKVLRYQKQLQMNYVQMFKRSRTLEAEI 355 Danaus plexippus plexippus
9_pfamImport  140 ELLLERRQSEAQAMAFDEERQTWQTEKEKVIRYQKELQASYLEMYHRSEALEREL 194
XP_006006078  578 ELRLERQQREQQVVGFEEERRTWQEEKDKVIKYQKQLQLNYVEMYQKNQLLEQQI 632 coelacanth
XP_004911381  537 ELTVEKQQRDQQVVDFEEERHTWQEEKEKVIKYQKQLQLNYVEMYQKNQQLEQRM 591 tropical clawed frog
XP_021336943  365 ELLLERRQNEAQTSAFESERKTWQNEKEKVIRYQKELQASYLEMYHQNEALEREL 419 zebrafish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap