Conserved Protein Domain Family
Elongin_A

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pfam06881: Elongin_A (this model, PSSM-Id:369120 is obsolete and has been replaced by 399694)
RNA polymerase II transcription factor SIII (Elongin) subunit A
This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.
Statistics
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PSSM-Id: 369120
View PSSM: pfam06881
Aligned: 115 rows
Threshold Bit Score: 76.0796
Threshold Setting Gi: 328871862
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGG12725      22 DVGNCVYELIRPVLFACPPDQLAEIEDLSPHLMLESDEIWLLHL------RRDFPNESK-PQATRtiepepnsepyptqt 94  Melampsora lari...
EJT41812      21 SVSNVPYHLLKKILQKVKIPQLLRLEKSNVLLVFDDDELWLEFL------KHDFPTNVQ-EQFVS--------------- 78  Saccharomyces k...
CCC71021      21 DIGCTPFRLIEDVLDKMNKEQLIRLEEKNVFLVLEDDKIWLKFL------KLDFPTSVHvSYVSRk-------------- 80  Naumovozyma cas...
Q16S30       485 YTGGIPFDLLKPVLERASPEQLFTLESYNPYLMEDSDVLWEQHI------KRNFRSQKRkEEECEs-------------- 544 yellow fever mo...
5_pfamImport   3 EIGKVPYTVLEPVLEKCTPKQLHRIEGYNHFLIGDTDQLWKNHC------NRDFKKERP-KESEs--------------- 60 
CDS42112     273 SVGEVPYELFSRALHDASPEDLLRIEKHNPKFRGLMDDLWKKHV------YRCFPESRNlDGIRPk-------------- 332 Echinococcus mu...
EPB81267      25 EVGCVPYSLLKNSLVHATPQQLYKIEKANPDIAAESDELWLKHCltytdiREDYYQHGLyRDSTk--------------- 89  Mucor circinell...
XP_001091087 546 DVEGIPYWYLEPVLEGWTPDQLYRREKYNHALAGDTDELWRIHC------LQDFKEG-K-PQEQEs-------------- 603 Rhesus monkey
XP_024897175 380 EVGGVPYSVLEPVLERCTPEQLYRIEEYNHVLIEETDQLWKVHC------HRDFKEE-R-PEEYEs-------------- 437 black flying fox
OCA45408      94 EVGGVPFSVLEPVLEKCTPDQLYRIEECNHVLVEDTDRLWMNHC------QRDFKKDKP-DEYEs--------------- 151 tropical clawed...
EGG12725      95 inpyTNEPidlpihRIQYFTIKQSKAKALANASARLRERTQANRSEFSKRKA 146 Melampsora larici-populina 98AG31
EJT41812      79 -----RRDs----iCKYYFNFIMENDIELYQSDQDLLKSCIRQSVVKDTRnn 121 Saccharomyces kudriavzevii IFO 1802
CCC71021      81 ----Ei-------iYNQYLDFIRKFDEILLNERRQLVSIYLKALVNKDPKKm 121 Naumovozyma castellii CBS 4309
Q16S30       545 -------------wREMFIRCSEERESKLLSLTANIKQSQVEKTAPIRKTQL 583 yellow fever mosquito
5_pfamImport  61 -------------wRELYLRLQEAREQRLLVLTENIRSAHANKPKGRQTMMA 99 
CDS42112     333 ----Et-------wAKMYVRLEAENSRRLKQF---IKCSSIKQQAERETRRT 370 Echinococcus multilocularis
EPB81267      90 -------------wRELYLNRYKETERKRQLIKQKVKSQYSKIQNEKEKRSI 128 Mucor circinelloides f. circinelloides 1006PhL
XP_001091087 604 -------------wRELCLRLQDTREQRLRVLTANIRSARENNPNSREAKMI 642 Rhesus monkey
XP_024897175 438 -------------wREMYLRLQDAREQRLRVLTKNIRSAHANKPKGRQAKMA 476 black flying fox
OCA45408     152 -------------wRELYLRLHEAREQRLLMLTQNIRSAHANKPKGRQAKMA 190 tropical clawed frog
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