5Z2Q


Conserved Protein Domain Family
Vg_Tdu
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pfam07545: Vg_Tdu (this model, PSSM-Id:369418 is obsolete and has been replaced by 462203)
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Vestigial/Tondu family
The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Scalloped (Sd) interacts with Vestigial (Vg) to form a complex, which binds DNA through the Sd TEA/ATTS domain. The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wing outgrowth when ectopically expressed. This short conserved region is needed for interaction with Sd.
Links
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Statistics
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PSSM-Id: 369418
Aligned: 17 rows
Threshold Bit Score: 53.1643
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5Z2Q_C        16 TEWNAGSVIFTYFEGDINSMVDEHFSRALRN 46  house mouse
EEC17208     100 QYLSANCVVFTYYSGDISSVVDEHFSRALSQ 130 black-legged tick
EFV51452      33 QYLSANCVLLTYTDGDLAGQLDEHFTKSLSg 63  Trichinella spiralis
EGI65981      94 QYVNANCVVFTHYRGDAASEVEEHFQRALAH 124 Panamanian leafcutter ant
Q26366       282 QYLSASCVVFTNYSGDTASQVDEHFSRALNY 312 fruit fly
EFX86704     238 QYISANCVVFMSYSGDTASVVDQHFSRALNa 268 common water flea
Q8BGW8        78 EYINSRCVLFTYFQGDISSVVDEHFSRALSH 108 house mouse
XP_002128412 108 hHISSRCVMFNYFDGETSNEVDEHFTRALNH 138 vase tunicate
XP_002128438  42 EYIRSRCYLVTYFKGHPRDKVDEHFNRSLRH 72  vase tunicate
XP_011681060 149 dYVNSHCVIFTFYSGDLDKIVDEHFSRSLSH 179 purple sea urchin
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