Conserved Protein Domain Family
TAT_ubiq
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pfam07706: TAT_ubiq (this model, PSSM-Id:369474 is obsolete and has been replaced by 462236)
Aminotransferase ubiquitination site
This segment contains a probable site of ubiquitination that ensures rapid degradation of tyrosine aminotransferase in rats. The half life of the enzyme in vivo is about 2-4 hours. In addition, unpublished information identifies at least 2 phosphorylation sites including CAPK at Ser29 and, at the other end of the protein, a casein kinase II site at S*QEECDK. This region of TAT is probably primarily related to regulatory events. Most other transaminases are much more stable and are not phosphorylated.
Links
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Statistics
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PSSM-Id: 369474
Aligned: 25 rows
Threshold Bit Score: 26.5844
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003439428     7 TKSYMVQMNGNG-----------VCGKTTVngktlnengvnrngvhgngvhhvnikgalyPTKSKSRRQR 65   Nile tilapia
XP_003967041     3 NKAYLVQMNGNG-----------VHGKNPVnsktpngtgvtgs-----glhrlsgngslyPTKVKSRRLR 56   torafugu
10_pfamImport    1 NKAYLVQMNGNG-----------VHGKNPVnsktp-----------------------ngtgKVKSRRLR 36  
ETE68168         1 MDSCLIQVNSNTtlssvldvhvnLNGKSPS------------------------------LPKGKGRKPh 40   king cobra
EGW04128         1 MDSYVIQTDDNGslpsvldvhvnIGGRSSV------------------------------QGKMKGRRAR 40   Chinese hamster
XP_003227448     1 MDSYLIQVTGKSafpsvmdvqlgRAGRGPC------------------------------CVAGKGKGHR 40   green anole
XP_021264684     1 MDSYLIQVNGQGdhvplldihlkSNGNSMS------------------------------LGKVKGRKPR 40   helmeted guineafowl
XP_026653414     1 MDSYLIQVNGHGdhapvldvhlkNTGNTIS------------------------------PGKVKGRKPR 40   white-throated sparrow
CAF98918         3 NQAYVVQMNGNA-----------VHGKGPAkcptpngtrvtgn-----gmhrvgangslyPAKGKSRRLG 56   spotted green pufferfish
XP_001367424     1 MDSYVIQMNGNGdlssvldvhvnINGRNTV------------------------------SGKMKGRKAR 40   gray short-tailed opossum
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