Conserved Protein Domain Family
Peptidase_S64

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pfam08192: Peptidase_S64 
Peptidase family S64
This family of fungal proteins is involved in the processing of membrane bound transcription factor Stp1. The processing causes the signalling domain of Stp1 to be passed to the nucleus where several permease genes are induced. The permeases are important for uptake of amino acids, and processing of tp1 only occurs in an amino acid-rich environment. This family is predicted to be distantly related to the trypsin family (MEROPS:S1) and to have a typical trypsin-like catalytic triad.
Statistics
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PSSM-Id: 369740
Aligned: 20 rows
Threshold Bit Score: 840.844
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001383587   4 MKRFLNRNRKsetsdre-------------sltsrnlAPTTSN----STTESHDesvnalqPMFDS---SHNDVGEAVPS 63 
CCK69361       2 AGKLFNIGRRtsrkd------------------kqdvQSSSDTpdaeSQGSSSRfgqgdgdSPnv---vNNPAGQIPEDT 60 
XP_011273138   1 MKRIFGIKKNdsn---------------------msnESVDETrkskEVGDDASdalpveiPIDMSidnSGPSLKGKEQE 59 
CCE42929       1 mKRFLSRTNKsdssdsnqdtdaaagqddtksrtssslRPSKSN----ISHESYDsvt-elrPMFGEakqSSSSSSSSSSS 75 
XP_001525183   4 IGRFSKSQGErdgegenqdv-------srkslenkglQPSRSN----HSGESQDslr-elrPIFGGqnaTTTAAAAATAA 71 
EMG48102       3 MKRFLSRSSRksstdkde-----------eipdntiiQPIASN----QSGESHDslk-dltPIFNS-----RQASSTTTT 61 
EER32686       3 MKRFLSRSSNkkttttgagetpp-ttagtsssftselVPTISN----HSGESHDsik-dlrPMFNQ----MREGQSSSAN 72 
Q5A341         3 MKRFLSRSSNkttagqgddt-------sasigsdlpiVPLPSN----QSGESHDsik-elgPMFRQ---QQNKQIADNDD 67  Candida albicans
Q6BY91         3 MKNLLNRTTKseykerdtpd--------aeeravldiKPVTSStmstSTEESQDsih-qlrPMFSSplaKAEDETKSNSQ 73  Debaryomyces ha...
EEQ38717       8 QKKesapa-------------------------skpeTPCASGaastTSVHSESdslkdlqPMFQH------------NS 50 
XP_001383587  64 SFHfnndmslnlnps---------isntnskqatsvFTKDSEYMDKSLFSrgQSRKTYSTKQSSYKSGTSNSSgk----- 129
CCK69361      61 AST------------------------------------RFSDKSSSIFS--RGRTANASSKNSSNMSGARSAsgsskk- 101
XP_011273138  60 SSEedd---------------------------pveSLLPSSYNRSSLFS--RDQNTFQTLSTNPTSSSSGgggsqgqg- 109
CCE42929      76 QHRpseagffdtglnlnps--ilgpsdtatvgasssRHSTVQREGNSLFS---SKQSFSTKQSSHQSANStkr------- 143
XP_001525183  72 ATAtaigmgmgmgmydsslnlnpsilnaplesvlqtSQASALKGGNSLFS---SKQSFSTKQSSYQNSAPHsk------- 141
EMG48102      62 SNMmmnlnlnptis------------natefskvaaSTKGSTIH-DSLFS--SRQSSYSTNPSSYASAGSGgg------- 119
EER32686      73 QYDmmhlnlnpt---------------isnttkvasSTKGSTIQ-ESVFS---SRQSYSTKQSSYQSDVSakr------- 126
Q5A341        68 SYDmmhlnlnpt---------------isnlnktvpSIKGSTIQ-DSLFS---SRQSYSTNQSSYKTGGTNTSggsssns 128 Candida albicans
Q6BY91        74 KFNfmhdtnlnlnp-----------silntnlapsvMTKDSEYMVNSMYS--DSKKTYSTKQSSYLTQNSqkktga---- 136 Debaryomyces ha...
EEQ38717      51 SAKfandpdlnln--------------pcisnsmsvGTSSASAGTRSVFS---SKYSSSTKQSSYMSSGSRakk------ 107
XP_001383587 130 -----keAFHYSQPLQILN----------IPEEANE-------------------------------------------- 150
CCK69361     102 --vfgntYNDLGKPLRVVTnsepfgtlstVLEEKSKadfakensaraa---------------------------mtsth 152
XP_011273138 110 kqsnvikIDNIGKPLRVLStdrynelsrvGTSTSQHstnssipssfnrrrrsdndynlssgqviplpmnpgsnvnnqsss 189
CCE42929     144 -----sfQYNYSQPLQILD-----------LEKTETgde----------------------------------------- 166
XP_001525183 142 -----ksFGDFGQALQTLN----------IVEGSTAske----------------------------------------- 165
EMG48102     120 -----ksYFSPSKPLQTLN----------VVKETDGddd----------------------------------------- 143
EER32686     127 -----klDFAPSQPLQILN----------ILEENEHq------------------------------------------- 148
Q5A341       129 qfgkrkhDLNTSQPLQTLK----------ILEENEHq------------------------------------------- 155 Candida albicans
Q6BY91       137 --ssaarNLEYGQPLQILN----------IAEESSEnp------------------------------------------ 162 Debaryomyces ha...
EEQ38717     108 -----nrASEYGQALQILE----------IPEETRYdan----------------------------------------- 131
XP_001383587 151 ------VNRTPYETIADKLCTLYDDLAYIMNQYNNSLINLTTAVINSIDCFKRF-------------------------- 198
CCK69361     153 eretssLPERAANSCQQELFHLETNLMELMDDVHQNVLNISKAIILAIEFFKDFlssgr--------------------- 211
XP_011273138 190 sggtggLNILTQEIVSKELSILNENLLGLIDQLNQNVINISKATISIVEFLDDFlpftn--------------------- 248
CCE42929     167 --------rnYHDRVCDELKKLSQDLAYIVMQYNNATVNLSTTVVNCIDCFKEFnnnik--------------------- 217
XP_001525183 166 --------kdEGYSVVDELRQLSQDLAYIMHQLNNSSVNLSTAVMNLIDCFKSFstsyravptisaatkekrtrtvgdae 237
EMG48102     144 -------eqtWEDRIRENLKQLYQDLAYIMNQYNNSTINLSTAVIDSIDCLKKF-------------------------- 190
EER32686     149 ---------nLEDLICDNLKQLSQDLSYVVNQFNNSTINLSTAVINTIDCLKKF-------------------------- 193
Q5A341       156 ---------nLEELIRDNLKQLYQDLAYTMSQFYNSSASLSTTVINIIDCLKKF-------------------------- 200 Candida albicans
Q6BY91       163 ---------dIKGTVVDKLHELYEDVLFIMNQYNNSSINLSTTVINTIDCFKKF-------------------------- 207 Debaryomyces ha...
EEQ38717     132 --------anAEEIIADRLHSLWQDISYISNQYVTSVDNLSSSVVNIMDRFKEFrksvkni------------------- 184
XP_001383587 199 ----VSfidtin--------npssldWNFTTFNNSNVRRIMKIYLNFYDNLLRDEVYIKLKLLLVKNFNDFTQTLNSRSS 266
CCK69361     212 ----------------------vvvvPNISSENSSNLRNISKIVFHFLDNLLVSDGFSNSRSILLKRYVQFLKKLNIDPM 269
XP_011273138 249 ----------------------vsnqFNITTENNEQLRNIIKIILQLYDNYLRFEVYINSKNLLIKSFIEFLSRLQFKFP 306
CCE42929     218 ----------------------ekqeSDISTYNNLNLRMIVKYYLHFYDNLLKDDVYIKLKLLLVKHFNDFALHFSDNLN 275
XP_001525183 238 teieTEtisknenknknenenenefqTEVMAYNNLDLRKIIKIYLQYHDDLLQNEVYIKLKLLLMKHFNDFASKFDDEAK 317
EMG48102     191 ----Tqdnvne---------dngeggFSFDTYNSSSLRKIFKIYLHFYDNLLNSQVYIKLKLLLVKNFNDFIMVLNPTEL 257
EER32686     194 ----IAfiekaky------hefsnteFCFTAYNSSSVRKILKIYLHMYDNLLRDDVYIKLKLLLVKNFNEFASVLNHTGL 263
Q5A341       201 ----NVfvekati-------akpneqYIFTSYNSSSLRKILKIYLELYDNLLTDQVYIKLKLLLVKNFNDFAMLLNSQEM 269 Candida albicans
Q6BY91       208 ----VSfaesfg---------sdsesWDITTFNNGDMRRIMKIYLHFYDNLLASDVYIKLKLLLVKNFNDFATTLNSRDK 274 Debaryomyces ha...
EEQ38717     185 --------------------daldgqWCFTSYNNDDVRKLLRTYLHYYDNLLKDDAYIRLKLLLCKAFNDFRLTLKSSSR 244
XP_001383587 267 SV----APATITKPQNFAVGNNKg-lSLPNEDVLERIIEKISST-AI-SMKEQNGSFIAPITRGLSKDLNILCLYFGYPD 339
CCK69361     270 AEre-pGSNTLPYLMNFCIDENH---TLPNTSRLTKLMEEILKTdSS-IISDQTGAFIAPIRRGLCQRASVLSIVFGIPN 344
XP_011273138 307 FN----LFETIPFMKNFAITDEI---ELPNKFKIQQIMETISQSsSN-IISDQEGSFIAPIMRGLTPKTSILAIMFGFPD 378
CCE42929     276 DL------NVMVKPRNFSVGADSv-rDFPNEKVIVRIMDRIAQT-SI-SMQEQNGSFIAPIMRGVSTRLSILCLYFGYPD 346
XP_001525183 318 SS------TVLIKPRYYAVGSGDh-gPFPGEDSVATIMDRIAQV-NL-ASKDQNGSFIAPVLRGVTSKLRILCLYFGLPD 388
EMG48102     258 TN-----NMEMIKPKNFAIGSNEnqySLPNEDVLMRIIDKISHNhNInSSKDQNGSFIAPITRGISSNLNILCLYFGYPD 332
EER32686     264 DSqfnaNPGEMIKPKNYAIGTNRs-sSLPNEEVLIKIMDRISQS-SL-STKEQNGAFIAPITRGISKDLNILCLYFGYPD 340
Q5A341       270 NQ----ISEEMIKPKNYPIGSSKg-kSLPNEEILVRIMEKVSHS-NL-SMKEQNGSFIAPITRGISNNLNILCLYFGYPE 342 Candida albicans
Q6BY91       275 PAn--kPMQNMVKPQNYAIGIDPd-kSLPNEDLIEKIMKKIAST-SI-SVKEQNGSFIAPIARGISNDLNILCLYFGYPN 349 Debaryomyces ha...
EEQ38717     245 VAv---APDSIQKPRNFAVGVNGg-qELPNQREISRIISKIANS-PM-GLKEQNGSFIAPIARGIDRDMNVLCLYFGYPS 318
XP_001383587 340 PTDYHYKLTQTLHELYDDIHVVVIKNQIELASSGAKAE----------------------------ASPITK-------- 383
CCK69361     345 LQQEHYEMIKVLYSMYPDVHLYLTKDSIKPCAKVQS------------------------------PLNSSKfqegihgd 394
XP_011273138 379 PQQDHYEIINALFQSFPDVHFFLKKDYIKPCGIT--------------------------------PKPSS--------- 417
CCE42929     347 PQDMHYKLTQSIHDLYEDIHVMVMRNHIELASTSVSNP----------------------------PQLPTQ-------- 390
XP_001525183 389 PQENHQKVISGISELYDDIHVVIAKNRIELASASVETSiklnnvppvqkiqhhqhsqkgydqhlshSHKQQQ-------- 460
EMG48102     333 PQEYHYNLIQGLRELYDDIHIILTKNQIELAASNTTTD----------------------------NQQHQQ-------- 376
EER32686     341 PKEYHYNLVQGLQGLYEEIHIILMKDQIELASSKEEAI----------------------------TIPPA--------- 383
Q5A341       343 PTEYHHSLTQSLRELYDDVHVVLAKNQIELASATRVDA----------------------------ASTFNK-------- 386 Candida albicans
Q6BY91       350 PTDLHSKLIQSLHGLYDDIHVVVMKNQIELASIMAESA----------------------------SIPFPN-------- 393 Debaryomyces ha...
EEQ38717     319 FTEDNQRIISSITDLFDDVHVMVAKNQIELASSTSAPL----------------------------AGNV---------- 360
XP_001383587 384 LTSFESYHNpnnvgssaapisanQKFKLPFRIPTDAQRPPMSLSLSVENSSRTSGTVGGYIYPIIDIKkQPHLESYASSK 463
CCK69361     395 QLSQTALNDsf-----------gAGFSPPYRIAENPLSPPISMSISTMDSSQMTGTLGGYVFPQI-DK-TSKFSAFSGAS 461
XP_011273138 418 -----------------------SKFKPPFKTLSNKKKPEISLSISSENSIKTTGTLGGFIEPIFHSNtDKSLLKYKGSK 474
CCE42929     391 HKPIVSNAL--------------HKFKLPFRIPTDPLEPPISMSISTENSNRVSGTLGGYIYPKIDLKkQPQLKSYASSK 456
XP_001525183 461 HHHQQQQQQqqqg-------fpvQKFKLPFRVPVDPLQPPMSMSMSTENSLKTSGTVGGYIYPKIDIKkQPNLKSYAASK 533
EMG48102     377 QHQ--------------------QKFKLPFRIPTDNQQIPISMSISIENAVRTSGTMGGYIYPIIDLTkQPHLKSYANSK 436
EER32686     384 -----------------------QKFKLPFRVPTEGEQIPMSMSLSIEKATRTSGTVGGYIHPIIDLEkQPHLKSYANSK 440
Q5A341       387 PAAFNDGFPplqa-------qstQKFKLPFRVPTDIHHVPMSMSISIENATRTSGTMGGYIYPIIDLQkQPHLKSYANSK 459 Candida albicans
Q6BY91       394 YNASESVLPstqv------envvRKFKLPFRNPTDSSRPPISLSLSVENASRLSGTMGGYIYPQIDLEkQPHLESYTNSK 467 Debaryomyces ha...
EEQ38717     361 -----------------------QKFKLPFRNPADPMRPPMSLSLSVETSSRISGTMGGFIYPKIDVSsQPQLTSYANSK 417
XP_001383587 464 FAITCGHVCLDTTNTatteYPHVSAPSSVLISLYKQAVAQQYQKVAchad--eamFADSK-IAYGAVLKQLEEifplkrv 540
CCK69361     462 FAITSAHVLLTESQD----YQDVSVPSSVLQKAYLATILKESKKYP---------ENSQErMAFVKEAQKIKE------- 521
XP_011273138 475 FGITCAHVLLNESQD----YPNVNVPSSVLVHAYMSALRDERDKYP---------ENCMEyVSYNEELKKSEN------- 534
CCE42929     457 FAISCGHVCLD-PQDas-hYCNIASPSASLISLYKSALTAQYQRQGg-------qFNESH-IAYGTILNELEEmfplkki 526
XP_001525183 534 FALSCGHVCLD-PHSps-tYPNIAVPSAALIGMYKQALLAQYERVKg-------sMKDTE-VAYKAVLGELEEmfpsknv 603
EMG48102     437 FAISCGHVCLD-SMNpe-nYPNVASPSSVLISLYKQALTEQYHKCLky------gKDDSKvVAYRSILNQLEEmfplkki 508
EER32686     441 FAVSCGHVCLD-SEDpe-nYPNVSSPSSVLISLYKDALTQQYHKSLhn------nAKDSK-AAFGAMLQQLESmfplk-- 509
Q5A341       460 FAISCGHVCLD-SDNpe-nYPNVSSPSSVLISLYKQALTEQYHKSLnrnnstagvPSETR-VAFGAVLQQLEEmfplkqi 536 Candida albicans
Q6BY91       468 FAISCGHVCLD-NNDedvnYPHVSAPLAVLISLYKKALWTQYQKFSqqgn--nvsTMEER-IAYGSVLKNLDKvfplkkv 543 Debaryomyces ha...
EEQ38717     418 FALSCGHVCLN-KSEdvveYPHVSSPSSVLIGLYKKALSAEYQKLDdieg--dnsVMDSK-LAYASVLKQLDEifplkev 493
XP_001383587 541 kvt----dpktkqekyEVRNLPKNRFGQIIWGERTLINakkdtedkee----sanananaeKRLSDLAIIKVNKNLVCDq 612
CCK69361     522 ----------------QLKWHKENKFGQIVWGERSMVN-----------------------QKLSDISIIKVNPTYKCE- 561
XP_011273138 535 ---------------------FSMDLGQVVWGERVLMPs---------------------sKKISDLSIIKCNSGLKCE- 571
CCE42929     527 kv-----qeknspehyEMRNLPQVRFGQIIWGERTLINlsespne----------isglveRKLSDLAIIKVNKHLKCSy 591
XP_001525183 604 kv-----nmdniqereLGRNLPRHKFGQIIWGERTLIEvlqtpna----------vsglteRKLSDLAIIKVNKHMKCSa 668
EMG48102     509 ks-----sqnekeqvvVMKNLPKHRFGQIIWGERTLLQinqstttpt-----kneisgvveKKLSDLAIIKVNKNLKCQy 578
EER32686     510 -----------kisqdEVRNLPKVRFGQIIWGERTLLTigendein--------qvsgvveKKLSDLAIIKLNKNLKCEc 570
Q5A341       537 kksstrnnnsaykddyEVRNLPKYRFGQIIWGERTLIKlngdtngnssnnhqinemsgiveKKLSDLAIIKVNKKLKCEh 616 Candida albicans
Q6BY91       544 kv-----pysskreghEIRNLPEHRFGQIIWGERTLINlkgsdk-----------asqdveNKLSDLAIIKVNKNLKCDq 607 Debaryomyces ha...
EEQ38717     494 tvt----dsktkkkrtEVRNLPRTRFGQIIWGERTLIQakntkt-----------gkeisdKRLSDLAIIKVNKLLQCDq 558
XP_001383587 613 NFLGDDIQFNeFDPALMFDNLYVR-KV--INLTRyspkqldlnidevds---slssntaevaknysGLSVFKYGSTTKFT 686
CCK69361     562 NHIGNNAKFI-SDPTLRFQNNYVKkKI--MKIKA--------------------------------GLKVFKIGASSNYT 606
XP_011273138 572 NILGDDLDY--YNPSLKFKNLQIKkKIktIDFNK--------------------------------HSKIFKMGASTKYT 617
CCE42929     592 NYLGDDVQFNeFDPALIMDNLYVR-KV--LNLKRfvpktihenvnevdss-vstsslsqdedqcynGIPVFKYGSTTKYT 667
XP_001525183 669 NYLGDDVLFNeYDPSLIFENLYVR-KV--LNLKRyepkpineavkdid-----sqvssfeetenlhGLEVFKYGSTTKYT 740
EMG48102     579 NYLGDDVLFTeYDPGLIFDNLYIR-KV--LSLKRyipkpintniedidsnissssssssssdgtyyGIPVFKYGSTTKYT 655
EER32686     571 NYLGDDVPFNeYDPALMFDNLYVK-KV--LDLKRyapkvvhtdihdvds---disnydstinnnyyGLEAFKMGATTKYT 644
Q5A341       617 NYLGDDVQFNeYDPSLMFDNLYVR-KV--INLKRyvpkvintaiedvd-----sdvsnnseiqtyfGIPVFKYGSTTKYT 688 Candida albicans
Q6BY91       608 NFLGDDIAFNeYDPALMFDNLYVR-KV--INLEReskelninevd-----------svasansnysGLSIFKYGSTTKFT 673 Debaryomyces ha...
EEQ38717     559 NYLGDDIAFNeYDPALFFDNLYVR-KV--INLNRytkeidmdninevds--vdsvitesedsystnGLPVFKYGSTTKFT 633
XP_001383587 687 KGTLNGIKLVYWLDGAIHSSEFIVNSl------eNNSAFAAGGDSGSWILTKLEDieddsyS-KGLGVLGMLHSYDGEFK 759
CCK69361     607 SGQVNGTRLVYWADGKLQSSEFVVAS--------PSPLFAAAGDSGSWILAKSED------Q-LGLGVVGMLHSYDGANQ 671
XP_011273138 618 QGEINGIKLVYWLDGSLQTSEFVVNSensnsnsnNSPIFANSGDSGSLILNNLYG------E-IGLGVIGMLHSFDGELK 690
CCE42929     668 CGNLNGIKLVYWLDGAMHSSEFIVNSi------eHNSAFAGGGDSGSWVLSKLQDlda---taNGLGVLGMLHSYDGEYK 738
XP_001525183 741 RGNLNGIKLVYWLDGEMHSLEFIVNSs------dMTSVFASGGDSGSWIMSKLQDinp---neQGLGVLGMLHSYDGEFK 811
EMG48102     656 KGYMNGIKLVYWLDGAIHSSEFIVNSi------dNNSTFASGGDSGSWILTKLEDinnnggDqKGLGVLGMLHSYDGEFK 729
EER32686     645 RGCLNGIKIVYWMDGQINSSEFVVSS---------DTTFASGGDSGSWLLTKLEDg-------SGLGVLGMLHSYDGQVK 708
Q5A341       689 KGHLNGIKLVYWLDGAIHSSEFIVNSi------eANSSFASGGDSGSWILTKLDDied---nsKGLGVLGMLHSYDGEFK 759 Candida albicans
Q6BY91       674 RGNLNGIKLVYWLDGAIHSSEFVINSv------eSNTAFAAGGDSGSWILTKLEDctsesnS-KGLGVLGMLHSYDGEHK 746 Debaryomyces ha...
EEQ38717     634 KGNLNGIKLVYWLDGAIHSSEFVVNSd------dSTTYFAAGGDSGSWILTKLEDvqgsseR-KGLGVVGMLHSYDGEFR 706
XP_001383587 760 QFGLFTPICEILQRLEEVTSIRWGV 784
CCK69361     672 QFGLFTPIDDILERLHDVTGVHWDI 696
XP_011273138 691 QFGLFTPVDDILDRLNQVTGIEWDf 715
CCE42929     739 QFGLFTPMCEILNRLEEVTNIKWGV 763
XP_001525183 812 QFGLFTPMCEILSRLKEVTNIEWGI 836
EMG48102     730 QFGLFSPMTEILNRLEEVTNIKWGV 754
EER32686     709 QFGLFTPMSEILDRLETVTGIKWSV 733
Q5A341       760 QFGLFTPMTEILSRLEEVTNIKWGV 784 Candida albicans
Q6BY91       747 QFGLFTPMCEILERLETVTNIKWGV 771 Debaryomyces hansenii
EEQ38717     707 QFGLFTPMTEILERLEDVTKIKWGV 731
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