Conserved Protein Domain Family
Inhibitor_I29

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pfam08246: Inhibitor_I29 (this model, PSSM-Id:369782 is obsolete and has been replaced by 462410)
Cathepsin propeptide inhibitor domain (I29)
This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide. There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin. This family is classified as I29 by MEROPS.
Statistics
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PSSM-Id: 369782
Aligned: 59 rows
Threshold Bit Score: 41.8617
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AAAA:OsI_00905  49 FSRWMAQYGKAYs-WPIEHEKRYQIWKDNSNFIGSFRseteissgvgAFAPQTvtdsFV-GMNRFGDLTPGEF 119 long-grained rice
Q4DC63              55 FDRFLQEYGKKY--DAREYVRRRALFEQTLARVRTHN----------EAGNHLy---VM-GINHMSDWTPEEL 111 Trypanosoma cruzi
EGR34360            32 FDQYISDYSKNYakGTREYDQRKIIFESKLQEILSHN----------QNTSHTy---KR-GINAFTDMSHQEF 90  Ichthyophthirius...
Q17IZ6              31 FDTFLGAYQKKYk-AKYRMDRRKRAFKKNMQEIEEHNan-------yEQGKSTf---QM-GVNELADMDKSSY 91  yellow fever mos...
Q9VNK6              30 WDQYKAKYNKQY--RNRDKYHR-ALYEQRVLAVESHNql-------yLQGKVAf---KM-GLNKFSD-TDQRI 87  fruit fly
Q9VKY4              36 FEKFKNNNNRKYl-RTYDEMRSYKAFEENFKVIEEHNqn-------yKEGQTSf---RL-KPNIFADMSTDGY 96  fruit fly
XP_695425           41 WNLWKKKHEISYd-EESEDVHRKTIWETNMQKIWKNNnd-------fSFGLSMf---KM-AMNKYGDLTSVEY 101 zebrafish
Q24HI2              36 HDDYVLSLARLYrpHLNVEHLEFQHFKESVRRVREHN----------KKVNATy---TLsIDSPFAFMSDEQF 95  Tetrahymena ther...
EDO08563           120 FNDFNRDFKRHDn-SISEKIERFATFYRNVTRIREFN----------MNVHKTy---TM-KINQFADMTPEQF 177 Babesia bovis
Q75PZ5              54 yRLYKRKYNKRDe-EINLEHRRFMTYLKNVKEIEKHNer-------yERNEETy---EL-AINHLADMLPEEF 114 Brugia malayi
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