Conserved Protein Domain Family
FAST_2

?
pfam08368: FAST_2 (this model, PSSM-Id:369835 is obsolete and has been replaced by 400599)
FAST kinase-like protein, subdomain 2
This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.
Statistics
?
PSSM-Id: 369835
View PSSM: pfam08368
Aligned: 90 rows
Threshold Bit Score: 65.6587
Threshold Setting Gi: 0
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
ETE62933      525 LMELNRAVCLECPELQIPWFHKRFCEQLKEKNTDLS------GLLQQQIYILLGEILGRSHYARCSVLTSYFYRI----- 593 king cobra
XP_003409852  358 LSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDrar-skYSHKDIVAEGLRQLLGEEK-YRQDLTVPPGYCT----- 430 African savann...
EEC14005      439 LKFLDSALTLECKQYYGPFLPRDYSAKSVKRDGRL-------LRLMCSLQEDMEQVVGVEN-FSFSVVQPR---Lplldm 507 black-legged tick
XP_005460108  548 LFTLDGVVALELPQWTGPRLSSELRDEVTEMLWKFAqsdvcqKPEVQEAESALKDLLGGEEFVCKRMILPHTRSI----- 622 Nile tilapia
38_pfamImport   1 -FTLDGTVGIELPGWTGPRLSQAFREEVTKQLWDFAkfdicqKPEVIEAEEVLQGLLGGEAFVRKGMILPHMRSI----- 74 
XP_698448     525 LFTLDGTVGLELPESTIPRLSLAVREEVTKQLWDFAqseicqKLEVLEAESMLQKLLGGEMFVRKHMILPHLRSI----- 599 zebrafish
XP_002936403  561 LFTLDGSVEIECPEYTGNHLSMELRQEVTEMLQSFSrqdiciKPEVLEAATLIESMLGGPQYVKNHMILPHTRSN----- 635 tropical clawe...
XP_005994284  207 LSLLDSAVELEYEDYSGPRLEERYKVMMFDHALTADevn-rkYSYKGLVAEALRQLVGEQC-YKQDEVLPPGYYT----- 279 coelacanth
CAF90269      414 LSLLDAAVELEFREYSGPRLQDAHKVLMFDHALTADevn-rkYSYKGLVAEALRQLLGEHK-YRQDQVLPPGYYT----- 486 spotted green ...
XP_008122664  289 LSLLDTAMALEVPGYDGPRLDPRFHVQMFDGALTADdan-rkYSFKGLVGEGLQRLVGRDG-FQQDVVVPPGYGV----- 361 green anole
ETE62933      594 ---DFEFMIDK-NKKPV 606 king cobra
XP_003409852  431 ---DFLLCVSS-NGAVL 443 African savanna elephant
EEC14005      508 yiiDYVVQLNK-QGKPV 523 black-legged tick
XP_005460108  623 ---DLEVHLNS-TGQPV 635 Nile tilapia
38_pfamImport  75 ---DLEVHLDT-NEQPL 87 
XP_698448     600 ---DLEVHLDQ-NDQPV 612 zebrafish
XP_002936403  636 ---DLEVHLDV-GEKPI 648 tropical clawed frog
XP_005994284  280 ---DFLLWINN-SGSVv 292 coelacanth
CAF90269      487 ---DFLLWMNG-PGQVL 499 spotted green pufferfish
XP_008122664  362 ---DFLLHVSSlSGEVL 375 green anole
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap