pfam10238: Eapp_C (this model, PSSM-Id:370909 is obsolete and has been replaced by 463015)
E2F-associated phosphoprotein
This entry represents the conserved C-terminal portion of an E2F binding protein. E2F transcription factors play an essential role in cell proliferation and apoptosis and their activity is frequently deregulated in human cancers. E2F activity is regulated by a variety of mechanisms, frequently mediated by proteins binding to individual members or a subgroup of the family. EAPP interacts with a subset of E2F factors and influences E2F-dependent promoter activity. EAPP is present throughout the cell cycle but disappears during mitosis.
Jiyao W et al.(2023). "The conserved domain database in 2023.",