Conserved Protein Domain Family
TMEM65
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pfam10507: TMEM65 (this model, PSSM-Id:371101 is obsolete and has been replaced by 463123)
Transmembrane protein 65
MEM65 is an intercalated disc protein that interacts with with connexin 43 (Cx43) and is required for correct localization of Cx43 to the intercalated disc. It is essential for cardiac function in zebrafish.
Links
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Statistics
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PSSM-Id: 371101
Aligned: 61 rows
Threshold Bit Score: 118.728
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EED90065      29 QSIPFVGFGIMDNSILLLAGEAIDTTLGVTLGISTMCAAAIGNIISDVVGVAFGTVIEDAIARwsgrierlsngkVKLpP 108 Thalassiosira p...
Q38AF3       147 AGLPFVGFGFLDNAMMILAGDAIDNSFGLYFNCSVLTCAAMGNIFSGVLGMQLHGVIEKAVQR------------FNF-R 213 Trypanosoma brucei
CAM44473     166 AALPFVGFGFLDNSTMILAGDMIDGSLGFYLNCSVLASAAMGNVCSGVLGMQVHGLIDNTVQK------------LNL-N 232 Leishmania braz...
CAM65792     669 AAPPFLAFGMLDNSTLVLAGGAIDNALSGSLGLSQMAAASLGGVVSGVAGIQVHGLAERYTRA----------------A 732 Leishmania infa...
Q57ZW2       304 ASVPFMAFGILDNSIFVTAGDAIDRRCAEAFGLTSMTAAALGGVVSGVAGVQMHGVAERFTQR------------VRLaR 371 Trypanosoma brucei
Q4CY30       293 SAVPFMAFGMLDNTIFITAGDAIDKRFAEAFGMSTMAAAALGGVVSGTAGIQMHGLAERMAQR------------SRLaR 360 Trypanosoma cruzi
Q84X76       164 AAIPFVAFGFLDNAIMLVAGEEIDHMFGLRLGLSTLASAGLGNAVADVIGVGAAKYIEQAVRW------------LPFvK 231 Chlamydomonas r...
EGB10611       7 AAVPCFTFGFLDNAIMLVCGEAIEGSLGVKFGLSAMACAAMGNVVADTTGQVSGGTVDTMLRP--------------VlP 72  Aureococcus ano...
XP_009534790 101 SAIPFVGFGLVDNLILLVAGDAIETHFHSSYAMSMLCAAALGNTVADVVGLSLGGVVESMARR------------LGI-P 167 Phytophthora sojae
GAX95418      96 SAIPFIGFGFVDNIIMLAAGDMIEDHFHETFHISMLCAAALGNTVADVVGLSLGGIIESFVRR------------IGI-P 162 Pythium insidiosum

EED90065     109 LPKLSHEQRNLRSVRLASQLGCAIGLTVGCIIGMFPLLFF 148 Thalassiosira pseudonana CCMP1335
Q38AF3       214 VPTLTENQMKGKRVFFAGHIGGTVGIMTGLLLGMIPLLLL 253 Trypanosoma brucei
CAM44473     233 TPVLSEEQLKDRRVFLAGHLGGTLGIMLGLILGMLPLLFL 272 Leishmania braziliensis MHOM/BR/75/M2904
CAM65792     733 PPRLTMEQQRSDAYSRATQAGNTLGMVFGLILGMIPLLFM 772 Leishmania infantum JPCM5
Q57ZW2       372 VPVLTAAQQKSKARGSATRVGNTAGMLVGLLLGMIPLLFV 411 Trypanosoma brucei
Q4CY30       361 PPTLTPSQSASASNGSATRVGSTLGMILGLLFGMTPLLLL 400 Trypanosoma cruzi
Q84X76       232 EPKLNKYQNAMPATQRAKLAGAMLGVFCGCMLGLTPLFLs 271 Chlamydomonas reinhardtii
EGB10611      73 APRLSEAQRASRAASLTHAVGGAVGIFVGCVFGSFPLLFY 112 Aureococcus anophagefferens
XP_009534790 168 DPMLSKAQANMSITHWCNFFASAGGITIGCLIGMIPLLWM 207 Phytophthora sojae
GAX95418     163 DPCLSKAQARMAITHWANFLASAGGITLGCILGMFPLLFM 202 Pythium insidiosum
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